Int J Oral Biol.  2014 Jun;39(2):75-79.

Antimicrobial Effects of Oleanolic Acid, Ursolic Acid, and Sophoraflavanone G against Enterococcus faecalis and Propionibacterium acnes

Affiliations
  • 1Korean Collection for Oral Microbiology and Department of Oral Biochemistry, School of Dentistry, Chosun University, Gwangju, Korea. jkkook@chosun.ac.kr, jkkook@chosun.ac.kr
  • 2Department of Dental Hygiene, Chunnam Techno University, Chunnam, Korea.

Abstract

The aim of this study was to investigate antimicrobial effect of oleanolic acid (OA), ursolic acid (UA), and sophoraflavanone G against Enterococcus faecalis and Propionibacterium acnes, which are the major causative bacteria of endodontic infections. The antimicrobial activity was evaluated by the minimal inhibitory concentration (MIC). The data showed that the OA, UA, and sophoraflavanone G had antimicrobial effect on all the strains use in the study with 16-64 microg/ml, 8-64 microg/ml, and 1-8 microg/ml of MIC values, respectively. These results indicate that OA, UA, and sophoraflavanone G could be useful in the development of antiseptic solution for washing the root canal in endodontic treatments.

Keyword

antimicrobial effect; oleanolic acid; ursolic acid; sophoraflavanone G; Enterococcus faecalis; Propionibacterium acnes

MeSH Terms

Bacteria
Dental Pulp Cavity
Enterococcus faecalis*
Oleanolic Acid*
Propionibacterium acnes*
Oleanolic Acid
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