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A Case of Asymptomatic Multiple Endocrine Neoplasia Type I with Thymic Carcinoid

Park SK, Lee MW, Han IS, Park YJ, Han SY, Park JW, Lee BE, Kim GH, Kim SS

Multiple endocrine neoplasia type 1 (MEN 1) is an autosomal dominant hereditary disorder caused by germline mutation of the MEN1 gene. It is characterized by tumors of the anterior pituitary...
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Multiple Neuroendocrine Tumors in Stomach and Duodenum in a Multiple Endocrine Neoplasia Type 1 Patient

Kim B, Yang HK, Kim WH

A 67-year-old woman with a history of subtotal parathyroidectomy, distal pancreatectomy, and total splenectomy 23 years prior underwent surgical gastric resection for neuroendocrine tumors of the stomach and duodenum. Meticulous...
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A Case of Multiple Endocrine Neoplasia Type 1 in Type 2 Diabetes Mellitus with Poor Glycemic Control

Lee YH, Lee YC, Lee JE, Lee SJ, Jeong SJ, Kim CH

The primary causes of uncontrolled diabetes are poor life-style, infection, ischemic heart disease and inappropriate usage of oral anti-diabetic agents and insulin. Supplementary causes are stroke, acute pancreatitis and endocrine...
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Pheochromocytoma Developed in a Boy with Multiple Endocrine Neoplasia Type 2A Confirmed by the RET Proto-Oncogene Mutation

Park SY, Jin MJ, Choi EM, Kang SJ, Choi JH, Shim YJ, Kim HS, Jung EY, Lee HJ, Choi MS, Kim HW

A 9-year-old boy presented with increased sweating and abdominal pain. His mother and uncle had been diagnosed with bilateral pheochromocytoma and medullary thyroid carcinoma. Magnetic resonance imaging of the boy's...
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Multiple Endocrine Neoplasia Type 1 Presenting with an Invasive Giant Prolactinoma

Cha J, Kim JS, Han JS, Park YW, Kim MJ, Ku YH, Kim HI

Pituitary tumors occur in 15-50% of patients with multiple endocrine neoplasia of type 1 (MEN1). To the best of our knowledge, no MEN1 case in which the initial lesion was...
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Multiple endocrine neoplasia type 1 with anterior mediastinal parathyroid adenoma: successful localization using Tc-99m sestamibi SPECT/CT

Park HL, Yoo IR, Kim SH, Lee S

The most common manifestation of multiple endocrine neoplasia type 1 (MEN1) is hyperparathyroidism. Treatment of hyperparathyroidism in MEN patients is surgical removal of the parathyroid glands, however ectopic parathyroid gland...
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Multiple Endocrine Neoplasia Type 2B Diagnosed Early by Conjunctival Neuroma: a Case Report

Kim DH, Jang YS, Kang SR, Lim DM

Multiple endocrine neoplasia type 2B (MEN 2B) is an autosomal dominant disorder characterized by medullary thyroid cancer, pheochromocytoma, neuroma and Marfanoid feature. Medullary thyroid cancer occurs in more than 95%...
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Endoscopic Ultrasonography-Guided Ethanol Injection for a Pancreatic Neuroendocrine Tumor with Multiple Endocrine Neoplasia Type 1

An S, Lee JY, Hwang SH, Park DH, Lee SK

Multiple endocrine neoplasia type 1 (MEN1) is a rare inherited disorder caused by mutations in the MEN1 gene on chromosome 1. Clinical diagnostic criteria for MEN1 include the presence of...
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Recurrent hyperparathyroidism due to proliferation of autotransplanted parathyroid tissue in a multiple endocrine neoplasia type 2A patient

Kim BK, Lee J, Sun WY

About 20%–30% of all cases of multiple endocrine neoplasia type 2A (MEN 2A) is accompanied by primary hyperparathyroidism. These patients undergo parathyroidectomy and, if needed, autotransplantation. In rare cases, autotransplanted...
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Two Cases of Multiple Endocrine Neoplasia Type II with RET Mutaion

Yoo SY, Choi YH, Lee MK, Kim MS, Hwang PH

Multiple endocrine neoplasia type 2(MEN2) is a rare autosomal dominant inherited disorder characterized by the presence of medullary thyroid carcinoma, pheochromocytoma and other hyperplasia and/or neoplasia of different endocrine tissues...
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Early Symptoms and Clinical Manifestations in Korean Patients with Multiple Endocrine Neoplasia

Kim KH, Koo MY, Hur SM, Lee SK, Choe JH, Lee JE, Kim JS, Chung JH, Nam SJ, Yang JH, Kim JH

PURPOSE: Multiple endocrine neoplasia (MEN) syndrome is an inherited, autosomal dominant disease that presents as a combination of several endocrine tumors. Early diagnosis of this syndrome is difficult, because of...
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A Family of Multiple Endocrine Neoplasia Type 2A with a C634R Mutation and a G691S Polymorphism in RET Proto-oncogene

Yun SW, Yoo WS, Hong KH, Kim BH, Kang MH, Choo YK, Park HY, Kim DH, Chung HK, Chang MC, Kwon MS, Kim HJ

Multiple endocrine neoplasia type 2A (MEN2A) is an autosomal dominant syndrome characterized by the presence of a medullary thyroid carcinoma, pheochromocytoma and hyperparathyroidism. MEN2A arises due to germline missense mutations...
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Analysis of RET Gene Point Mutation in a Family with Multiple Endocrine Neoplasia Type 2A

Kim SW, Lee KD, Kim JY, Moon HS, Kim YR, Park YH, Lee KS

  • KMID: 2276772
  • Korean J Otolaryngol-Head Neck Surg.
  • 2007 Jun;50(6):529-536.
BACKGROUND AND OBJECTIVES: Multiple Endocrine Neoplasia type 2A (MEN 2A) is a syndrome that encompasses medullary thyroid carcinoma, pheochromocytoma, and hyperparathyroidism. Since MEN 2A is inherited as autosomal dominant, early...
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A Case of Familial Multiple Endocrine Neoplasia Type 1 with MEN1 Gene Mutation

Jo YE, Choi YJ, Kim YK, Ahn SM, Jung SH, Kim HJ, Kim DJ, Lee KW, Hong JH, Jeong SY, Kim HJ, Chung YS

Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant disorder characterized by the combined occurrence of parathyroid, pancreatic islet and pituitary gland tumors. It is caused by mutation of...
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A Case of Familial Multiple Endocrine Neoplasia with MEN1 Gene Mutation

Sung HY, Chun YJ, Lee H, Kwon BJ, Park KW, Lee JM, Moon SD, Chang SA, Han JH

  • KMID: 2391913
  • J Korean Endocr Soc.
  • 2006 Dec;21(6):560-566.
Multiple endocrine neoplasia type 1 (MEN 1) is an autosomal dominant disorder that's characterized by the combined occurrence of primary hyperparathyroidism, endocrine pancreatic tumors and anterior pituitary adenomas, but such...
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A Case of Multiple Endocrine Neoplasia Type 2B early Diagnosis by RET Proto-oncogene Analysis and Prophylactic Total Thyroidectomy

Kim BS, Rhie YJ, Koh H, Kim DH, Choi SH

  • KMID: 1510419
  • J Korean Soc Pediatr Endocrinol.
  • 2006 Jun;11(1):104-109.
Multiple endocrine neoplasia type 2B (MEN 2B) is a rare autosomal-dominant hereditary syndrome which includes medullary thyroid carcinoma (MTC), pheochoromocytoma, multiple ganglioneuromas, gastrointestinal disorders and marfanoid face. MTC is the...
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A family of multiple endocrine neoplasia type 2A associated with a C618R mutation in RET proto-oncogene

Kim NH, Kim JH, Nam JH, Park JP, Park JE, Choi YS, Park YH

  • KMID: 1833332
  • Korean J Med.
  • 2006 Apr;70(4):448-454.
Medullary thyroid carcinoma (MTC) is a relatively rare malignant thyroid disease that accounts for approximately 1% to 5% of all thyroid carcinomas. MTC occurs as a sporadic disease and as...
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A Case of Multiple Endocrine Neoplasia Type 1 with Papillary Thyroid Carcinoma

Kim HJ, Kim CS, Je HC, Park J, Park JS, Kong JH, Kang ES, Ahn CW, Cha BS, Lim SK, Kim KR, Lee HC, Jang HS, Hong SW

This is the first report of papillary thyroid carcinoma combined with multiple endocrine neoplasia type 1 (MEN 1). It is an hereditary syndrome characterized by neoplastic disorders such as pituitary...
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A case of multiple endocrine neoplasia type 1 with thymic carcinoid tumor

Cho M, Lee KM, Song DH, Ahn CW, Kim KR, Hwang JJ, Baek HC

  • KMID: 2081157
  • Korean J Med.
  • 2005 Oct;69(4):428-433.
Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant tumor syndrome. Thymic carcinoid tumors in MEN1 are not common and their natural history is little known. But development of...
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The Characteristics of Multiple Endocrine Neoplasia in Korean

Yang JH, Woo SU

PURPOSE: Multiple Endocrine Neoplasm (MEN) is a rare, complex and familial disease. There are MEN syndromes are inherited in an autosomal dominant fashion with high penetrance. The variations in the...
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