J Korean Med Sci.  2000 Aug;15(4):431-435. 10.3346/jkms.2000.15.4.431.

Association of the ACE gene polymorphism with the progression of autosomal dominant polycystic kidney disease

• Lee KB
• Kim UK
• Lee CC

• KMID: 1730640
• DOI: http://doi.org/10.3346/jkms.2000.15.4.431

Abstract

Renin-angiotensin system is considered important in the genesis of hypertension and development of end-stage renal disease (ESRD) in autosomal dominant polycystic kidney disease (ADPKD). The angiotensin converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism has been associated with susceptibility to the development of some renal diseases. We investigated the association of ACE gene polymorphism with the progression to hypertension and ESRD in 108 patients with ADPKD. The ACE I/D polymorphism was amplified with the flanking primers by polymerase chain reaction. In patients genotyped for ACE gene polymorphism, the frequencies of DD (15+ACU-), ID (51+ACU-) and II (34+ACU-) genotypes were similar to those of the general population. Of the 108 patients, 64 (59+ACU-) developed hypertension and 24 (22+ACU-) reached ESRD at the time of study. The prevalence of hypertension was not significantly different among the three genotypes. The mean renal survival time was 53-6 yr in II genotype, 5510 yr in ID genotype and 529 yr in DD genotype which was not significantly different among them. Cumulative renal survival was not significantly different either. There was no association of ACE gene polymorphism with the prevalence of hypertension and renal survival in ADPKD. We suggest that ACE I/D polymorphism is not an important modifying gene in the progression of ADPKD.

Keyword

Kidney, Polycystic, Autosomal Dominant; Peptidyl Dipeptidase A; Polymorphism(Genetics); Kidney Failure; Hypertension

MeSH Terms

Adult
Aged
Comparative Study
Disease Progression
Female
Genetic Predisposition to Disease
Genotype
Human
Hypertension, Renal/etiology
Hypertension, Renal/epidemiology
Kidney Failure, Chronic/etiology
Kidney Failure, Chronic/epidemiology
Korea/epidemiology
Male
Middle Age
Peptidyl-Dipeptidase A/genetics+ACo-
Polycystic Kidney, Autosomal Dominant/genetics+ACo-
Polycystic Kidney, Autosomal Dominant/epidemiology
Polycystic Kidney, Autosomal Dominant/enzymology
Polycystic Kidney, Autosomal Dominant/complications
Polymerase Chain Reaction
Polymorphism (Genetics)+ACo-
Prevalence