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Efficacy of Seven-Day Potassium-Competitive Acid Blocker-Based First-Line Helicobacter pylori Eradication Therapy Administered with Bismuth

Kim JY, Lee SY, Kim H, Kim JH, Sung IK, Park HS

Purpose: To determine the efficacy of a potassium-competitive acid blocker (P-CAB)-based first-line eradication therapy with bismuth compared with that of proton pump inhibitor-based first-line therapy with bismuth. Materials and Methods: Eradication-naive...
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Evidence based guidelines for the treatment of Helicobacter pylori infection in Korea 2020

Jung HK, Kang SJ, Lee YC, Yang HJ, Park SY, Shin CM, Kim SE, Lim HC, Kim JH, Nam SY, Shin WG, Park JM, Choi IJ, Kim JG, Choi M, Korean College of Helicobacter and Upper Gastrointesinal Research

Helicobacter pylori infection is one of the most common infectious diseases worldwide. H. pylori is responsible for substantial gastrointestinal morbidity with a high disease burden. Since the revision of the...
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Interruption of Helicobacter pylori-Induced NLRP3 Inflammasome Activation by Chalcone Derivatives

Choi HR, Lim H, Lee JH, Park H, Kim HP

Helicobacter pylori causes chronic gastritis through cag pathogenicity island (cagPAI), vacuolating cytotoxin A (VacA), lipopolysaccharides (LPS), and flagellin as pathogen-related molecular patterns (PAMPs), which, in combination with the pattern recognition...
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Types of 23S Ribosomal RNA Point Mutations and Therapeutic Outcomes for Helicobacter pylori

Kim SY, Park JM, Lim CH, Lee HA, Shin GY, Choe Y, Cho YK, Choi MG

Background/Aims: Point mutations in the 23S ribosomal RNA gene have been associated with Helicobacter pylori clarithromycin resistance. This study aimed to detect the prevalence of these point mutations and to...
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Helicobacter pylori-derived outer membrane vesicles stimulate interleukin 8 secretion through nuclear factor kappa B activation

Choi MS, Ze EY, Park JY, Shin TS, Kim JG

Background/Aims: Bacteria-derived outer membrane vesicles (OMVs) are commonly associated with various biological activities and functions. Helicobacter pylori-derived OMVs are thought to contribute to pathogenesis. This study aimed to investigate the...
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A Nationwide Cohort Study Shows a Sex-Dependent Change in the Trend of Peptic Ulcer Bleeding Incidence in Korea between 2006 and 2015

Kim YS, Lee J, Shin A, Lee JM, Park JH, Jung HY

Background/Aims: The incidence of peptic ulcer disease has decreased in past decades; however, the trends in peptic ulcer bleeding (PUB) are inconsistent among regions. This study aimed to investigate the...
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Protective Effects of Silibinin on Helicobacter pyloriinduced Gastritis: NF-κB and STAT3 as Potential Targets

Cho K, Lee HG, Piao JY, Kim SJ, Na HK, Surh YJ

More than half of the world’s populations are considered to be infected by Helicobacter pylori. It causes a chronic inflammation of the stomach, which is implicated in the pathogenesis of...
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Evidence-Based Guidelines for the Treatment of Helicobacter pylori Infection in Korea: 2020 Revised Edition

Jung HK, Kang SJ, Lee YC, Yang HJ, Park SY, Shin CM, Kim SE, Lim HC, Kim JH, Nam SY, Shin WG, Park JM, Choi IJ, Kim JG, Choi M, Korean College of Helicobacter and Upper Gastrointesinal Research

Helicobacter pylori (H. pylori) infection is one of the most common infectious diseases worldwide. Although its incidence is gradually decreasing, about half of the world's population still get infected. H....
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Effect of Helicobacter pylori treatment on the long-term mortality in patients with type 2 diabetes

Kim YI, Kim YA, Kim HJ, Kim SH, Hwangbo Y, Kim JG, Kim JJ, Choi IJ

Background/Aims: Meta-analyses of randomized trials reported a non-significant increase in overall mortality risk after Helicobacter pylori eradication. In this study, we investigated whether H. pylori treatment is associated with increased...
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Characteristics and Early Diagnosis of Gastric Cancer Discovered after Helicobacter pylori Eradication

Ito M, Tanaka S, Chayama K

The prevalence of gastric cancer after eradication (GCAE) is increasing dramatically in Japan. GCAE has characteristic features, and we must understand these features in endoscopic examinations. Differentiated cancer types were...
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A comparative study of the prevalence of Helicobacter pylori in the oral biofilms of a group of dental and nondental undergraduates from Sri Lanka

Mallikaarachchi M, Rajapakse S, Gunawardhana K, Jayatilake J

Dental health care workers (DHCW) are at a risk of occupational exposure to Helicobacter pylori from the aerosolized oral biofilms and saliva of patients. We designed this study to investigate...
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Effect of Helicobacter Pylori eradication on patients with ITP: a meta-analysis of studies conducted in the Middle East

Sadegh Pezeshki SM, Saki N, Ghandali MV, Ekrami A, Avarvand AY

Background: Immune thrombocytopenia (ITP) is a bleeding disorder. Helicobacter Pylori is a Gram-negative bacterium that is presumed to be associated with ITP and therapeutic response of patients. To evaluate the...
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Evidence-Based Guidelines for the Treatment of Helicobacter pylori Infection in Korea 2020

Jung HK, Kang SJ, Lee YC, Yang HJ, Park SY, Shin CM, Kim SE, Lim HC, Kim JH, Nam SY, Shin WG, Park JM, Choi IJ, Kim JG, Choi M, Korean College of Helicobacter and Upper Gastrointestinal Research

Helicobacter pylori infection is one of the most common infectious diseases worldwide. Although the prevalence of H. pylori is gradually decreasing, approximately half of the world's population still becomes infected...
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The Current Strategy of Helicobacter pylori Eradication

Kwon YH

Helicobacter pylori (H. pylori) is the main cause of most gastroduodenal diseases. Triple therapy including two antibiotics, amoxicillin and clarithromycin, and a proton pump inhibitor given for a week has...
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Efficacy of Tegoprazan for Improving the Susceptibility of Antimicrobial Agents against Antibiotic-Resistant Helicobacter pylori

Lee JW, Kim N, Nam RH, Yu JE, Son JH, Lee SM, Lee DH

Background/Aims: Favorable outcomes of potassium-competitive acid blocker (PCAB)-containing eradication therapy have been reported. In fact, tegoprazan, a recently developed PCAB, was presumed to show good eradication efficacy even for resistant...
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Helicobacter pylori Treatment Strategies in Singapore

Ang TL, Ang D

The management of Helicobacter pylori infection in Singapore remains a clinical challenge. Similar to other regions, there has been an increase in antibiotic resistance rates through the years. Nonetheless, over...
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Synergistic effect of probiotic HP7 and the extracts of Perilla frutescens and Glycyrrhiza glabra to alleviate Helicobacter pylori-induced damages

Lee HA, Kim O

The efficacy of standard therapeutic strategies for Helicobacter pylori infection is decreasing over time due to the emergence of drug-resistant strains. At the our previous study, we reported that the...
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Efficacy of Seven-day High-dose Esomeprazole-based Triple Therapy versus Seven-day Standard Dose Non-esomeprazole-based Triple Therapy as the First-line Treatment of Patients with Helicobacter pylori Infection

Lee YD, Kim SE, Park SJ, Park MI, Moon W, Kim JH, Jung K, Song J

Background/Aims: The rates of Helicobacter pylori (H. pylori) eradication have declined with the use of proton pump inhibitor-amoxicillin-clarithromycin as the first-line triple therapy. On the other hand, several studies have...
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Impact of previous metronidazole exposure on metronidazole-based second-line quadruple therapy for Helicobacter pylori infection

Lee GH, Lee KM, Shin SJ, Kang JK, Noh CK, Kim JH, Lim SG

Background/Aims: The negative effects on the eradication success of Helicobacter pylori infection after previous exposure to macrolides, including clarithromycin on clarithromycin-based first-line therapy have been demonstrated. However,whether this is...
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Helicobacter pylori Eradication Can Reverse the Methylation-Associated Regulation of miR-200a/b in Gastric Carcinogenesis

Choi JM, Kim SG, Yang HJ, Lim JH, Cho NY, Kim WH, Kim JS, Jung HC

Background/Aims: Epigenetic change is one of the mecha- nisms that regulates the expression of microRNAs (miRNAs) and is known to play a role in Helicobacter pylori-associated gastric carcinogenesis. We aimed to...
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