Korean J Psychopharmacol.
2006 Jul;17(4):396-401.
A Case of Hyponatremia Complicated by Rhabdomyolysis during Clozapine and Nemonapride Treatment
- Affiliations
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- 1Department of Psychiatry, College of Medicine, Dongguk University, Gyungju, Korea. ciw@duih.org
- 2Department of Neuropsychiatry, Dongguk University, Ilsan Hospital, Goyang, Korea.
Abstract
- We experienced a case of severe hyponatremia complicated by rhabdomyolysis in a schizophrenic patient who had been treated with clozapine and nemonapride. The exact cause of sudden hyponatremia was uncertain, however, the possibility of chronic polydipsia could not be ruled out. Electrolyte imbalance was corrected by isotonic saline infusion, and plasma sodium concentration returned to normal after 24 hours. However, the patient developed severe rhabdomyolysis with myoglobinuria and acute renal failure. After 18 days of treatment, patient's physical and mental condition stabilized without further complication. Possible contribution of clozapine in increasing the risk of rhabdomyolysis after the correction of hyponatremia was briefly discussed.
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