- Development and Application of a Cell-Based Assay for LRP4 Antibody Associated With Myasthenia Gravis
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Chung HY, Kim MJ, Kim SW, Oh J, Shin HY
- KMID: 2537185
- J Clin Neurol.
- 2023 Jan;19(1):60-66.
- doi: 10.3988/jcn.2023.19.1.60
Background and Purpose Among patients with double-seronegative myasthenia gravis (dSN-MG) who do not have detectable antibodies against acetylcholine receptor or musclespecific tyrosine kinase, autoantibodies against low-density lipoprotein receptor-related protein 4... -
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- New Therapeutic Approaches to the Treatment of Dyslipidemia 2: LDL-C and Lp(a)
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Kim KA, Park HJ
- KMID: 2539214
- J Lipid Atheroscler.
- 2023 Jan;12(1):37-46.
- doi: 10.12997/jla.2023.12.1.37
Dyslipidemia is an important risk factor for atherosclerotic cardiovascular disease (ASCVD). There are abundant and unequivocal data to indicate that low-density lipoproteins (LDL) are a cause of ASCVD. Reduction of plasma... -
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- New Therapeutic Approaches to the Treatment of Dyslipidemia 1: ApoC-III and ANGPTL3
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Kim JY, Kim NH
- KMID: 2539212
- J Lipid Atheroscler.
- 2023 Jan;12(1):23-36.
- doi: 10.12997/jla.2023.12.1.23
Low-density lipoprotein cholesterol (LDL-C)-lowering therapy that increases LDL receptor expression in several ways robustly reduces the risk of atherosclerotic cardiovascular disease (CVD). However, a substantial risk of CVD still remains... -
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- 2022 Consensus Statement on the Management of Familial Hypercholesterolemia in Korea
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Lee CJ, Yoon M, Kang HJ, Kim BJ, Choi SH, Jeong IK, Lee SH, on behalf of Task Force Team for Familial Hypercholesterolemia, Korean Society of Lipid and Atherosclerosis
- KMID: 2536631
- Korean J Med.
- 2022 Dec;97(6):339-352.
- doi: 10.3904/kjm.2022.97.6.339
Familial hypercholesterolemia (FH) is the most common monogenic disorder. Due to the marked elevation of cardiovascular risk, the early detection, diagnosis, and proper management of this disorder are critical. Herein,... -
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- Low Serum Level of High-density Lipoprotein Cholesterol Is Associated with Gastric Cancer Regardless of Sex and Tumor Stage
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Nam SY, Jeong J, Lee WK, Jeon SW
- KMID: 2533115
- Korean J Helicobacter Up Gastrointest Res.
- 2022 Sep;22(3):222-230.
- doi: 10.7704/kjhugr.2022.0023
Background/Aims: HDL cholesterol (HDL-C) may have anti-tumor effects; however, the effects remain unclear. Thus, this study aimed to investigate sex- and tumor stage-specific association of hyperglycemia and HDL-C with gastric... -
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- A New Modality in Dyslipidemia Treatment: Antisense Oligonucleotide Therapy
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Kim K, Choi SH
- KMID: 2533270
- J Lipid Atheroscler.
- 2022 Sep;11(3):250-261.
- doi: 10.12997/jla.2022.11.3.250
There are unmet needs for pharmacologic agents beyond current medications, such as statins, to effectively lower low-density lipoprotein cholesterol levels to target goals, especially in patients with very high or... -
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- 2022 Consensus statement on the management of familial hypercholesterolemia in Korea
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Lee CJ, Yoon M, Kang HJ, Kim BJ, Choi SH, Jeong IK, Lee SH, on behalf of Task Force Team for Familial Hypercholesterolemia, Korean Society of Lipid and Atherosclerosis
- KMID: 2533135
- Korean J Intern Med.
- 2022 Sep;37(5):931-944.
- doi: 10.3904/kjim.2022.121
Familial hypercholesterolemia (FH) is the most common monogenic disorder. Due to the marked elevation of cardiovascular risk, the early detection, diagnosis, and proper management of this disorder are critical. Herein,... -
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- 2022 Consensus Statement on the Management of Familial Hypercholesterolemia in Korea
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Lee CJ, Yoon M, Kang HJ, Kim BJ, Choi SH, Jeong IK, Lee SH, oboTFTfFHKSoLaA
- KMID: 2533272
- J Lipid Atheroscler.
- 2022 Sep;11(3):213-228.
- doi: 10.12997/jla.2022.11.3.213
Familial hypercholesterolemia (FH) is the most common monogenic disorder. Due to the marked elevation of cardiovascular risk, the early detection, diagnosis, and proper management of this disorder are critical. Herein,... -
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- Impact of Severe Hypercholesterolemia on Cardiovascular Risk in Individuals With or Without Diabetes Mellitus
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Lee CJ, Park S, Han K, Lee SH
- KMID: 2533265
- J Lipid Atheroscler.
- 2022 Sep;11(3):299-307.
- doi: 10.12997/jla.2022.11.3.299
Objective: The aim of the current study was to investigate whether the impact of low-density lipoprotein-cholesterol (LDL-C) levels on cardiovascular risk is different between individuals with severe hypercholesterolemia and diabetes... -
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- Myocardial Infarction, Stroke, and All-Cause Mortality according to Low-Density Lipoprotein Cholesterol Level in the Elderly, a Nationwide Study
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Lee YB, Koo M, Noh E, Hwang SY, Kim JA, Roh E, Hong Sh, Choi KM, Baik SH, Cho GJ, Yoo HJ
- KMID: 2533641
- Diabetes Metab J.
- 2022 Sep;46(5):722-732.
- doi: 10.4093/dmj.2021.0225
Background: We assessed the myocardial infarction (MI), stroke, and all-cause death risks during follow-up according to the low-density lipoprotein cholesterol (LDL-C) levels among older adults. Methods: The Korean National Health Insurance... -
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- Lipoprotein Lipase: Is It a Magic Target for the Treatment of Hypertriglyceridemia
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Moon JH, Kim K, Choi SH
- KMID: 2532857
- Endocrinol Metab.
- 2022 Aug;37(4):575-586.
- doi: 10.3803/EnM.2022.402
High levels of triglycerides (TG) and triglyceride-rich lipoproteins (TGRLs) confer a residual risk of cardiovascular disease after optimal low-density lipoprotein cholesterol (LDL-C)–lowering therapy. Consensus has been made that LDL-C is... -
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- New, Novel Lipid-Lowering Agents for Reducing Cardiovascular Risk: Beyond Statins
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Kim K, Ginsberg HN, Choi SH
- KMID: 2531956
- Diabetes Metab J.
- 2022 Jul;46(4):517-532.
- doi: 10.4093/dmj.2022.0198
Statins are the cornerstone of the prevention and treatment of atherosclerotic cardiovascular disease (ASCVD). However, even under optimal statin therapy, a significant residual ASCVD risk remains. Therefore, there has been... -
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- Association of Lipids, Lipoproteins, and Apolipoproteins with Stroke Subtypes in an International Case Control Study (INTERSTROKE)
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O’Donnell MJ, McQueen M, Sniderman A, Pare G, Wang X, Hankey GJ, Rangarajan S, Chin SL, Rao-Melacini P, Ferguson J, Xavier D, Lisheng L, Zhang H, Pais P, Lopez-Jaramillo P, Damasceno A, Langhorne P, Rosengren A, Dans AL, Elsayed A, Avezum A, Mondo C, Judge C, Diener HC, Ryglewicz D, Czlonkowska A, Pogosova N, Weimar C, Iqbal R, Diaz R, Yusoff K, Yusufali A, Oguz A, Penaherrera E, Lanas F, Ogah OS, Ogunniyi A, Iversen HK, Malaga G, Rumboldt Z, Oveisgharan S, Al Hussain F, Nilanont Y, Yusuf S, on Behalf of the INTERSTROKE Investigators
- KMID: 2530525
- J Stroke.
- 2022 May;24(2):224-235.
- doi: 10.5853/jos.2021.02152
Background and Purpose The association of dyslipidemia with stroke has been inconsistent, which may be due to differing associations within etiological stroke subtypes. We sought to determine the association of... -
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- Association of High-Density Lipoprotein Cholesterol Phenotypes with the Risk of Cardiovascular Diseases and Mortality: A Cohort Study in Korea
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Nam GE, Huh Y, Jung JH, Han K, Kim SM, on Behalf of the Taskforce Team of the Obesity Fact Sheet of the Korean Society for the Study of Obesity
- KMID: 2529218
- Endocrinol Metab.
- 2022 Apr;37(2):261-271.
- doi: 10.3803/EnM.2021.1259
Background: We investigated whether low high-density lipoprotein cholesterol (HDL-C) and isolated and non-isolated low HDL-C levels are associated with the risk of cardiovascular diseases and all-cause mortality among Korean adults. Methods:... -
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- Loss-of-function mutation in Pcsk1 increases serum APOA1 level and LCAT activity in mice
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Khan AA, Kim N, Korstanje R, Choi S
- KMID: 2527819
- Lab Anim Res.
- 2022 Mar;38(1):18-26.
- doi: 10.1186/s42826-021-00111-2
Background: The convertase subtilisin/kexin family 1 gene (PCSK1) has been associated in various human genetics studies with a wide spectrum of metabolic phenotypes, including early-onset obesity, hyperphagia, diabetes insipidus, and... -
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- Mean and Variability of Lipid Measurements and Risk for Development of Subclinical Left Ventricular Diastolic Dysfunction
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Park J, Kang M, Ahn J, Kim MY, Choi MS, Lee YB, Kim G, Hur KY, Kim JH, Yang JH, Jin SM
- KMID: 2527721
- Diabetes Metab J.
- 2022 Mar;46(2):286-296.
- doi: 10.4093/dmj.2021.0080
Background: Subclinical left ventricular diastolic dysfunction (LVDD) is an emerging consequence of increased insulin resistance, and dyslipidemia is one of the few correctable risk factors of LVDD. This study evaluated... -
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- Serum Low-Density Lipoprotein Cholesterol Levels and Depressive Mood in Korean Adults: A Nationwide Population-Based Study
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Jo SY, Kwon YJ, Cho AR
- KMID: 2524978
- Korean J Fam Med.
- 2022 Jan;43(1):63-68.
- doi: 10.4082/kjfm.21.0102
Background: The association between serum cholesterol levels and depression has been studied extensively; however, results are inconsistent. This study aimed to investigate the association between low-density lipoprotein cholesterol (LDL-C) levels... -
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- Individualized Treatment for Patients With Familial Hypercholesterolemia
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Tada H, Takamura M, Kawashiri Ma
- KMID: 2525236
- J Lipid Atheroscler.
- 2022 Jan;11(1):39-54.
- doi: 10.12997/jla.2022.11.1.39
Familial hypercholesterolemia (FH) is one of the most common and, therefore, important inherited disorders in preventive cardiology. This disease is mainly caused by a single pathogenic mutation in the low-density... -
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- Combination of High-Density Lipoprotein Cholesterol and Lipoprotein(a) as a Predictor of Collateral Circulation in Patients With Severe Unilateral Internal Carotid Artery Stenosis or Occlusion
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Ma S, Zhang M, Qu H, Cheng Y, Du S, Fan J, Yao Q, Zhang X, Chen M, Zhang N, Shi K, Huang Y, Zhan S
- KMID: 2524548
- J Clin Neurol.
- 2022 Jan;18(1):14-23.
- doi: 10.3988/jcn.2022.18.1.14
Background and Purpose Collateral circulation is considered an important factor affecting the risk of stroke, but the factors that affect collateral circulation remain unclear. This study was performed to identify... -
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- The Effects of PPAR Agonists on Atherosclerosis and Nonalcoholic Fatty Liver Disease in ApoE−/−FXR−/− Mice
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Lee Y, Kim BR, Kang GH, Lee GJ, Park YJ, Kim H, Jang HC, Choi SH
- KMID: 2523493
- Endocrinol Metab.
- 2021 Dec;36(6):1243-1253.
- doi: 10.3803/EnM.2021.1100
Background: Farnesoid X receptor (FXR), a bile acid–activated nuclear receptor, is a potent regulator of glucose and lipid metabolism as well as of bile acid metabolism. Previous studies have demonstrated... -
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