Korean J Med.
2000 Sep;59(3):335-338.
Hyponatremia in schizophrenia after water intoxification: a potential cause of rhabdomyolysis
- Affiliations
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- 1Department of Internal Medicine, Hanyang University, Kuri, Korea.
Abstract
- Electrolyte disturbance that can produce rhabdomyolysis include hyperosmolar states, especially with marked hyperglycemia, or hypernatremia, severe hypokalemia, and hypophosphatemia, which is commonly seen in alcholics. Hyponatremia, however, is often an unrecognized initiating factor of rhabdomyoplysis. A 56-year-old man, treated for schizophrenia, developed severe hypotonic hyponatremia (Na:117meq/L) with mental change after several days of compulsive water drinking. Rhabdomyolysis quickly followed with high serum creatine phosphokinease level and myoglobulinuria. Massive hydration and urine alkalization started. Renal failure or compartment syndrome did not complicated. Hyponatremia may cause reduced rate of entry of sodium ions ,and reduces the exchange for calcium ion we thought elevated calcium concentration activated neutral proteases and lipases that serve to destroy the cell.
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