The effect of sex on drug consumption and recovery time in Entropy-monitored propofol-remifentanil anesthesia

Oh, Ji Na; Chung, Chan Jong; Lee, Ji Yeon; Park, Sang Won; Shin, Ho Jin; Lee, Jong Hwan

Abstract

BACKGROUND
It has been shown sex-related differences for propofol consumption and recovery time in general anesthesia. Recently, Entropy has been promoted as a monitor for anesthetic depth. This study investigated the effects of sex on drug consumption and recovery time in Entropy-monitored propofol-remifentanil anesthesia.
METHODS
Sixty-eight females and sixty-eight males, ASA physical status class 1 or 2, who were scheduled to undergo elective laparoscopic cholecystectomy were included. Anesthesia was induced and maintained with target-controlled infusion of propofol and remifentanil. Effect-site concentration (Ce) of propofol and remifentanil were adjusted according to the state entropy (SE) and hemodynamic parameters, respectively. Heart rate, blood pressure, response entropy (RE), SE, Ce of propofol, and Ce of remifentanil were measured during anesthesia. The time from stop of propofol until eye opening was compared between the females and males.
RESULTS
No significant differences existed between the females and males with respect to age, body mass index, duration of surgery, and duration of drug infusion. There were no significant differences between the females and males in the changes of blood pressure, heart rate, RE, SE, and Ce of propofol and remifentanil during anesthesia. Remifentanil consumption was similar between the females and males. Significantly higher amount of propofol was consumed in the females compared to the males (0.170 +/- 0.028 vs. 0.159 +/- 0.026 mg/kg/min, P < 0.05). The females woke significantly faster than the males (9.2 +/- 2.8 vs. 11.5 +/- 3.3 min, P < 0.05).
CONCLUSIONS
With Entropy guidance, mean propofol consumption and recovery time were sex-dependent in propofol-remifentanil anesthesia.