Ewha Med J.  2013 Dec;36(Suppl):S17-S21. 10.12771/emj.2013.36.S.S17.

Radiation Recall Dermatitis Induced by Gefitinib

Affiliations
  • 1Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea. hyosong77@yuhs.ac

Abstract

Radiation recall dermatitis refers to an acute inflammatory reaction in a previously irradiated field triggered by the administration of certain drugs days to years after the exposure to radiation. Gefitinib is an epidermal growth factor receptor tyrosine kinase inhibitor and is an effective treatment for patients with advanced stage of non small cell lung cancer (NSCLC). Here, we report a rare case of gefitinib induced radiation recall dermatitis. A 52-year-old woman with a metastatic NSCLC had received a palliative radiation therapy of 20 cGy on spine metastasis area (C6-T6). After 24 days of receiving radiation therapy, she had started to take gefitinib. Eight months after taking drug, pain, swelling and erythema of skin were occurred on previously irradiated field. These symptoms were resolved after the cessation of gefitinib for 6 days and the topical use of steroid.

Keyword

Gefitinib; Lung cancer; Radiation recall dermatitis; Radiation therapy

MeSH Terms

Erythema
Female
Humans
Lung Neoplasms
Middle Aged
Neoplasm Metastasis
Protein-Tyrosine Kinases
Radiodermatitis*
Receptor, Epidermal Growth Factor
Skin
Small Cell Lung Carcinoma
Spine
Protein-Tyrosine Kinases
Receptor, Epidermal Growth Factor

Figure

  • Fig. 1 (A) Erythema on upper back area (previously irradiated area). (B) Magnification of upper back area.

  • Fig. 2 Skin thickening and localized edema of lower cervical and upper thoracic area. There are no definite evidence of cellulitis (gadolinium enhanced T1 weighted sagittal magnetic resonance imaging).


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