Korean J Nephrol.  2003 Jan;22(1):102-108.

Association among C-Reactive Protein, Pulse Pressure and Ischemic Heart Disease in Patients with Continuous Ambulatory Peritoneal Dialysis

• Lee JI
• Kwon SK
• Kim SH
• Seo JW
• Chang JW
• Kim SB
• Lee SK
• Park JS

Abstract

BACKGROUND
Atherosclerotic vascular disease is the major cause of morbidity and mortality in dialysis patients. C-reactive protein (CRP) appears to be clinically useful in prediction of coronary heart disease. Elevated pulse pressure has been associated with an increased risk of cardiovascular disease among apparently healthy adults. Therefore, we evaluated the association between a persistent elevation of C-reactive protein level, pulse pressure and the presence of ischemic heart disease in patients with continuous ambulatory peritoneal dialysis (CAPD). METHODS: A total of 71 CAPD patients (42 males, 29 females) who underwent thallium SPECT and followed up more than 6 months were included. We collected the data about age, sex, smoking, diabetes, hypertension, pulse pressure and body mass index. Blood levels of albumin, total cholesterol, fibrinogen, lipoprotein (a) and C-reactive protein were measured. RESULTS: The values of C-reactive protein, pulse pressure, smoking and fibrinogen were significantly higher in thallium SPECT positive group (p<0.05). A 0.01 mg/dL increase in C-reactive protein was associated with a 1.014 increase in the odds of having an elevated risk of coronary artery disease (95% confidence interval 1.008-1.019) and a 1 mmHg increase in pulse pressure was associated with a 1.017 increase in the odds of having an elevated risk of coronary artery disease (95% confidence interval 1.011-1.023). By multivariate logistic regression analysis, C-reactive protein and pulse pressure were independent risk factors for ischemic heart disease. Log CRP level was positively correlated with pulse pressure level (p<0.01). CONCLUSION: The baseline level of CRP and pulse pressure independently predicts the risk of coronary heart disease in CAPD patients. For patients who have a persistent elevation of CRP and pulse pressure without an apparent cause, we recommend a workup for ischemic heart disease.

Keyword

C-reactive protein; Pulse pressure; Coronary heart disease; CAPD

MeSH Terms

Adult
Blood Pressure*
Body Mass Index
C-Reactive Protein*
Cardiovascular Diseases
Cholesterol
Coronary Artery Disease
Coronary Disease
Dialysis
Fibrinogen
Humans
Hypertension
Lipoprotein(a)
Logistic Models
Male
Mortality
Myocardial Ischemia*
Peritoneal Dialysis, Continuous Ambulatory*
Risk Factors
Smoke
Smoking
Thallium
Tomography, Emission-Computed, Single-Photon
Vascular Diseases
C-Reactive Protein
Cholesterol
Fibrinogen
Lipoprotein(a)
Smoke
Thallium