Korean J Gastrointest Endosc.  1998 Oct;18(5):707-712.

Reflux Esophagitis after Cure of Helicobacter pylori Infection: Report of two cases

  • 1Department of Internal Medicine, Hallym University, College of Medicine, Seoul, Korea.


Helicobacter pylori infection causes chronic gastritis and its well documented con- sequences are peptic ulcer disease and gastric neoplasia. As duodenal ulcer is often associated with gastroesophageal reflux disease and antral gastritis is a frequent finding in patients with reflux disease, H. pylori infection may be a common cause of both conditions. Recent studies reveal that H. pylori has no role in the pathogenesis of reflux esophagitis. Furthermore, there are some arguments on whether H. pylori infection may have a protective role in reflux esophagitis. We have experienced two cases of reflux esophagitis after cure of H. pylori infection. H. pylori eradication therapy was performed in two patients who have gastric and/or duodenal ulcer with omeprazole and two anti-biotics (clarithromycin and amoxicillin). After cure of H. pylori infection, reflux esophagitis was demonstrated in these patients by endoscopy.


Helicobacter pylori; Reflux esophagitis; Gastric ulcer; Duodenal ulcer
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