Korean J Clin Pathol.  1999 Aug;19(4):414-419.

Abnormalities of Serum Lipid, Lipoprotein and Apolipoprotein in Both Normotriglyceridemic and Hypertriglyceridemic Patients with Chronic Renal Failure on Chronic Hemodialysis

• Cho KS
• Choi GR
• Kee SJ
• Kim SH
• Shin MG
• Shin JH
• Suh SP
• Ryang DW

Abstract

BACKGROUND
Hypertriglyceridemia (HTG) has been considered a characteristic plasma lipid abnormality in hemodialysis patients with chronic renal failure, but is actually shown in only some of them (30-50%). Also renal dyslipidemia may contribute to atherosclerosis in hemodialysis patients.
METHODS
Study population consisted of 34 patients with normotriglyceridemia (NTG), 11 patients with HTG and 47 controls. We measured total cholesterol (TC), triglyceride (TG), high density lipoprotein-cholesterol (HDL-C), apolipoprotein (apo) A-I, apoB, apoC-III and apoE.
RESULTS
Compared with controls, the NTG patients had significantly decreased levels of TC, HDL-C, and low density lipoprotein-cholesterol (LDL-C). But HTG patients had significantly increased TG, and TC/HDL-C ratio which were considered to represent the atherogenic indicator and had decreased HDL-C and LDL-C (P <0.001), with significant increase of TG and TC/HDL-C ratio compared with those of NTG patients. In the apolipoprotein profiles, all patients showed decreased levels of apoA-I, apoB, and apoA-I/apoC-III ratio and increased levels of apoC-III and apoC-III/apoE ratio compared with those of controls (P <0.001). Especially, HTG patients had significantly increased levels of apoC-III compared with NTG patients.
CONCLUSIONS
So these results indicated that abnormalities of those potentially atherogenic lipid and lipoproteins may contribute to the high incidence of cardiovascular diseases and progression of renal disease in the HTG patients than NTG patients on maintenance hemodialysis.

Keyword

Hypertriglyceridemia; Chronic renal failure; Lipid; Lipoprotein; Apolipoprotein

MeSH Terms

Apolipoprotein A-I
Apolipoprotein C-III
Apolipoproteins B
Apolipoproteins E
Apolipoproteins*
Atherosclerosis
Cardiovascular Diseases
Cholesterol
Dyslipidemias
Humans
Hypertriglyceridemia
Incidence
Kidney Failure, Chronic*
Lipoproteins*
Plasma
Renal Dialysis*
Triglycerides
Apolipoprotein A-I
Apolipoprotein C-III
Apolipoproteins
Apolipoproteins B
Apolipoproteins E
Cholesterol
Lipoproteins