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First experience of pancreaticoduodenectomy using Revo-i in a patient with insulinoma

Kang I, Hwang HK, Lee WJ, Kang CM

Robotic surgery systems have been developed to overcome the limitations of laparoscopic surgery. Recently, Meerecompany Inc. in Korea successfully manufactured a robotic surgical system called Revo-i. A 65-year old woman...
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Metastatic Insulinoma Presenting as a Liver Cyst

Li H, Jabbour TE, Nigam A, Lee H

No abstract available.
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Deficiency of Sphingosine-1-Phosphate Reduces the Expression of Prohibitin and Causes β-Cell Impairment via Mitochondrial Dysregulation

Hong SW, Lee J, Kwon H, Park SE, Rhee EJ, Park CY, Oh KW, Park SW, Lee WY

BACKGROUND: Emerging evidence suggests that sphingolipids may be involved in type 2 diabetes. However, the exact signaling defect through which disordered sphingolipid metabolism induces β-cell dysfunction remains unknown. The current...
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Pioglitazone Attenuates Palmitate-Induced Inflammation and Endoplasmic Reticulum Stress in Pancreatic β-Cells

Hong SW, Lee J, Cho JH, Kwon H, Park SE, Rhee EJ, Park CY, Oh KW, Park SW, Lee WY

BACKGROUND: The nuclear receptor peroxisome proliferator-activator gamma (PPARγ) is a useful therapeutic target for obesity and diabetes, but its role in protecting β-cell function and viability is unclear. METHODS: To identify...
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In Vitro Effect of Fatty Acids Identified in the Plasma of Obese Adolescents on the Function of Pancreatic β-Cells

Velasquez , Vasquez JS, Balcazar N

BACKGROUND: The increase in circulating free fatty acid (FFA) levels is a major factor that induces malfunction in pancreatic β-cells. We evaluated the effect of FFAs reconstituted according to the...
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Insulin autoimmune syndrome associated with alpha-lipoic acid in a young woman with no concomitant disease

Lee SB, Lee MY, You JH, Kim SH, Nam JS

Insulin autoimmune syndrome (IAS) is characterized by spontaneous hypoglycemia, extremely high serum insulin levels, and high titers of autoantibodies against endogenous insulin, in the absence of exogenous insulin injection. IAS...
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Beneficial Effect of Lespedeza cuneata (G. Don) Water Extract on Streptozotocin-induced Type 1 Diabetes and Cytokine-induced Beta-cell Damage

Kim MS, Sharma BR, Rhyu DY

The aim of this study was to evaluate the anti-diabetic effects of the water extract of Lespedeza cuneata (LCW) using rat insulinoma (RIN) m5F cells and streptozotocin (STZ)-induced diabetic rats....
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Successful Endoscopic Ultrasound-Guided Alcohol Ablation of Sporadic Insulinoma Using Three-Dimensional Targeting (with Video)

Trikudanathan G, Mallery SJ, Amateau SK

Surgical resection is considered the standard of care in the management of symptomatic insulinoma. In this video, we describe the successful management of a symptomatic insulinoma by using linear array...
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Multiple Endocrine Neoplasia Type 1 Presenting as Hypoglycemia due to Insulinoma

Kwon EB, Jeong HR, Shim YS, Lee HS, Hwang JS

Multiple endocrine neoplasia (MEN) mutation is an autosomal dominant disorder characterized by the occurrence of parathyroid, pancreatic islet, and anterior pituitary tumors. The incidence of insulinoma in MEN is relatively...
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A Novel Germline Mutation of MEN1 Gene in a Young-aged Multiple Insulinoma with Hyperparathyroidism

Park YJ

Multiple endocrine neoplasia type 1 is an autosomal dominant disease caused by the MEN1 germline mutation. A 25-year-old male was admitted for loss of consciousness. Initial laboratory data showed hypoglycemia...
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Glucagon-Like Peptide-1 Increases Mitochondrial Biogenesis and Function in INS-1 Rat Insulinoma Cells

Kang MY, Oh TJ, Cho YM

Glucagon-like peptide-1 (GLP-1) is a gut-derived incretin hormone that increases glucose-stimulated insulin secretion in pancreatic beta-cells. Since mitochondrial function is crucial to insulin secretion, we hypothesized that GLP-1 may increase...
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Giant malignant insulinoma

Karavias D, Habeos I, Maroulis I, Kalogeropoulou C, Tsamandas , Chaveles I, Karavias D

Insulinomas are the most common pancreatic neuroendocrine tumors. Most insulinomas are benign, small, intrapancreatic solid tumors and only large tumors have a tendency for malignancy. Most patients present with symptoms...
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Clinical Features and Causes of Endogenous Hyperinsulinemic Hypoglycemia in Korea

Woo CY, Jeong JY, Jang JE, Leem J, Jung CH, Koh EH, Lee WJ, Kim MS, Park JY, Lee JB, Lee KU

BACKGROUND: Endogenous hyperinsulinemic hypoglycemia (EHH) is characterized by an inappropriately high plasma insulin level, despite a low plasma glucose level. Most of the EHH cases are caused by insulinoma, whereas...
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Endoscopic Ultrasonography-Guided Ethanol Ablation for Small Pancreatic Neuroendocrine Tumors: Results of a Pilot Study

Park DH, Choi JH, Oh D, Lee SS, Seo DW, Lee SK, Kim MH

BACKGROUND/AIMS: Endoscopic ultrasonography (EUS)-guided ethanol ablation is gaining popularity for the treatment of focal pancreatic lesions. The aim of this study was to evaluate the safety, feasibility, and treatment response...
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Development of multifocal nodular lesions of a liver mimicking hepatic metastasis, following resection of an insulinoma in a child

Jung SY, Kang B, Choi YM, Kim JM, Kim SK, Kwon YS, Lee JE

Insulinoma, which arises from insulin-producing pancreatic beta cells, is a rare tumor in children. Only 5%-10% of insulinomas are malignant and undergo metastasis. We report a case of an 11-year-old...
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An insulinoma with an aberrant feeder from the splenic artery detected by super-selective arterial calcium stimulation with venous sampling

Moon JH, Kim EK, Khang AR, Kim HC, Jang JY, Cho YM

No abstract available.
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A Case of Insulinoma Presenting as Repetitive Abnormal Behavior with Amnesia

Sohn SW, Yoon BA, Lee HJ, Shim DH, Park KW

Insulinomas are very rare tumors. Diagnosis of insulinoma is often delayed or misdiagnosed because of its various symptoms. We report a patient with hypoglycemic encephalopathy who had repetitive behavior changes,...
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Clinical Implications of Various Criteria for the Biochemical Diagnosis of Insulinoma

Ahn CH, Kim LK, Lee JE, Jung CH, Min SH, Park KS, Kim SY, Cho YM

BACKGROUND: Among the various diagnostic criteria for insulinoma, the ratio criteria have been controversial. However, the amended insulin-glucose ratio exhibited excellent diagnostic performance in a recent retrospective cohort study, although...
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Transformation of Nonfunctioning Pancreatic Neuroendocrine Carcinoma Cells into Insulin Producing Cells after Treatment with Sunitinib

Ohn JH, Kim YG, Lee SH, Jung HS

We report a rare case of severe hypoglycemia after sunitinib treatment for pancreatic neuroendocrine carcinoma. We describe the initial clinical presentation, laboratory results, pathologic findings, and managment in a patient...
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Red Liriope platyphylla stimulated the insulin secretion through the regulation of calcium concentration in rat insulinoma cells and animal models

Lee HR, Kim JE, Lee YJ, Kwak MH, Im DS, Hwang DY

The aim of this study was to investigate the effects of Red L. platyphylla (RLP) on calcium and glucose levels during insulin secretion. To achieve this, alteration of insulin and...
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