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Different Responses in Induction of Allergen Specific Immunoglobulin G4 and IgE-Blocking Factors for Three Mite Subcutaneous Immunotherapy Products

Park KH, Lee SC, Son YW, Jeong KY, Shin YS, Shin JU, Sim DW, Park HJ, Lee JH, Lee KH, Park JW

PURPOSE: Specific immunoglobulin G4 (sIgG4) and immunoglobulin E (IgE)-blocking factors produced by subcutaneous immunotherapy (SCIT) play a critical role in the induction of allergen tolerance. However, comparative studies of available...
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Cross-Reactivity between Oak and Birch Pollens in Korean Tree Pollinosis

Jeong KY, Son M, Park JH, Park KH, Park HJ, Lee JH, Hong CS, Park JW

Oak and birch trees belong to Fagales order. Specific IgE to pollen allergens of both trees are frequently found in Korea pollinosis patients. Oak trees which comprise 40% of forest...
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Standardization of Weed Pollen Extracts, Japanese Hop and Mugwort, in Korea

Jeong KY, Son M, Choi SY, Park KH, Park HJ, Hong CS, Lee JH, Park JW

PURPOSE: Japanese hop (Humulus spp.) and mugwort (Artemisia spp.) are notable causes of autumn pollinosis in East Asia. However, Japanese hop and mugwort pollen extracts, which are widely used for...
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Effects of Blending Oil of Lavender and Thyme on Oxidative Stress, Immunity, and Skin Condition in Atopic Dermatitis Induced Mice

Seo YM, Jeong SH

PURPOSE: The purpose of this study was to evaluate the effects of essential oil on oxidative stress, immunity, and skin condition in atopic dermatitis (AD) induced mice. METHODS: This study was...
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Serum Specific IgE to Thyroid Peroxidase Activates Basophils in Aspirin Intolerant Urticaria

Shin YS, Suh DH, Yang EM, Ye YM, Park HS

Thyroid antibodies are frequently observed in urticaria patients, but their roles in urticaria are not clearly elucidated. We investigated the role of serum specific IgE to thyroid peroxidase (TPO) in...
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Clinical features of elderly chronic urticaria

Ban GY, Kim MY, Yoo HS, Nahm DH, Ye YM, Shin YS, Park HS

BACKGROUND/AIMS: Chronic urticaria (CU) is defined as itchy wheals lasting 6 weeks or more. As the aged population increases worldwide, it is essential to identify the specific features of this...
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Association between Recent Acetaminophen Use and Asthma: Modification by Polymorphism at TLR4

Lee SH, Kang MJ, Yu HS, Hong K, Jung YH, Kim HY, Seo JH, Kwon JW, Kim BJ, Kim HJ, Kim YJ, Kim HS, Kim HB, Park KS, Lee SY, Hong SJ

The risk of asthma has been increasing in parallel with use of acetaminophen, which is a potential source of oxidative stress. Toll-like receptor 4 (TLR4) plays a critical role not...
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Increased Level of Basophil CD203c Expression Predicts Severe Chronic Urticaria

Ye YM, Yang EM, Yoo HS, Shin YS, Kim SH, Park HS

Increased FcepsilonR1alpha expression with upregulated CD203c expression on peripheral basophils is seen in patients with chronic urticaria (CU). However, there has been no published report on the association between CD203c...
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The Indoor Level of House Dust Mite Allergen Is Associated with Severity of Atopic Dermatitis in Children

Kim J, Lee S, Woo SY, Han Y, Lee JH, Lee IY, Lim IS, Choi ES, Choi BW, Cheong HK, Lee SI, Ahn K

We attempted to investigate the correlation between the severity of atopic dermatitis (AD) in children and the indoor level of house dust mite (HDM) allergens. Ninety-five patients (31.1 +/- 19.5...
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Identifying Genetic Susceptibility to Sensitization to Cephalosporins in Health Care Workers

Nam YH, Kim JE, Kim SH, Jin HJ, Hwang EK, Shin YS, Ye YM, Park HS

Exposure to cephalosporins could cause occupational allergic diseases in health care workers (HCWs). We evaluated the prevalence of serum specific IgE and IgG antibodies to cephalosporin-human serum albumin (HSA) conjugate...
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Downregulation of Orai1 expression in the airway alleviates murine allergic rhinitis

Wang Y, Lin L, Zheng C

Orai1 is the key subunit of the Ca2+-release-activated Ca2+ channel. Our previous report has demonstrated that Orai1 expression in the airway was upregulated in the ovalbumin (OVA)-induced allergic rhinitis (AR)...
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Exhaled Nitric Oxide is Associated with Allergic Inflammation in Children

Choi BS, Kim KW, Lee YJ, Baek J, Park HB, Kim YH, Sohn MH, Kim KE

Exhaled nitric oxide (eNO) has been proposed as a noninvasive marker of airway inflammation in asthma. In asthmatic patients, exhaled NO levels have been shown to relate with other markers...
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Natural Course of Cow's Milk Allergy in Children with Atopic Dermatitis

Suh J, Lee H, Lee JH, Cho J, Yu JS, Kim J, Han Y, Ahn K, Lee SI

Cow's milk is one of the most common food allergens in children with atopic dermatitis (AD). This study was conducted to describe the natural course of cow's milk allergy in...
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Protease-Activated Receptor 2 Is Involved in Th2 Responses against Trichinella spiralis Infection

Park MK, Cho MK, Kang SA, Park HK, Kim YS, Kim KU, Ahn SC, Kim DH, Yu HS

In order to get a better understanding of the role of protease-activated receptor 2 (PAR2) in type 2 helper T (Th2) cell responses against Trichinella spiralis infection, we analyzed Th2...
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Seroprevalence of Antibodies against Anisakis simplex Larvae among Health-Examined Residents in Three Hospitals of Southern Parts of Korea

Kim J, Jo JO, Choi SH, Cho MK, Yu HS, Cha HJ, Ock M

The present study was performed to estimate the seroprevalence of larval Anisakis simplex infection among the residents health-examined in 3 hospitals in southern parts of Korea. A total of 498...
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Therapeutic effects of recombinant Salmonella typhimurium harboring CCL22 miRNA on atopic dermatitis-like skin in mice

Yoon WS, Lee SS, Chae YS, Park YK

Th-2-biased immune responses are known to play a key role in the pathogenesis of atopic dermatitis. In particular, the macrophage-derived chemokine CCL22 is directly implicated in Th-2-associated skin inflammatory reactions,...
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Effect of German chamomile oil application on alleviating atopic dermatitis-like immune alterations in mice

Lee SH, Heo Y, Kim YC

Historically, German chamomile (GC) oil has been used for treatment of skin disorders. BALB/c mice were sensitized twice a week with 100 microL of 1% 2,4-dinitrochlorobenzene (DNCB) and challenged twice...
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Toxocariasis Might be an Important Cause of Atopic Myelitis in Korea

Lee JY, Kim BJ, Lee SP, Jeung YJ, Oh MJ, Park MS, Paeng JW, Lee BJ, Choi DC

Atopic myelitis is defined as myelitis with atopic diasthesis but the cause is still unknown. Toxocariasis is one of the common causes of hyperIgEaemia that may lead to neurologic manifestations....
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Impact of Toxocariasis in Patients with Unexplained Patchy Pulmonary Infiltrate in Korea

Yoon YS, Lee CH, Kang YA, Kwon SY, Yoon HI, Lee JH, Lee CT

Toxocariasis is one of the causes of pulmonary eosinophilic infiltrate that is increasing in Korea. This study was designed to identify the prevalence of toxocara seropositivity in patients with unexplained...
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Identification of Dioscorea Batatas (Sanyak) Allergen as an Inhalant and Oral Allergen

Hur GY, Park HJ, Kim HA, Ye YM, Park HS

Dioscorea batatas is widely used in Asia as a herbal medicine or food product with potential health benefits. There have been several reports of occupational asthma caused by inhalation of...
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