J Vet Sci.  2010 Mar;11(1):35-41. 10.4142/jvs.2010.11.1.35.

Effect of German chamomile oil application on alleviating atopic dermatitis-like immune alterations in mice

Affiliations
  • 1Department of Beauty Art, Howon University, Gunsan 573-718, Korea.
  • 2Department of Occupational Health, Catholic University of Daegu, Gyeongsan 712-702, Korea.
  • 3Department of Public Health, Keimyung University, Daegu 704-701, Korea. yckim@kmu.ac.kr

Abstract

Historically, German chamomile (GC) oil has been used for treatment of skin disorders. BALB/c mice were sensitized twice a week with 100 microL of 1% 2,4-dinitrochlorobenzene (DNCB) and challenged twice the following week with 100 microliter of 0.2% DNCB for atopic dermatitis induction. Thereafter, 3% GC oil was applied daily (70 microliter, 6 times week) on the dorsal skin for 4 weeks. Saline or jojoba oil was used for the control mice. Blood was collected after second DNCB challenge, and at 2 and 4 weeks after initiating oil application. Serum IgE levels were significantly lowered in the GC oil application group at the end of the 4-week application period. The GC oil application for 4 weeks resulted in reduction in serum IgG1 level compared with that after 2-week application. The GC oil application group showed a significantly lower serum histamine level than the control group 2 weeks after oil application. Scratching frequency of the GC oil application group was significantly lower than either control groups. This study is to demonstrate GC oil's immunoregulatory potential for alleviating atopic dermatitis through influencing of Th2 cell activation.

Keyword

atopic dermatitis; cytokine; German chamomile oil; IgE; mice

MeSH Terms

Animals
Behavior, Animal/drug effects
Chamomile/*immunology
Dermatitis, Atopic/drug therapy/*immunology
Disease Models, Animal
Histamine/blood
Immunoglobulin E/blood
Immunoglobulin G/blood
Interleukin-4/analysis
Male
Matricaria/*immunology
Mice
Mice, Inbred BALB C
Phytotherapy/*methods
Specific Pathogen-Free Organisms
Th2 Cells/*immunology
Full Text Links
  • JVS
Actions
Cited
CITED
export Copy
Close
Share
  • Twitter
  • Facebook
Similar articles
    DB Error: unknown error