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Characteristics of Pruritus according to Morphological Phenotype of Psoriasis and Association with Neuropeptides and Interleukin-31

Park SM, Kim GW, Kim HS, Ko HC, Kim MB, Kim BS

BACKGROUND: Pruritus is a common symptom in psoriasis. However, few studies have assessed the characteristics of pruritus according to morphological phenotypes of psoriasis. OBJECTIVE: To investigate the characteristics of pruritus according...
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Short-term Haze Exposure Predisposes Healthy Volunteers to Nasal Inflammation

Xian M, Wang K, Lou H, Wang Y, Zhang L, Wang C

PURPOSE: This study aimed to investigate the impact of short-term haze exposure on nasal inflammation in healthy volunteers. METHODS: Thirty-three healthy university students were assessed for nasal symptoms, nasal patency, upper...
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Ultrastructure of Substance P Immunopositive Axons in the Human Dental Pulp

Moon BH, Ha JH, Han HM, Kim TH, Park SK, Bae YC

There exists very little information on the ultrastructure of substance P immunopositive (+) fibers in the human dental pulp, which may help in understanding the mechanism for substance P associated...
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Comparison of Angiogenic Activities of Three Neuropeptides, Substance P, Secretoneurin, and Neuropeptide Y Using Myocardial Infarction

Lee J, Song M, Kim J, Park Y

BACKGROUND: The interplay between neurogenesis and angiogenesis is crucial during the development mediated by neuro-angiogenic morphogens. In particular, the angiogenic activity of neuropeptides and their role in tissue regeneration have...
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Fabrication of Microchannels and Evaluation of Guided Vascularization in Biomimetic Hydrogels

Lee J, Lee SH, Lee BK, Park SH, Cho YS, Park Y

BACKGROUND: The fabrication of microchannels in hydrogel can facilitate the perfusion of nutrients and oxygen, which leads to guidance cues for vasculogenesis. Microchannel patterning in biomimetic hydrogels is a challenging...
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Allopregnanolone suppresses mechanical allodynia and internalization of neurokinin-1 receptors at the spinal dorsal horn in a rat postoperative pain model

Fujita M, Fukuda T, Sato Y, Takasusuki T, Tanaka M

BACKGROUND: To identify a new strategy for postoperative pain management, we investigated the analgesic effects of allopregnanolone (Allo) in an incisional pain model, and also assessed its effects on the...
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Hepatotoxicity and nephrotoxicity of saponin-enriched extract of Asparagus cochinchinensis in ICR mice

Sung JE, Choi JY, Kim JE, Lee HA, Yun WB, Park JJ, Kim HR, Song BR, Kim DS, Lee CY, Lee HS, Lim Y, Hwang DY

The inhibitory effects of Asparagus cochinchinensis against inflammatory response induced by lipopolysaccharide (LPS), substance P and phthalic anhydride (PA) treatment were recently reported for some cell lines and animal models....
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Intravenous Administration of Substance P Attenuates Mechanical Allodynia Following Nerve Injury by Regulating Neuropathic Pain-Related Factors

Chung E, Yoon TG, Kim S, Kang M, Kim HJ, Son Y

This study aimed to investigate the analgesic effect of substance P (SP) in an animal model of neuropathic pain. An experimental model of neuropathic pain, the chronic constriction injury (CCI)...
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A proposal of injection points of botulinum toxin into temporal region for chronic migraine

Kim YG, Bae JH, Kim ST

Botulinum toxin (BoNT) injections have been used not only in the field of cosmetic surgery such as forehead and eye wrinkle treatment but also in the treatment of chronic migraine,...
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Substance P and Calcitonin Gene-Related Peptide in the Glands of External Auditory Canal Skin

Yoon YJ, Yoon J, Lee EJ, Kim JS

OBJECTIVES: The earwax (cerumen) that covers external auditory canal (EAC) skin contains a mixture of ceruminous and sebaceous gland substances, such as lipids, peptides, and proteins. The components secreted from...
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Stressful Events and Serum Concentration of Substance P in Acne Patients

Rokowska-Waluch A, Pawlaczyk , Cybulski M, Żurawski , Kaczmarek , Michalak M, Mojs E

BACKGROUND: Psychological stress is an important factor of acne pathogenesis. Stress related production of hormones, cytokines and neuropeptides may result in the chronic course and exacerbations of the disease. OBJECTIVE: The...
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Tryptase and Protease-Activated Receptor 2 Expression Levels in Irritable Bowel Syndrome

Liang WJ, Zhang G, Luo HS, Liang LX, Huang D, Zhang FC

BACKGROUND/AIMS: Previous studies have revealed that mast cells (MCs) may activate the protease-activated receptors and release of neuropeptides involved in the pathogenesis of irritable bowel syndrome (IBS). The levels of...
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Substance P Modulates Properties of Normal and Diabetic Dermal Fibroblasts

Jung N, Yu J, Um J, Dubon MJ, Park KS

Dermal fibroblasts play essential roles in wound healing. However, they lose their normal regenerative functions under certain pathologic conditions such as in chronic diabetic wounds. Here, we show that substance...
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Substance P and Thiorphan Synergically Enhance Angiogenesis in Wound Healing

Um J, Yu J, Dubon MJ, Park KS

Impaired angiogenesis is a common pathological characteristic of chronic wounds. Therefore, the regulation of angiogenesis is important for proper tissue repair. It was reported that substance P (SP) accelerates wound...
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Stress and pain response after oligofructose induced-lameness in dairy heifers

Bustamante HA, Rodriguez , Herzberg D, Werner MP

Lameness is one of the most painful conditions that affects dairy cattle. This study was conducted to evaluate clinical signs and plasma concentration of several pain and stress biomarkers after...
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Effects of DA-9701, a Novel Prokinetic Agent, on Phosphorylated Extracellular Signal-Regulated Kinase Expression in the Dorsal Root Ganglion and Spinal Cord Induced by Colorectal Distension in Rats

Lee SP, Lee KN, Lee OY, Lee HL, Jun DW, Yoon BC, Choi HS, Hwang SJ, Lee SE

  • KMID: 1774540
  • Gut Liver.
  • 2014 Mar;8(2):140-147.
BACKGROUND/AIMS: DA-9701, a standardized extract of Pharbitis Semen and Corydalis Tuber, is a new prokinetic agent that exhibits an analgesic effect on the abdomen. We investigated whether DA-9701 affects visceral...
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Hop Extract Produces Antinociception by Acting on Opioid System in Mice

Park SH, Sim YB, Kang YJ, Kim SS, Kim CH, Kim SJ, Seo JY, Lim SM, Suh HW

In the present study, the antinociceptive profiles of hop extract were characterized in ICR mice. Hop extract administered orally (from 25 to 100 mg/kg) showed an antinociceptive effect in a...
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Olopatadine ophthalmic solution suppresses substance P release in the conjunctivitis models

Tamura T

BACKGROUND: Olopatadine hydrochloride ophthalmic solutions are treated for allergic conjunctival diseases that are a selective histamine H1 receptor antagonist and an inhibitor of the release of mediators including histamine from...
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Effect of Agrimonia pilosa Ledeb Extract on the Antinociception and Mechanisms in Mouse

Park SH, Sim YB, Kang YJ, Lee JK, Lim SS, Suh HW

In the present study, the antinociceptive profiles of Agrimonia pilosa Ledeb extract were examined in ICR mice. Agrimonia pilosa Ledeb extract administered orally (200 mg/kg) showed an antinociceptive effect as...
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Silk Fibroin and Substance P Combination Graft for the Reconstruction of a Bone Defect

Park KY, Choi KH, Park YJ, Song JY, Kim SG, Jo YY, Kweon HY, Kang SW

  • KMID: 2009670
  • J Korean Assoc Maxillofac Plast Reconstr Surg.
  • 2011 Jul;33(4):293-300.
PURPOSE: Substance P is a well known neurotransmitter and has been known to mediate pain. Recently, it has been unveiled that substance P is involved in the recruitment of mesenchymal...
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