Radiat Oncol J.
2023 Dec;41(4):292-296. 10.3857/roj.2023.00577.
A case of cetuximab-induced radiation recall skin dermatitis and review of the literature
- Affiliations
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- 1Department of Radiation Oncology, University of California San Francisco, San Francisco, CA, USA
- 2Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, TX, USA
- 3Division of Palliative Medicine, Department of Medicine, University of California San Francisco, San Francisco, CA, USA
- 4Division of Hematology and Oncology, Department of Medicine, University of California San Francisco, San Francisco, CA, USA
- 5Department of Urology, University of California San Francisco, San Francisco, CA, USA
- KMID: 2549378
- DOI: http://doi.org/10.3857/roj.2023.00577
Abstract
- Radiation recall presents as an acute inflammatory reaction triggered by systemic therapy, usually chemotherapy, and is typically limited to an area that was previously irradiated. Radiation recall reactions are generally self-limiting and most commonly occur in the skin. Many systemic agents have been described to elicit a radiation recall reaction, but the exact pathogenesis is largely unknown. Here, we describe the first reported case of radiation recall dermatitis following cetuximab. While cetuximab is associated with other skin reactions, oncologists should not exclude radiation recall dermatitis as a potential complication of cetuximab infusion in patients with prior radiation, and special attention should be paid to the pattern of skin changes both in terms of location and chronology.
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