- Upregulated Long Noncoding RNA LINC01234 Predicts Unfavorable Prognosis for Colorectal Cancer and Negatively Correlates With KLF6 Expression
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Jiang X, Zhu Q, Wu P, Zhou F, Chen J
- KMID: 2460913
- Ann Lab Med.
- 2020 Mar;40(2):155-163.
- doi: 10.3343/alm.2020.40.2.155
BACKGROUND: LINC01234, a long noncoding RNA (lncRNA), is overexpressed in several cancers, including colorectal cancer (CRC). We investigated the role of LINC01234 in CRC development and confirmed its correlation with... -
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- Genistein Inhibits Proliferation of BRCA1 Mutated Breast Cancer Cells: The GPR30-Akt Axis as a Potential Target
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Kim GY, Suh J, Jang JH, Kim DH, Park OJ, Park SK, Surh YJ
- KMID: 2468809
- J Cancer Prev.
- 2019 Dec;24(4):197-207.
- doi: 10.15430/JCP.2019.24.4.197
BACKGROUND: BRCA1 mutated breast cancer cells exhibit the elevated cell proliferation and the higher metastatic potential. G protein-coupled receptor 30 (GPR30) has been shown to regulate growth of hormonally responsive... -
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- Usefulness of Chromosomal Microarray in Hematologic Malignancies: A Case of Aggressive NK-cell Leukemia with 1q Abnormality
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Chung YN, Kim HN, Lee SR, Sung HJ, Nam MH
- KMID: 2450847
- Lab Med Online.
- 2019 Jul;9(3):189-193.
- doi: 10.3343/lmo.2019.9.3.189
A variety of clonal cytogenetic abnormalities have been reported in aggressive natural killer (NK)-cell lymphoma and leukemia. Recent chromosomal microarray studies have shown both gain and loss of 1q and... -
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- Clinical significance of variants of unknown significances in BRCA genes
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Choi MC
- KMID: 2450245
- J Gynecol Oncol.
- 2019 Jul;30(4):e80.
- doi: 10.3802/jgo.2019.30.e80
No abstract available. -
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- The Roles of miRNAs in Medulloblastoma: A Systematic Review
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Mollashahi B, Aghamaleki FS, Movafagh A
- KMID: 2454668
- J Cancer Prev.
- 2019 Jun;24(2):79-90.
- doi: 10.15430/JCP.2019.24.2.79
Medulloblastoma is considered one of the most threatening malignant brain tumors with an extremely high mortality rate in children. In the medulloblastoma, there are several genes and mutations found to... -
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- Expression of NF2 Modulates the Progression of BRAFV600E Mutated Thyroid Cancer Cells
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You MH, Jeon MJ, Kim TY, Kim WB, Shong YK, Kim WG
- KMID: 2450521
- Endocrinol Metab.
- 2019 Jun;34(2):203-212.
- doi: 10.3803/EnM.2019.34.2.203
BACKGROUND: We previously reported the frequent neurofibromatosis 2 (NF2) gene mutations in anaplastic thyroid cancers in association with the BRAF V600E mutation. We aimed to investigate the role of NF2 in... -
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- Overexpression of Tumor Protein p53-regulated Apoptosis-inducing Protein 1 Regulates Proliferation and Apoptosis of Breast Cancer Cells through the PI3K/Akt Pathway
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Liang Y, Wang S, Liu J
- KMID: 2450113
- J Breast Cancer.
- 2019 Jun;22(2):172-184.
- doi: 10.4048/jbc.2019.22.e21
PURPOSE: Tumor protein p53-regulated apoptosis-inducing protein 1 (TP53AIP1) functions in various cancers. We studied the effect and molecular mechanism of TP53AIP1 in breast cancer. METHODS: The degree of correlation between TP53AIP1... -
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- Effect of PTEN Polymorphism on the Development of Hepatitis B Virus-associated Hepatocellular Carcinoma
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Kim SS, Eun JW, Cho HJ, Lee HY, Seo CW, Lee GH, Yoon SY, Noh CK, Cho SW, Cheong JY
- KMID: 2448276
- J Liver Cancer.
- 2019 Mar;19(1):46-54.
- doi: 10.17998/jlc.19.1.46
BACKGROUND/AIMS: Phosphatase and tensin homolog (PTEN) is a known tumor suppressor gene that is downregulated in hepatocellular carcinoma (HCC). Here, we investigated the association between single nucleotide polymorphisms (SNPs) of... -
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- PTEN Mutation Identified in Patient Diagnosed with Simultaneous Multiple Cancers
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Won HS, Chang ED, Na SJ, Whang IY, Lee DS, You SH, Kim YS, Kim JS
- KMID: 2437630
- Cancer Res Treat.
- 2019 Jan;51(1):402-407.
- doi: 10.4143/crt.2017.579
PTEN hamartoma tumor syndrome is a spectrum of disorders characterized by unique phenotypic features including multiple hamartomas caused by mutations of the tumor suppressor gene PTEN. Cowden syndrome and Bannayan–Riley–Ruvalcaba... -
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- Disruption of the Tff1 gene in mice using CRISPR/Cas9 promotes body weight reduction and gastric tumorigenesis
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Kim H, Jeong H, Cho Y, Lee J, Nam KT, Lee HW
- KMID: 2459303
- Lab Anim Res.
- 2018 Dec;34(4):257-263.
- doi: 10.5625/lar.2018.34.4.257
Trefoil factor 1 (TFF1, also known as pS2) is strongly expressed in the gastrointestinal mucosa and plays a critical role in the differentiation of gastric glands. Since approximately 50% of... -
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- Somatic Mutations from Whole Exome Sequencing Analysis of the Patients with Biliary Tract Cancer
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Yoon KA, Woo SM, Kim YH, Kong SY, Han SS, Park SJ, Lee WJ
- KMID: 2439225
- Genomics Inform.
- 2018 Dec;16(4):e35.
- doi: 10.5808/GI.2018.16.4.e35
Biliary tract cancer (BTC) is a rare cancer and is associated with a poor prognosis. To understand the genetic characteristics of BTC, we analyzed whole-exome sequencing data and identified somatic... -
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- Differences Regarding the Molecular Features and Gut Microbiota Between Right and Left Colon Cancer
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Kim K, Castro EJ, Shim H, Advincula , Kim YW
- KMID: 2434373
- Ann Coloproctol.
- 2018 Dec;34(6):280-285.
- doi: 10.3393/ac.2018.12.17
For many years, developmental and physiological differences have been known to exist between anatomic segments of the colorectum. Because of different outcomes, prognoses, and clinical responses to chemotherapy, the distinction... -
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- Cancer Metabolism as a Mechanism of Treatment Resistance and Potential Therapeutic Target in Hepatocellular Carcinoma
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Lee M, Ko H, Yun M
- KMID: 2426327
- Yonsei Med J.
- 2018 Dec;59(10):1143-1149.
- doi: 10.3349/ymj.2018.59.10.1143
Various molecular targeted therapies and diagnostic modalities have been developed for the treatment of hepatocellular carcinoma (HCC); however, HCC still remains a difficult malignancy to cure. Recently, the focus has... -
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- Relation between RASSF1A Methylation and BRAF Mutation in Thyroid Tumor
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Oh KH, Jung KY, Baek SK, Woo JS, Cho JG, Kwon SY
- KMID: 2448982
- Int J Thyroidol.
- 2018 Nov;11(2):123-129.
- doi: 10.11106/ijt.2018.11.2.123
BACKGROUND AND OBJECTIVES: Hypermethylation of the tumor suppressor gene RASSF1A and activating mutation of BRAF gene have been recently reported in thyroid cancers. To investigate the role of these two... -
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- Deficiency of Follistatin-Like Protein 1 Accelerates the Growth of Breast Cancer Cells at Lung Metastatic Sites
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Zhang Y, Xu X, Yang Y, Ma J, Wang L, Meng X, Chen B, Qin L, Lu T, Gao Y
- KMID: 2421367
- J Breast Cancer.
- 2018 Sep;21(3):267-276.
- doi: 10.4048/jbc.2018.21.e43
PURPOSE: Follistatin-like protein 1 (FSTL1) is a secreted glycoprotein that has been shown to play a role in various types of cancer. However, the clinical significance and function of FSTL1... -
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- Serrated neoplasia pathway as an alternative route of colorectal cancer carcinogenesis
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Kim SY, Kim TI
- KMID: 2417647
- Intest Res.
- 2018 Jul;16(3):358-365.
- doi: 10.5217/ir.2018.16.3.358
In the past two decades, besides conventional adenoma pathway, a subset of colonic lesions, including hyperplastic polyps, sessile serrated adenoma/polyps, and traditional serrated adenomas have been suggested as precancerous lesions... -
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- Clinical and Prognostic Significance of Oâ¶-Methylguanine-DNA Methyltransferase Promoter Methylation in Patients with Melanoma: A Systematic Meta-Analysis
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Qi F, Yin Z, Wang G, Zeng S
- KMID: 2414672
- Ann Dermatol.
- 2018 Apr;30(2):129-135.
- doi: 10.5021/ad.2018.30.2.129
Tumor suppressor gene Oâ¶-methylguanine-DNA methyltransferase (MGMT) promoter methylation has been reported in melanoma. However, the clinical and prognostic significance of MGMT promoter methylation in patients with melanoma remained to be... -
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- Epigenetic inactivation of RUNX3 in colorectal cancer
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Shin EJ, Kim HJ, Son MW, Ahn TS, Lee HY, Lim DR, Bae SB, Jeon S, Kim H, Jeong D, Lee MS, Kim DS, Noh JS, Baek MJ
- KMID: 2405335
- Ann Surg Treat Res.
- 2018 Jan;94(1):19-25.
- doi: 10.4174/astr.2018.94.1.19
PURPOSE: Emerging evidence indicates that runt-related transcription factor 3 (RUNX3) is an important tumor suppressor gene in several cancer types, including colorectal cancer (CRC). However, the clinical significance of RUNX3... -
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- TP53 R72P Polymorphism and Susceptibility to Human Papillomavirus Infection Among Women With Human Immunodeficiency Virus in Morocco: A Case-control Study
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Lahsen AO, Baba H, Bensghir R, Fayssel N, Sodqi M, Marih L, Nadifi S, Wakrim L, El Filali , Ezzikouri
- KMID: 2434287
- J Cancer Prev.
- 2017 Dec;22(4):248-253.
- doi: 10.15430/JCP.2017.22.4.248
BACKGROUND: Human papillomavirus (HPV) is the most common sexually transmitted agent worldwide. HPV is the main causative agent for cervical cancer. The HPV oncoprotein E6 binds to the tumor suppressor... -
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- Clinicopathological Significance of Large Tumor Suppressor (LATS) Expression in Gastric Cancer
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Son MW, Song GJ, Jang SH, Hong SA, Oh MH, Lee JH, Baek MJ, Lee MS
- KMID: 2398802
- J Gastric Cancer.
- 2017 Dec;17(4):363-373.
- doi: 10.5230/jgc.2017.17.e41
PURPOSE: The aims of this study were to evaluate the expression of the large tumor suppressor (LATS) genes LATS1 and LATS2 by immunohistochemical staining of gastric cancer, and to evaluate... -
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