Korean J Nucl Med.  2004 Apr;38(2):115-120.

Introduction To Basic Molecular Biologic Techniques For Molecular Imaging Researches

  • 1Department of Nuclear Medicine and Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea. kang2325@snu.ac.kr


Molecular imaging is a rapidly growing field due to the advances in molecular biology and imaging technologies. With the introduction of imaging reporter genes into the cell, diverse cellular processes can be monitored, quantified and imaged non-invasively in vivo. These processes include the gene expression, protein-protein interactions, signal transduction pathways, and monitoring of cells such as cancer cells, immune cells, and stem cells. In the near future, molecular imaging analysis will allow us to observe the incipience and progression of the disease. These will make us easier to give a diagnosis in the early stage of intractable diseases such as cancer, neuro-degenerative disease, and immunological disorders. Additionally, molecular imaging method will be a valuable tool for the real-time evaluation of cells in molecular biology and the basic biological studies. As newer and more powerful molecular imaging tools become available, it will be necessary to corporate clinicians, molecular biologists and biochemists for the planning, interpretation, and application of these techniques to their fullest potential. In order for such a multidisciplinary team to be effective, it is essential that a common understanding of basic biochemical and molecular biologic techniques is achieved. Basic molecular techniques for molecular imaging methods are presented in this paper.


Cloning; Expression vectors; Gene; Molecular biology; PCR

MeSH Terms

Cloning, Organism
Gene Expression
Genes, Reporter
Molecular Biology
Molecular Imaging*
Polymerase Chain Reaction
Signal Transduction
Stem Cells
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