- Immune Tolerance of Human Dental Pulp-Derived Mesenchymal Stem Cells Mediated by CD4âºCD25âºFoxP3⺠Regulatory T-Cells and Induced by TGF-β1 and IL-10
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Hong JW, Lim JH, Chung CJ, Kang TJ, Kim TY, Kim YS, Roh TS, Lew DH
- KMID: 2418942
- Yonsei Med J.
- 2017 Sep;58(5):1031-1039.
- doi: 10.3349/ymj.2017.58.5.1031
PURPOSE: Most studies on immune tolerance of mesenchymal stem cells (MSCs) have been performed using MSCs derived from bone marrow, cord blood, or adipose tissue. MSCs also exist in the... -
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- Down-Regulation of TGF-β Expression Sensitizes the Resistance of Hepatocellular Carcinoma Cells to Sorafenib
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Kang D, Han Z, Oh GH, Joo Y, Choi HJ, Song JJ
- KMID: 2418924
- Yonsei Med J.
- 2017 Sep;58(5):899-909.
- doi: 10.3349/ymj.2017.58.5.899
PURPOSE: Sorafenib, a multikinase inhibitor, is the standard therapy for patients with advanced-stage hepatocellular carcinoma (HCC). However, resistance develops to the treatment, therefore, we tried to unravel the underlying mechanism... -
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- Bordetella bronchiseptica antigen enhances the production of Mycoplasma hyopneumoniae antigen-specific immunoglobulin G in mice
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Yim SH, Hahn TW, Joo HG
- KMID: 2412450
- J Vet Sci.
- 2017 Sep;18(3):327-332.
- doi: 10.4142/jvs.2017.18.3.327
We previously demonstrated that Bordetella (B.) bronchiseptica antigen (Ag) showed high immunostimulatory effects on mouse bone marrow cells (BMs) while Mycoplasma (M.) hyopneumoniae Ag showed low effects. The focus of... -
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- Effect of the fourth nucleotide at the 3′ end of neuraminidase and matrix viral genomic RNA on the pathogenicity of influenza virus A/PR/8/34
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Lee CY, Kwon HJ, Nguyen TT, Kim I, Jang HK, Kim JH
- KMID: 2412555
- J Vet Sci.
- 2017 Aug;18(S1):307-313.
- doi: 10.4142/jvs.2017.18.S1.307
Twelve nucleotides located at the 3′ end of viral genomic RNA (vRNA) are conserved among influenza A viruses (IAV) and have a promoter function. Hoffmann's 8-plasmid reverse genetics vector system... -
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- Optimized clade 2.3.2.1c H5N1 recombinant-vaccine strains against highly pathogenic avian influenza
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Jang JW, Lee CY, Kim IH, Choi JG, Lee YJ, Yuk SS, Lee JH, Song CS, Kim JH, Kwon HJ
- KMID: 2412554
- J Vet Sci.
- 2017 Aug;18(S1):299-306.
- doi: 10.4142/jvs.2017.18.S1.299
A/Puerto Rico/8/34 (PR8)-derived recombinant viruses have been used for seasonal flu vaccines; however, they are insufficient for vaccines against some human-fatal H5N1 highly pathogenic avian influenza (HPAI) viruses (HPAIV) due... -
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- Immunogenicity of recombinant Lactobacillus plantarum NC8 expressing goose parvovirus VP2 gene in BALB/c mice
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Liu YY, Yang WT, Shi SH, Li YJ, Zhao L, Shi CW, Zhou FY, Jiang YL, Hu JT, Gu W, Yang GL, Wang CF
- KMID: 2412568
- J Vet Sci.
- 2017 Jun;18(2):159-167.
- doi: 10.4142/jvs.2017.18.2.159
Goose parvovirus (GPV) continues to be a threat to goose farms and has significant economic effects on the production of geese. Current commercially available vaccines only rarely prevent GPV infection.... -
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- Effect of fermented soybean products intake on the overall immune safety and function in mice
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Lee JH, Paek SH, Shin HW, Lee SY, Moon BS, Park JE, Lim GD, Kim CY, Heo Y
- KMID: 2412584
- J Vet Sci.
- 2017 Mar;18(1):25-32.
- doi: 10.4142/jvs.2017.18.1.25
Various functional activities have been reported for the fermented soybean products doenjang (DJ) and cheonggukjang (CGJ), although no systemic investigations of their immune functions have been conducted to date. We... -
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- Paclitaxel inhibits the hyper-activation of spleen cells by lipopolysaccharide and induces cell death
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Kim HJ, Joo HG
- KMID: 2412600
- J Vet Sci.
- 2016 Dec;17(4):453-458.
- doi: 10.4142/jvs.2016.17.4.453
Paclitaxel was isolated from the bark of the Pacific yew, Taxus brevifolia, and used as an anticancer agent. Paclitaxel prevents cancer cell division by inhibiting spindle fiber function, inducing cell... -
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- Eukaryotic Translation Initiation Factor 3a (eIF3a) Promotes Cell Proliferation and Motility in Pancreatic Cancer
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Wang SQ, Liu Y, Yao MY, Jin J
- KMID: 2468249
- J Korean Med Sci.
- 2016 Oct;31(10):1586-1594.
- doi: 10.3346/jkms.2016.31.10.1586
Identifying a target molecule that is crucially involved in pancreatic tumor growth and metastasis is necessary in developing an effective treatment. The study aimed to investigate the role of the... -
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- Therapeutic Effects of Microbubbles Added to Combined High-Intensity Focused Ultrasound and Chemotherapy in a Pancreatic Cancer Xenograft Model
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Yu MH, Lee JY, Kim HR, Kim BR, Park EJ, Kim HS, Han JK, Choi BI
- KMID: 2458071
- Korean J Radiol.
- 2016 Oct;17(5):779-788.
- doi: 10.3348/kjr.2016.17.5.779
OBJECTIVE: To investigate whether high-intensity focused ultrasound (HIFU) combined with microbubbles enhances the therapeutic effects of chemotherapy. MATERIALS AND METHODS: A pancreatic cancer xenograft model was established using BALB/c nude mice... -
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- Renoprotective Effects of a Highly Selective A3 Adenosine Receptor Antagonist in a Mouse Model of Adriamycin-induced Nephropathy
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Min HS, Cha JJ, Kim K, Kim JE, Ghee JY, Kim H, Lee JE, Han JY, Jeong LS, Cha DR, Kang YS
- KMID: 2468272
- J Korean Med Sci.
- 2016 Sep;31(9):1403-1412.
- doi: 10.3346/jkms.2016.31.9.1403
The concentration of adenosine in the normal kidney increases markedly during renal hypoxia, ischemia, and inflammation. A recent study reported that an A3 adenosine receptor (A3AR) antagonist attenuated the progression... -
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- OTX1 Contributes to Hepatocellular Carcinoma Progression by Regulation of ERK/MAPK Pathway
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Li H, Miao Q, Xu CW, Huang JH, Zhou YF, Wu MJ
- KMID: 2373748
- J Korean Med Sci.
- 2016 Aug;31(8):1215-1223.
- doi: 10.3346/jkms.2016.31.8.1215
Orthodenticlehomeobox 1 (OTX1) overexpression had previously been associated with the progression of several tumors. The present study aimed to determine the expression and role of OTX1 in human hepatocellular carcinoma... -
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- Dual-Blocking of PI3K and mTOR Improves Chemotherapeutic Effects on SW620 Human Colorectal Cancer Stem Cells by Inducing Differentiation
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Kim MJ, Koo JE, Han GY, Kim B, Lee YS, Ahn C, Kim CW
- KMID: 2363495
- J Korean Med Sci.
- 2016 Mar;31(3):360-370.
- doi: 10.3346/jkms.2016.31.3.360
Cancer stem cells (CSCs) have tumor initiation, self-renewal, metastasis and chemo-resistance properties in various tumors including colorectal cancer. Targeting of CSCs may be essential to prevent relapse of tumors after... -
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- A novel M2e-multiple antigenic peptide providing heterologous protection in mice
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Wen F, Ma JH, Yu H, Yang FR, Huang M, Zhou YJ, Li ZJ, Wang XH, Li GX, Jiang YF, Tong W, Tong GZ
- KMID: 2363337
- J Vet Sci.
- 2016 Mar;17(1):71-78.
- doi: 10.4142/jvs.2016.17.1.71
Swine influenza viruses (SwIVs) cause considerable morbidity and mortality in domestic pigs, resulting in a significant economic burden. Moreover, pigs have been considered to be a possible mixing vessel in... -
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- Effect of intranasal rosiglitazone on airway inflammation and remodeling in a murine model of chronic asthma
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Lee HY, Rhee CK, Kang JY, Park CK, Lee SY, Kwon SS, Kim YK, Yoon HK
- KMID: 2373777
- Korean J Intern Med.
- 2016 Jan;31(1):89-97.
- doi: 10.3904/kjim.2016.31.1.89
BACKGROUND/AIMS: Asthma is characterized by airway hyperresponsiveness, inflammation, and remodeling. Peroxisome proliferator-activated receptors have been reported to regulate inflammatory responses in many cells. In this study, we examined the effects... -
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- Pathological Lesions and Inducible Nitric Oxide Synthase Expressions in the Liver of Mice Experimentally Infected with Clonorchis sinensis
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Yang QL, Shen JQ, Xue Y, Cheng XB, Jiang ZH, Yang YC, Chen YD, Zhou XN
- KMID: 2360163
- Korean J Parasitol.
- 2015 Dec;53(6):777-783.
- doi: 10.3347/kjp.2015.53.6.777
The nitric oxide (NO) formation and intrinsic nitrosation may be involved in the possible mechanisms of liver fluke-associated carcinogenesis. We still do not know much about the responses of inducible... -
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- Chronic Toxoplasmosis Modulates the Induction of Contact Hypersensitivity by TNCB in Mouse Model
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Yang Z, Ahn HJ, Nam HW
- KMID: 2360159
- Korean J Parasitol.
- 2015 Dec;53(6):755-757.
- doi: 10.3347/kjp.2015.53.6.755
Mouse models of chronic toxoplasmosis and atopic dermatitis (AD) were combined to clarify the effect of opportunistic Toxoplasma gondii infection on the development of AD. AD was induced as a... -
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- The Wnt/beta-catenin signaling pathway regulates the development of airway remodeling in patients with asthma
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Kwak HJ, Park DW, Seo JY, Moon JY, Kim TH, Sohn JW, Shin DH, Yoon HJ, Park SS, Kim SH
- KMID: 2359885
- Exp Mol Med.
- 2015 Dec;47(12):e198.
- doi: 10.1038/emm.2015.91
Airway remodeling is a key characteristic of chronic asthma, particularly in patients with a fixed airflow limitation. The mechanisms underlying airway remodeling are poorly understood, and no therapeutic option is... -
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- Murine Sca1+Lin- bone marrow contains an endodermal precursor population that differentiates into hepatocytes
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Oh K, Shon SY, Seo MW, Lee HM, Oh JE, Choi EY, Lee DS, Park KS
- KMID: 2160618
- Exp Mol Med.
- 2015 Oct;47(10):e187.
- doi: 10.1038/emm.2015.64
The direct differentiation of hepatocytes from bone marrow cells remains controversial. Several mechanisms, including transdifferentiation and cell fusion, have been proposed for this phenomenon, although direct visualization of the process... -
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- Quantitative determination of 12-hydroxyeicosatetraenoic acids by chiral liquid chromatography tandem mass spectrometry in a murine atopic dermatitis model
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Hong SH, Han JE, Ko JS, Do SH, Lee EH, Cho MH
- KMID: 2344303
- J Vet Sci.
- 2015 Sep;16(3):307-315.
- doi: 10.4142/jvs.2015.16.3.307
Atopic dermatitis, one of the most important skin diseases, is characterized by both skin barrier impairment and immunological abnormalities. Although several studies have demonstrated the significant relationship between atopic dermatitis... -
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