Korean J Med.
2003 Sep;65(3):315-322.
Factors associated with bone mineral density in Korean middle-aged men
- Affiliations
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- 1Department of Internal Medicine, College of Medicine, Hallym University, Chunchon, Korea. okwendo@yahoo.co.kr
- 2Department of Radiology, College of Medicine, Hallym University, Chunchon, Korea.
- 3Department of Internal Medicine, Clinical Pathology, Miz Medi Hospital, Seoul, Korea.
- 4Department of Internal Medicine, Sungkyunkwan University School of Medicine, Seoul, Korea.
- 5Department of Internal Medicine, The Catholic University of Korea College of Medicine, Seoul, Korea.
Abstract
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BACKGROUND: Osteoporosis is a growing health problem not only in women but also in men. This cross-sectional study examined the association of anthropometric, lifestyle and hormonal factors with bone mineral density (BMD) in 152 healthy Korean middle-aged men.
METHODS
Smoking habits and alcohol consumption were assessed from an interview. Serum testosterone, growth hormone (GH) and insulin-like growth factor-1 (IGF-1) levels were measured by radioimmunoassay. GH stimulating tests were performed with ingestion of 500 mg of L-dopa. BMD was measured at the lumbar spine and femur neck using dual-energy X-ray absorptiometry.
RESULTS
3.9% of middle-aged men were osteoporotic and 28.3% were osteopenic at lumbar spine site, and 5.9% were osteoporotic and 45.4% were osteopenic at femur neck site. Lumbar spine BMD correlated significantly with body mass index (BMI, r=0.301, p<0.001). Femur neck BMD correlated significantly with BMI (r=0.314, p<0.001), age (r=-0.209, p<0.01) and serum IGF-1 level (r=0.267, p<0.01). Osteoporotic men at Lumbar spine BMD had significant difference in BMI and smoking habits (83.3% vs. 29.1%, p<0.05) than normal BMD. Also, osteoporotic men of femur neck BMD had significant difference in age, BMI and serum IGF-1 levels (192.9 g/L vs. 268.4 g/L, p<0.01).
CONCLUSION
Overall, 32.2~51.3% were osteopenic in Korean middle-aged men. We suggest that higher age, lower BMI, smoking habits and lower serum IGF-1 levels are risk factors for lower BMD in men. But, Serum testosterone and GH were not correlated with BMD in men.
MeSH Terms
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Absorptiometry, Photon
Alcohol Drinking
Body Mass Index
Bone Density*
Cross-Sectional Studies
Eating
Female
Femur Neck
Growth Hormone
Humans
Insulin-Like Growth Factor I
Levodopa
Life Style
Male
Osteoporosis
Radioimmunoassay
Risk Factors
Smoke
Smoking
Spine
Testosterone
Growth Hormone
Insulin-Like Growth Factor I
Levodopa
Smoke
Testosterone
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