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Genomic Approach to the Assessment of Adverse Effects of Particulate Matters on Skin Cancer and Other Disorders and Underlying Molecular Mechanisms

Kee NG, Kim HS, Choi H, Kim HJ, Seo YR

Air pollutants are in the spotlight because the human body can easily be exposed to them. Among air pollutants, the particulate matter (PM) represents one of the most serious toxicants...
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Monogenic diabetes mellitus and clinical implications of genetic diagnosis

Kang E, Chung LY, Kim YJ, Oh KE, Rhie YJ

Monogenic diabetes mellitus, which is diabetes caused by a defect in a single gene that is associated with β cell function or insulin action, accounts for 1% to 6% of...
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Transcriptome Analysis Identifies Altered Biological Processes and Novel Markers in Human Immunodeficiency Virus-1 Long-Term Non-Progressors

Lee D, Yoon CH, Choi SY, Kim JE, Cho YK, Choi BS, Park J

Background: The latent reservoir of Human Immunodificiency Virus-1 (HIV-1) has been a major barrier to the complete eradication of HIV-1 and the development of HIV therapy. Longterm non-progressors (LTNPs) are...
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Apoptin gene delivery by a PAMAM dendrimer modified with a nuclear localization signal peptide as a gene carrier for brain cancer therapy

Bae Y, Lee J, Kho C, Choi JS, Han J

In this study, we aimed to synthesize PAMAMG3 derivatives (PAMAMG3-KRRR and PAMAMG3-HKRRR), using KRRR peptides as a nuclear localization signal and introduced histidine residues into the KRRR-grafted PAMAMG3 for delivering...
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Alteration of TGFB1, GDF9, and BMPR2 gene expression in preantral follicles of an estradiol valerate-induced polycystic ovary mouse model can lead to anovulation, polycystic morphology, obesity, and absence of hyperandrogenism

Asghari R, Shokri-Asl V, Rezaei H, Tavallaie M, Khafaei M, Abdolmaleki A, Majdi Seghinsara A

Objective: In humans, polycystic ovary syndrome (PCOS) is an androgen-dependent ovarian disorder. Aberrant gene expression in folliculogenesis can arrest the transition of preantral to antral follicles, leading to PCOS. We...
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Diagnosis of catecholaminergic polymorphic ventricular tachycardia during late adulthood due to a rare genetic variant in RYR2: a case report

 García‑Cano L, Brouzet T, García‑Fernández A, Ibáñez‑Criado J, Monteagudo‑Viana M, Ibáñez‑Criado A, Martínez‑Martínez J

Background Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a severe hereditary channelopathy characterized by the presence of ventricular arrhythmias triggered by adrenergic stimuli, usually diagnosed in the first two decades of life....
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Optimal Ratio of Wnt3a Expression in Human Mesenchymal Stem Cells Promotes Axonal Regeneration in Spinal Cord Injured Rat Model

Yoon HH, Lee HJ, Min J, Kim JH, Park JH, Kim JH, Kim SW, Lee H, Jeon SR

Objective : Through our previous clinical trials, the demonstrated therapeutic effects of MSC in chronic spinal cord injury (SCI) were found to be not sufficient. Therefore, the need to develop...
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Histopathological Analysis of Esophageal Mucosa in Patients with Achalasia

Lee BE, Kim GH, Shin N, Park DY, Song GA

Background/Aims: Achalasia is an esophageal motor disorder that leads to functional esophageal obstruction. Food stasis and bacterial fermentation can predispose an individual to esophageal mucosal inflammation, causing multifocal dysplasia and...
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Altered Gene Expression Profiles in Neural Stem Cells Derived from Duchenne Muscular Dystrophy Patients with Intellectual Disability

Koo J, Park S, Sung SE, Lee J, Kim DS, Lee J, Lee JR, Kim NS, Lee DY

  • KMID: 2519888
  • Exp Neurobiol.
  • 2021 Aug;30(4):263-274.
  • doi: 10.5607/en21008
Intellectual disability (ID) is a neurodevelopmental disorder defined by below-average intelligence (intelligence quotient of
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Analysis of the Genome Sequence of Strain GiC-126 of Gloeostereum incarnatum with Genetic Linkage Map

Jiang WZ, Yao FJ, Fang M, Lu LX, Zhang YM, Wang P, Meng JJ, Lu J, Ma XX, He Q, Shao KS, Khan AA, Wei YH

Gloeostereum incarnatum has edible and medicinal value and was first cultivated and domesticated in China. We sequenced the G. incarnatum monokaryotic strain GiC-126 on an Illumina HiSeq X Ten system...
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The Role of Thyroid Hormone in the Regulation of Cerebellar Development

Ishii S, Amano I, Koibuchi N

The proper organized expression of specific genes in time and space is responsible for the organogenesis of the central nervous system including the cerebellum. The epigenetic regulation of gene expression...
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Prevention with 240 mg Galcanezumab of Episodic Cluster Headache

Mo H, Song MJ, Cho SJ

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Congenital Myasthenic Syndrome Related to CHRNA1 Variant

Ahn JW, Hwang SK, Kim JH, Jung H, Park JS

Congenital myasthenic syndromes are a genetically and clinically heterogeneous group of neuromuscular disorders linked by abnormal signal transmission at the motor endplate caused by various genetic defects. Major clinical symptoms...
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Update on Treatment of Cluster Headache

Sohn JH, Lee MJ, Cho SJ

Cluster headache (CH) is characterized by severe unilateral short-lasting headache attacks, accompanying ipsilateral cranial autonomic symptoms or the sense of restlessness and agitation, or both. CH is a highly disabling...
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Effects of Androgen Receptor Overexpression on Chondrogenic Ability of Rabbit Articular Chondrocytes

Hui L, Shoumei X, Zhoujing Z, Kuang G, Duohong Z, Jiacai H, Yong Z

BACKGROUND: The role of sex hormones and their receptors has drawn much attention in the process of cartilage regeneration. This study aimed to investigate the effect of androgen receptor (AR)...
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Transcriptome Analysis and Expression Profiling of Molecular Responses to Cd Toxicity in Morchella spongiola

Hongyan X, Zhanling X, Hongchen J, Jing G, Qing M, Yuan Z, Xiaofang W

Morchella is a genus of fungi with the ability to concentrate Cd both in the fruit-body and mycelium. However, the molecular mechanisms conferring resistance to Cd stress in Morchella are...
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Morphological and Molecular Phylogenetic Data of the Chinese Medicinal Fungus Cordyceps liangshanensis Reveal Its New Systematic Position in the Family Ophiocordycipitaceae

Wang Y, Dai YD, Yang ZL, Guo R, Wang YB, Yang ZL, Ding L, Yu H

A cordycipitoid fungus infecting Hepialidae sp. in Nepal was supposed to be identical to Cordyceps liangshanensis, originally described from southwestern China, and thus, transferred to the genus Metacordyceps or Papiliomyces...
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Restoration of the adipogenic gene expression by naringenin and naringin in 3T3-L1 adipocytes

Dayarathne LA, Ranaweera SS, Natraj P, Rajan P, Lee YJ, Han CH

Background: Naringenin and its glycoside naringin are well known citrus flavonoids with several therapeutic benefits. Although the anti-adipogenic effects of naringenin and naringin have been reported previously, the detailed mechanism...
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Molecular detection and genetic diversity of bovine papillomavirus in dairy cows in Xinjiang, China

Meng Q, Ning C, Wang L, Ren Y, Li J, Xiao C, Li Y, Li Z, He Z, Cai X, Qiao J

Background: Bovine papillomatosis is a type of proliferative tumor disease of skin and mucosae caused by bovine papillomavirus (BPV). As a transboundary and emerging disease in cattle, it poses a...
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Molecular characterization of Malaysian fowl adenovirus (FAdV) serotype 8b species E and pathogenicity of the virus in specificpathogen-free chicken

Sabarudin NS, Tan SW, Phang YF, Omar AR

Background: Inclusion body hepatitis (IBH) is an economically important viral disease primarily affecting broiler and breeder chickens. All 12 serotypes of fowl adenovirus (FAdV) can cause IBH. Objectives: To characterize FAdV...
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