Korean J Biol Psychiatry.
2006 Aug;13(3):137-143.
P50 and Schizophrenia
- Affiliations
-
- 1Department of Psychiatry, Ilsanpaik Hospital, Inje University of Korea, Goyang, Korea. lshpss@ilsanpaik.ac.kr
Abstract
- One of the most widely recognized neurophysiologic endophenotypes for schizophrenia is deficient gating or inhibition of the P50 component of the auditory event-related potential(ERP). A deficit in P50 sensory gating refers to a dysfunction in the mechanism responsible for modulating the brain's sensitivity of filtering out irrelevant or background stimuli, perhaps as a result of dysfunction in inhibitory neural circuits. In this paper, we review the neuronal and genetic aspects as well as medication effects on P50 in schizophrenia.
