Korean J Urol.  2007 Mar;48(3):315-320. 10.4111/kju.2007.48.3.315.

The Suppressive Effect of Lentinus Edodes on Renal Scarring Secondary to Pyelonephritis

  • 1Department of Urology, Daegu Catholic University College of Medicine, Daegu, Korea. jspark@cu.ac.kr
  • 2Department of Pathology, Daegu Catholic University College of Medicine, Daegu, Korea.
  • 3Department of Microbiology, Daegu Catholic University College of Medicine, Daegu, Korea.
  • 4Department of Biomedical Statistics, Daegu Catholic University College of Medicine, Daegu, Korea.


Lentinus edodes is used in both foods and drugs, and is also known to be an antioxidant agent. Some investigators have noted that renal scarring following pyelonephritis is closely related to inflammation or free oxygen radicals, rather than to direct injury due to bacterial infection. The efficiency of the antioxidant agent, lentinus edodes, in preventing the renal scarring caused by experimental pyelonephritis was evaluated in rats.
Twenty eight male Sprague Dawley rats (n=28) were injected into both renal parenchyma with 0.1ml of a solution containing Escherichia coli (10(8)/ml). The control group, consisting of 4 rats, received an injection of isotonic saline instead of the bacterial solution. Three days after surgery, the animals were given the following treatments: in the pyelonephritis group, 7 rats received isotonic saline for 5 days; in the antibiotics treatment group, 6 rats were treated with an antibiotic only, ciprofloxacin, for 5 days. In the lentinus edodes treatment group, 5 rats were treated with lentinus edodes only. In the combined group, 6 rats received both lentinus edodes and ciprofloxacin. The kidneys were harvested 6 weeks after infection, and histopathologically examined for renal scarring.
Delayed treatment with antibiotics-only or lentinus edodes-only had no effect on the scarring compared with the untreated controls. However, the addition of lentinus edodes to the delayed antibiotic therapy significantly inhibited the renal scarring compared with the pyelonephritis, antibiotic-only treated and the lentinus edodes-only treated groups (p<0.05).
The administration of lentinus edodes in combination with antibiotics significantly reduced the renal scar formation in pyelonephritis.


Lentinus edodes; Pyelonephritis

MeSH Terms

Anti-Bacterial Agents
Bacterial Infections
Escherichia coli
Rats, Sprague-Dawley
Reactive Oxygen Species
Research Personnel
Shiitake Mushrooms*
Anti-Bacterial Agents
Reactive Oxygen Species


  • Fig. 1. Histological findings of the renal parenchyme 6 weeks after inoculation with E. coli. The control group (A) and the pyelonephritis group (B). Extensive infiltration of inflammatory cells into the tubule and interstitium can be seen. The antibiotics treatment group (C) and Lentinus edodes treatment group (D). The inflammation is less severe than in the pyelonephritis group. The combined treatment group (E). The renal inflammation has improved after the combination treatment of antibiotics and Lentinus edodes (H&E stain, x100).


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