J Korean Surg Soc.  1997 Aug;53(2):287-293.

A Case of Multiple Endocrine Neoplasia Type 1

• Lee DS
• Song MH
• Kim W
• Park IY
• Won JM

Abstract

In 1903 Erdheim reported multiple endocrine neoplasia type 1 (MEN 1) by autopsy, and in 1954 Wermer reported a familial occurrence of multiple tumors which were associated with neoplastic transformation of parathyroid, pituitary and pancreatic islet cells. This complex association of abnormalities is inherited as an autosomal dominant trait and related to tumor suppressor gene on chromosome 11. In a 38-year-old woman with epigastric discomfort, general weakness and mental change, a pituitary gland tumor was diagnosed with sella magnetic resonance imaging and combined pituitary stimulation test. a pancreas insulinoma, an adrenal gland cortical adenoma and a thyroid adenoma were confirmed by pathology and they were diagnosed with biochemical test, CT scan, percutaneous transhepatic portal vein catheterization with insulin sampling, thyroid sonogram and scintigram. The blood glucose level was normalized after operation. In the 6 months follow up study, she has not presented any symptoms of hypoglycemia so far. Authors present this case briefly with a review of literature.

Keyword

MEN 1; Insulinoma; Thyroid adenoma; Adrenal cortical adenoma

MeSH Terms

Adenoma
Adrenal Glands
Adrenocortical Adenoma
Adult
Autopsy
Blood Glucose
Catheterization
Catheters
Chromosomes, Human, Pair 11
Female
Follow-Up Studies
Genes, Tumor Suppressor
Humans
Hypoglycemia
Insulin
Insulinoma
Islets of Langerhans
Magnetic Resonance Imaging
Multiple Endocrine Neoplasia Type 1*
Multiple Endocrine Neoplasia*
Pancreas
Pathology
Pituitary Gland
Portal Vein
Thyroid Gland
Thyroid Neoplasms
Tomography, X-Ray Computed
Blood Glucose
Insulin