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Comparison of the Efficacy and Safety of Insulin Detemir Administered Once Daily According to Two Titration Algorithms (3-0-3 and 2-4-6-8) in Patients with Type 2 Diabetes Mellitus

Yu HM, Park KS, Hong JH, Park KY, Lee JM, Ku BJ, Kim YJ, Oh TK

BACKGROUND: This study was conducted to compare glycaemic control with insulin detemir administered according to two titration algorithms (3-0-3 and 2-4-6-8) after 20 weeks of treatment in subjects with type...
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Dietary nobiletin suppresses TGF-β1-Src-caveolin-1 dependent signaling involved with high glucose-induced renal mesangial matrix accumulation

Kim DY, Kang YH, Kang MK

PURPOSE: Diabetic nephropathy is one of the most important diabetic complications prompted by chronic hyperglycemia, characterized by glomerulosclerosis, tubular fibrosis, and it eventually causes kidney failure. Nobiletin is a polymethoxyflavone...
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Serial Magnetic Resonance Imaging Findings in Hyperglycemia-Related Osmotic Demyelination Syndrome: A Case Report

Kim JH, Park NH, Park JY, Kim SJ

We report a rare case of hyperglycemia-related osmotic demyelination syndrome (ODS) with focus on the imaging findings. A 61-year-old man with diabetes was admitted for general weakness and severe thirst....
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Effect of High β-glucan Barley on Postprandial Blood Glucose and Insulin Levels in Type 2 Diabetic Patients

Fuse Y, Higa M, Miyashita , Fujitani A, Yamashita , Ichijo T, Aoe S, Hirose T

The aim of our study was to investigate whether high β-glucan-containing barley (7.2 g per 100 g) improves postprandial plasma glucose levels and suppresses postprandial insulin levels during a meal...
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Cross-Sectional Association of Metabolic Syndrome and Its Components with Serum Testosterone Levels in a Korean-Screened Population

Kim M, Kyung YS, Ahn TY

PURPOSE: We evaluated the associations of metabolic syndrome (MetS) and its components with testosterone levels in the Korean population. MATERIALS AND METHODS: This cross-sectional study was performed among 6,967 adult (age≥20...
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Cognitive dysfunctions in individuals with diabetes mellitus

Kim HG

Some patients with type 1 and type 2 diabetes mellitus (DM) present with cognitive dysfunctions. The pathophysiology underlying this complication is not well understood. Type 1 DM has been associated...
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The Role of Anti-Obesity Medication in Prevention of Diabetes and Its Complications

Oh TJ

Diabetes is prevalent in obese population, and obesity management is the first step in preventing diabetes. Traditionally, lifestyle modification including reduced-calorie diet, physical activity, and behavior intervention is the core...
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Association between components of metabolic syndrome and periodontitis in Korean adults aged 35–79 years

Kim JS, Kim SY, Byon MJ, Lee JH, Jeong SH, Kim JB

OBJECTIVES: The purpose of this study was to investigate the association between the components of metabolic syndrome (MetS) (waist circumference, hyperglycemia, hypertriglyceridemia, low levels of high-density lipoprotein cholesterol, and hypertension)...
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Comprehensive Management in Patients with Type 2 Diabetes Mellitus

Kim SK

Management of patients with diabetes mellitus should not be restricted to the treatment of hyperglycemia and diabetic complications. An integrated comprehensive approach is needed for successful management, which should include...
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Risk Factors Management in Diabetic Patients

Kim SY

Diabetes mellitus is associated with a high frequency of complications related to cardiovascular disease as well as microvascular complications such as nephropathy, retinopathy, and neuropathy. Prevention of these vascular complications...
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Higher glucagon-to-insulin ratio is associated with elevated glycated hemoglobin levels in type 2 diabetes patients

Lee M, Kim M, Park JS, Lee S, You J, Ahn CW, Kim KR, Kang S

BACKGROUND/AIMS: The importance of α-cell dysfunction in the pathogenesis of type 2 diabetes has re-emerged recently. However, data on whether relative glucagon excess is present in clinical settings are scarce....
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Enrichment of Short-Chain Ceramides and Free Fatty Acids in the Skin Epidermis, Liver, and Kidneys of db/db Mice, a Type 2 Diabetes Mellitus Model

Kim M, Jeong H, Lee B, Cho Y, Yoon WK, Cho A, Kwon G, Nam KT, Ha H, Lim KM

Patients with diabetes mellitus (DM) often suffer from diverse skin disorders, which might be attributable to skin barrier dysfunction. To explore the role of lipid alterations in the epidermis in...
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Downregulation of IL-18 Expression in the Gut by Metformin-induced Gut Microbiota Modulation

Lee H, Kim J, An J, Lee S, Choi D, Kong H, Song Y, Park IH, Lee CK, Kim K

IL-18 is a crucial pro-inflammatory cytokine that mediates chronic intestinal inflammation. Metformin, an anti-diabetic drug, was reported to have ameliorative effects on inflammatory bowel disease. Recently, the mechanism of action...
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2019 Clinical Practice Guidelines for Type 2 Diabetes Mellitus in Korea

Kim MK, Ko SH, Kim BY, Kang ES, Noh J, Kim SK, Park SO, Hur KY, Chon S, Moon MK, Kim NH, Kim SY, Rhee SY, Lee KW, Kim JH, Rhee EJ, Chun S, Yu SH, Kim DJ, Kwon HS, Park KS, Committee of Clinical Practice Guidelines, Korean Diabetes Association

The Committee of Clinical Practice Guidelines of the Korean Diabetes Association revised and updated the 6th Clinical Practice Guidelines in 2019. Targets of glycemic, blood pressure, and lipid control in...
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Continuous Glucose Monitoring Sensors for Diabetes Management: A Review of Technologies and Applications

Cappon G, Vettoretti M, Sparacino , Facchinetti A

By providing blood glucose (BG) concentration measurements in an almost continuous-time fashion for several consecutive days, wearable minimally-invasive continuous glucose monitoring (CGM) sensors are revolutionizing diabetes management, and are becoming...
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Effect of Hyperglycemia on Myocardial Perfusion in Diabetic Porcine Models and Humans

Park JJ, Kim SH, Kim MA, Chae IH, Choi DJ, Yoon CH

BACKGROUND: Diabetes mellitus (DM) causes macro- and microvasculopathy, but data on cardiac microvascular changes in large animals are scarce. We sought to determine the effect of DM on macro- and...
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Acarbose Add-on Therapy in Patients with Type 2 Diabetes Mellitus with Metformin and Sitagliptin Failure: A Multicenter, Randomized, Double-Blind, Placebo-Controlled Study

Yang HK, Lee SH, Shin J, Choi YH, Ahn YB, Lee BW, Rhee EJ, Min KW, Yoon KH

BACKGROUND: We evaluated the efficacy and safety of acarbose add-on therapy in Korean patients with type 2 diabetes mellitus (T2DM) who are inadequately controlled with metformin and sitagliptin. METHODS: A total...
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Time-Dependent Changes of Urethral Function in Diabetes Mellitus: A Review

Cao N, Gu B, Gotoh D, Yoshimura

This article reviewed the current knowledge on time-course manifestation of diabetic urethral dysfunction (DUD), and explored an early intervention target to prevent the contribution of DUD to the progression of...
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Multi-Parametric Quantitative MRI for Measuring Myelin Loss in Hyperglycemia-Induced Hemichorea

Youn SW, Kwon OD, Hwang MJ

Hyperglycemia-induced hemichorea (HGHC) is a rare but characteristic hyperkinetic movement disorder involving limbs on one side of the body. In a 75-year-old woman with a left-sided HGHC, conventional brain MR...
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Prevention of Major Adverse Cardiovascular and Renal Outcomes with Sodium-Glucose Cotransporter 2 Inhibitors

Hong JH

Management of hyperglycemia limits progression of microvascular complications in type 2 diabetes mellitus (T2DM). According to large-scale randomized control studies to demonstrate the cardiovascular safety of sodium-glucose cotransporter 2 (SGLT2)...
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