- The Immunohistochemical Study of Oncogene and Tumor Suppressor Gene Proteins on Bone Tumor
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Kim MK, Yeom BW, Lee JH
- KMID: 2105099
- J Korean Orthop Assoc.
- 1997 Jun;32(3):623-631.
The discovery of oncogenes and tumor suppressor genes have made it possible to partly understand the mechanism of cancer development. It is generally accepted that the cancer development is caused... -
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- Cancer Metastasis and Metastasis Suppressors
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Song IH
- KMID: 1111502
- Korean J Gastroenterol.
- 2004 Jan;43(1):1-7.
Cancer metastasis, a complex and sequential network of cellular events involved in the migration and establishment of malignant cells from original site to distant foci, is an important and significant... -
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- Diffuse Large B Cell Lymphoma Shows Distinct Methylation Profiles of the Tumor Suppressor Genes among the Non-Hodgkin's Lymphomas
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Yoon SO, Kim YA, Jeon YK, Kim JE, Kang GH, Kim CW
- KMID: 1163280
- Korean J Pathol.
- 2008 Feb;42(1):16-20.
BACKGROUND: Aberrant methylation of CpG islands in promoter regions is one of the major mechanisms for silencing of tumor suppressor genes in various types of human cancers including non-Hodgkin's... -
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- Mutations of p53 tumor suppressor gene in human lung cancer cell lines
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Hong WS, Hong SI, Lee DS, Son YS, Lee CT
- KMID: 1699963
- Tuberc Respir Dis.
- 1993 Dec;40(6):653-658.
No abstract available. -
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- Identification of Tumor Suppressor Gene in Renal Cell Carcinoma using Arbitrarily Primed-Polymease Chain Reaction (AP-PCR)
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Gu JH, Park JI, KIm IH, Jung SI, Yoon JH
- KMID: 1583477
- Korean J Urol.
- 2000 Aug;41(8):948-953.
No abstract available. -
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- Regulation and Function of the Peg3 Imprinted Domain
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He H, Kim J
- KMID: 2009097
- Genomics Inform.
- 2014 Sep;12(3):105-113.
- doi: 10.5808/GI.2014.12.3.105
A subset of mammalian genes differ functionally between two alleles due to genomic imprinting, and seven such genes (Peg3, Usp29, APeg3, Zfp264, Zim1, Zim2, Zim3) are localized within the 500-kb... -
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- Molecular Pathogenesis of Gastric Cancer
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Park WS
- KMID: 2188286
- J Korean Med Assoc.
- 2010 Apr;53(4):270-282.
- doi: 10.5124/jkma.2010.53.4.270
In this article, I will survey the major genetic susceptibility and somatic genetic alterations involved in gastric cancer and adenoma. These include germline and somatic genetic alterations in oncogenes, tumor... -
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- Gene Methylation Associated with Differentiated Thyroid Cancer
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Tae SY, Chi HK, Kim SJ, Lee KE, Youn YK
- KMID: 2095122
- J Korean Thyroid Assoc.
- 2014 Nov;7(2):118-128.
- doi: 10.11106/cet.2014.7.2.118
Epigenetic alteration changes expression of many genes, such as tumor suppressor gene and molecular specific gene, without change in DNA sequence. Cancers, including thyroid cancer, often exhibit an aberrant methylation... -
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- Analysis of Epigenetic Marker of Bladder Cancer
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Moon WC, Oh MR
- KMID: 2293226
- Korean J Urol.
- 2004 Dec;45(12):1201-1208.
PURPOSE: Promoter methylation provides an alternative pathway for the loss of tumor suppressor gene functions. This epigenetic change is a new marker for human cancers. We herein investigated the aberrant... -
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- Caspase-3/CPP32 Immunoreactivity and Its Correlation with Frequency of Apoptotic Bodies in Prostate Adenocarcinoma and Benign Prostatic Hyperplasia
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Kang DG, Choi NG
- KMID: 1884993
- Korean J Urol.
- 2001 Jul;42(7):707-712.
PURPOSE: Apoptosis is mediated by apoptosis-specific genes, certain oncogenes and tumor suppressor genes. Caspase-3, a group of cysteine proteases, ier in cases with intermediate (Gleason score 5-7) and high-grade (Gleason... -
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- p53 Gene Mutations in Transitional Cell Carcinoma of the Renal Pelvis
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Uhm SY, Kong G, Park HY
- KMID: 1764378
- Korean J Urol.
- 1997 Apr;38(4):368-377.
Inactivation or loss of suppressor genes on a specific chromosome plays an important role in the development and progression of cancer. Recent studies have shown that p53 gene acts as... -
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- Expression of Tumor Suppression Gene in Childhood Cancer
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Lee JE, Lee MI, Park CS
- KMID: 2207970
- J Korean Pediatr Soc.
- 1998 Mar;41(3):383-389.
PURPOSE: Childhood cancer is closely related to the mutation of tumor suppressor gene. The mutant gene may evoke congenital anomaly and development of cancer. The common solid tumors in childhood... -
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- Altered Expression of p53, p21WAF1, p16, Rb, Smad4 and c-erbB-2 in Resected Pancreatic Ductal Adenocarcinoma
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Kang YK, Kim WH
- KMID: 1725937
- Korean J Pathol.
- 2002 Dec;36(6):382-388.
BACKGROUND: Our aim was to undertake a comprehensive analysis of the expression of key molecular markers in a series of pancreatic ductal adenocarcinomas and to determine their association with clinicopathologic... -
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- Multiple Methylator Phenotypes Involving Tumor Suppressor Genes in Ovarian Cancers
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Ryu HC, Cho CH, Kwon SH, Park JC, Seo MA, Chung SW, Rhee JH, Kim JI, Yoon SD, Cha SD
- KMID: 2143469
- Korean J Gynecol Oncol Colposc.
- 2003 Sep;14(3):229-234.
OBJECTIVE: Recent evidence suggests that aberrant methylation of CpG islands is a major pathway leading to the inactivation of tumor suppressor genes and development of cancer. The purpose of this... -
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- Loss of Heterozygosities in Five Tumor Suppressor Genes (FHIT Gene, p16, pRb, E-Cadherin and p53) in Thyroid Tumors
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Kim JH, Choi KY, Lee DJ, Rho YS, Jo SJ
- KMID: 2278408
- Clin Exp Otorhinolaryngol.
- 2014 Mar;7(1):53-58.
OBJECTIVES: To evaluate the loss of heterozygosities (LOH) of chromosomes 3p14 (FHIT gene), 9p21 (p16), 13q21 (pRb), 6q22 (E-cadherin) and 17p13 (p53) in various thyroid tumors. METHODS: Eighty thyroid tumor cases... -
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- Loss of Heterozygosity and Microsatellite Instability at Multiple Tumor Suppressor Genes in Gastric Carcinomas
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Cho YG, Kim CJ, Park CH, Kim YS, Kim SY, Nam SW, Lee SH, Yoo NJ, Lee JY, Park WS
- KMID: 2372736
- J Korean Gastric Cancer Assoc.
- 2003 Dec;3(4):214-220.
PURPOSE: The aim of this study was to investigate the frequency of loss of heterozygosity and the microsatellite instability at multiple tumor suppressor gene loci in gastric adenocarcinomas. MATENRIALS AND METHODS:... -
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- Identification of Zinc Finger Genes that are Differentially Expressed upon Apoptosis of Ramos B Cells
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Shin MS, Kim SY, Dong SM, Na EY, Lee SH, Park WS, Lee JY, Yoo NJ
- KMID: 2275698
- Korean J Pathol.
- 1998 Dec;32(12):1043-1048.
Typical programmed cell death requires de novo macromolecular synthesis and shares common morphological changes referred to as apoptosis. To elucidate the molecular mechanism of apoptosis, we isolated 13 cDNA clones... -
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- Osteosarcoma with Adenocarcinoma of Lung in Li-Fraumeni Syndrome: A Case Report
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Oh CS, Lee JH, Jung ST, Na BR
- KMID: 1799901
- J Korean Bone Joint Tumor Soc.
- 2014 Dec;20(2):99-103.
- doi: 10.5292/jkbjts.2014.20.2.99
Li-Fraumeni syndrome (LFS) is an autosomal dominant hereditary disorder characterised by a variety of different tumor types in children and young adults. That contains with a germline mutation in the... -
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- The Molecular Pathogenesis of Pituitary Adenomas: An Update
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Jiang X, Zhang X
- KMID: 2169301
- Endocrinol Metab.
- 2013 Dec;28(4):245-254.
- doi: 10.3803/EnM.2013.28.4.245
Pituitary tumors represent the most common intracranial neoplasms accompanying serious morbidity through mass effects and inappropriate secretion of pituitary hormones. Understanding the etiology of pituitary tumorigenesis will facilitate the development... -
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- Enhanced Growth inhibition by Combined Gene Transfer of p53 and p16INK4a in Adenoviral Vectors to Lung Cancer Cell Lines
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Choi SH, Park KH, Seol JY, Yoo CG, Lee CT, Kim YW, Han SK, Shim YS
- KMID: 2160057
- Tuberc Respir Dis.
- 2001 Jan;50(1):67-75.
- doi: 10.4046/trd.2001.50.1.67
BACKGROUND: Two tumor suppressor genes, p53 and p16, which have different roles in controlling the cell cycle and inducing apoptosis, are frequently inactivated during carcinogenesis including lung cancer. Single tumor... -
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