J Dig Cancer Res.  2022 Dec;10(2):49-55. 10.52927/jdcr.2022.10.2.49.

Helicobacter pylori and Gastroesophageal Reflux Disease

  • 1Division of Gastroenterology, Department of Internal Medicine, Nowon Eulji Medical Center, Eulji University, Seoul, Korea


Helicobacter pylori (H. pylori) infection is associated with gastroduodenal diseases such as gastritis, peptic ulcer diseases, gastric adenocarcinoma, and mucosa-associated lymphoid tissue lymphoma. Furthermore, various extragastroduodenal diseases have been suggested to be related with H. pylori infection. Although no single factor has been considered the cause of gastroesophageal reflux disease (GERD), a negative association was found between the prevalence of H. pylori and GERD severity. Additionally, the role of eradication therapy of H. pylori in reflux esophagitis is controversial, and a significant correlation was found between successful H. pylori eradication rate and reflux esophagitis development. H. pylori infection remains an inconclusive and important issue in GERD. Thus, more experimental studies are necessary to elucidate the potential mechanisms.


Helicobacter pylori; Reflux esophagitis
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