Korean Circ J.  2013 Feb;43(2):87-92. 10.4070/kcj.2013.43.2.87.

The Prognostic Implication of Metabolic Syndrome in Patients with Heart Failure

• Yoon HJ
• Ahn Y
• Kim KH
• Park JC
• Choi DJ
• Han S
• Jeon ES
• Cho MC
• Kim JJ
• Yoo BS
• Shin MS
• Seong IW
• Kang SM
• Kim YJ
• Kim HS
• Chae SC
• Oh BH
• Lee MM
• Ryu KH
• The Korea HF Registry

• KMID: 1769643
• DOI: http://doi.org/10.4070/kcj.2013.43.2.87

Abstract

BACKGROUND AND OBJECTIVES
Metabolic syndrome (MetS) increases the risk of heart failure (HF). The purpose of this study was to identify the prevalence of MetS in patients with HF and determine the syndrome's association with HF in clinical and laboratory parameters.
SUBJECTS AND METHODS
A total of 3200 HF patients (67.6+/-14.5 years) enrolled in a nationwide prospective Korea HF Registry between Jan. 2005 and Oct. 2009. Patients were divided into two groups according to the presence or absence of MetS at admission: group I (presence, n=1141) and group II (absence, n=2059).
RESULTS
The prevalence of MetS was 35.7% across all subjects and was higher in females (56.0%). The levels of white blood cells, platelets, creatinine, glucose, and cholesterol were significantly higher in group I than in group II. Left ventricular dimension and volume was smaller and ejection fraction was higher in group I than in group II. An ischemic cause of HF was more frequent in group I. The rates of valvular and idiopathic cause were lower in group I than in group II. The rate of mortality was lower in group I than in group II (4.9% vs. 8.3%, p<0.001).
CONCLUSION
Despite the increased cardiovascular risks in MetS, MetS was found to be associated with decreased mortality in HF.

Keyword

Metabolic syndrome; Heart failure

MeSH Terms

Blood Platelets
Cholesterol
Creatinine
Female
Glucose
Heart
Heart Failure
Humans
Korea
Leukocytes
Prevalence
Prospective Studies
Cholesterol
Creatinine
Glucose

Figure

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  Fig. 1 Incidence of heart failure according to the etiology and ejection fraction. A: the etiology of heart failure between the two groups. B: the percent of systolic heart failure and heart failure with preserved systolic function (HFPSF). Group I: patients with metabolic syndrome, Group II: patients without metabolic syndrome. IHD: ischemic heart disease, HF: heart failure.

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  Fig. 2 Kaplan-Meier survival curve for two groups associatd with patient survival and adverse events. A: survival curve in patients with heart failure. B: in hospital and mid-term adverse events in patients with heart failure. Group I: patients with metabolic syndrome, Group II: patients without metabolic syndrome.

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