- Ubiquitination of Aquaporin: in the kidney
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Lee YJ, Kwon TH
- KMID: 1464781
- Electrolyte Blood Press.
- 2009 Jun;7(1):1-4.
- doi: 10.5049/EBP.2009.7.1.1
Ubiquitination is known to be important for endocytosis and lysosomal degradation of aquaporin-2 (AQP2). Ubiquitin (Ub) is covalently attached to the lysine residue of the substrate proteins and activation and... -
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- Modulating cellular balance of Rps3 mono-ubiquitination by both Hel2 E3 ligase and Ubp3 deubiquitinase regulates protein quality control
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Jung Y, Kim HD, Yang HW, Kim HJ, Jang CY, Kim J
- KMID: 2396795
- Exp Mol Med.
- 2017 Nov;49(11):e390.
- doi: 10.1038/emm.2017.128
When a ribosome complex is stalled during the translation elongation process in eukaryotes, the mono-ubiquitination of Rps3 has recently been shown to be critical to ribosome quality control. We have... -
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- Pja2 Inhibits Wnt/β-catenin Signaling by Reducing the Level of TCF/LEF1
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Song Y, Lee S, Kim JR, Jho EH
- KMID: 2429557
- Int J Stem Cells.
- 2018 Nov;11(2):242-247.
- doi: 10.15283/ijsc18032
Ubiquitination of proteins plays an essential role in various cellular processes, including protein degradation, DNA repair, and cell signaling pathways. Previous studies have shown that protein ubiquitination is implicated in... -
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- Herpesvirus-encoded Deubiquitinating Proteases and Their Roles in Regulating Immune Signaling Pathways
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Kwon KM, Ahn JH
- KMID: 1501992
- J Bacteriol Virol.
- 2013 Dec;43(4):244-252.
- doi: 10.4167/jbv.2013.43.4.244
Viruses interact with the host ubiquitination system in a variety of ways. Viral proteins are often a substrate for ubiquitination, which leads to proteasomal degradation. Viruses also have functions to... -
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- PIG3 Regulates p53 Stability by Suppressing Its MDM2-Mediated Ubiquitination
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Jin M, Park SJ, Kim SW, Kim HR, Hyun JW, Lee JH
- KMID: 2386906
- Biomol Ther.
- 2017 Jul;25(4):396-403.
- doi: 10.4062/biomolther.2017.086
Under normal, non-stressed conditions, intracellular p53 is continually ubiquitinated by MDM2 and targeted for degradation. However, in response to severe genotoxic stress, p53 protein levels are markedly increased and apoptotic... -
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- The Macrophage-Specific Transcription Factor Can Be Modified Posttranslationally by Ubiquitination in the Lipopolysaccharide-Treated Macrophages
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Jung JW, Choi JC, Kim JY, Park IW, Choi BW, Shin JW, Christman
- KMID: 1442860
- Tuberc Respir Dis.
- 2011 Feb;70(2):113-124.
- doi: 10.4046/trd.2011.70.2.113
BACKGROUND: Macrophages are one of the most important inflammatory cells in innate immunity. PU.1 is a macrophage-specific transcription factor. Ubiquitins are the ultimate regulator of eukaryotic transcription. The ubiquitination process... -
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- Regulation of Protein Degradation by Proteasomes in Cancer
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Jang HH
- KMID: 2447446
- J Cancer Prev.
- 2018 Dec;23(4):153-161.
- doi: 10.15430/JCP.2018.23.4.153
Imbalance of protein homeostasis (proteostasis) is known to cause cellular malfunction, cell death, and diseases. Elaborate regulation of protein synthesis and degradation is one of the important processes in maintaining... -
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- HIF-1alpha Upregulation due to Depletion of the Free Ubiquitin Pool
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Kim J, So D, Shin HW, Chun YS, Park JW
- KMID: 2344170
- J Korean Med Sci.
- 2015 Oct;30(10):1388-1395.
- doi: 10.3346/jkms.2015.30.10.1388
Hypoxia-inducible factor 1alpha (HIF-1alpha), which transactivates a variety of hypoxia-induced genes, is rapidly degraded under nomoxia through the hydroxylation-ubiquitination-proteasome pathway. In this study, we addressed how HIF-1alpha is stabilized by... -
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- STAT3 inhibits the degradation of HIF-1alpha by pVHL-mediated ubiquitination
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Jung JE, Kim HS, Lee CS, Shin YJ, Kim YN, Kang GH, Kim TY, Juhnn YS, Kim SJ, Park JW, Ye SK, Chung MH
- KMID: 1104801
- Exp Mol Med.
- 2008 Oct;40(5):479-485.
- doi: 10.3858/emm.2008.40.5.479
Hypoxia-inducible factor 1alpha (HIF-1alpha) is rapidly degraded by the ubiquitin-proteasome pathway under normoxic conditions. Ubiquitination of HIF-1alpha is mediated by interaction with von Hippel-Lindau tumor suppressor protein (pVHL). In our... -
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- F-box only protein 9 is an E3 ubiquitin ligase of PPARγ
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Lee KW, Kwak SH, Koo YD, Cho YK, Lee HM, Jung HS, Cho YM, Park YJ, Chung SS, Park KS
- KMID: 2361521
- Exp Mol Med.
- 2016 May;48(5):e234.
- doi: 10.1038/emm.2016.31
Peroxisome proliferator-activated receptor gamma (PPARγ) is a critical regulator of carbohydrate and lipid metabolism, adipocyte differentiation and inflammatory response. Post-translational modification of PPARγ and its degradation involve several pathways, including... -
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- Repeated electroconvulsive seizure induces c-Myc down-regulation and Bad inactivation in the rat frontal cortex
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Jeon WJ, Kim SH, Seo MS, Kim Y, Kang UG, Juhnn YS, Kim YS
- KMID: 1094123
- Exp Mol Med.
- 2008 Aug;40(4):435-444.
- doi: 10.3858/emm.2008.40.4.435
Repeated electroconvulsive seizure (ECS), a model for electroconvulsive therapy (ECT), exerts neuroprotective and proliferative effects in the brain. This trophic action of ECS requires inhibition of apoptotic activity, in addition... -
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- Transient exposure to hydrogen peroxide inhibits the ubiquitination of phosphorylated IkappaBalpha in TNFalpha-stimulated HEK293 cells
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Lee Y, Choi J, Ha KH, Jue DM
- KMID: 1387362
- Exp Mol Med.
- 2012 Aug;44(8):513-520.
During ischemia-reperfusion injury, brief pre-exposure to oxidative stress renders organs resistant to subsequent severe damage. NF-kappaB is a transcription factor that is involved in reperfusion-induced inflammatory and immune responses. The... -
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- Sumoylation of Hes6 Regulates Protein Degradation and Hes1-Mediated Transcription
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Lee J, Chun SK, Son GH, Kim K
- KMID: 2407090
- Endocrinol Metab.
- 2015 Sep;30(3):381-388.
- doi: 10.3803/EnM.2015.30.3.381
BACKGROUND: Hes6 is a transcriptional regulator that induces transcriptional activation by binding to transcription repressor Hes1 and suppressing its activity. Hes6 is controlled by the ubiquitin-proteosome-mediated degradation system. Here we... -
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- Laminar flow activation of ERK5 leads to cytoprotective effect via CHIP-mediated p53 ubiquitination in endothelial cells
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Lim JH, Woo CH
- KMID: 1447440
- Anat Cell Biol.
- 2011 Dec;44(4):265-273.
- doi: 10.5115/acb.2011.44.4.265
Atherosclerosis is readily observed in areas where disturbed flow is formed, while the atheroprotective region is found in areas with steady laminar flow (L-flow). It has been established that L-flow... -
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- Ubiquitin E3 Ligase Pellino-1 Inhibits IL-10-mediated M2c Polarization of Macrophages, Thereby Suppressing Tumor Growth
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Kim D, Koh J, Ko JS, Kim HY, Lee H, Chung DH
- KMID: 2461196
- Immune Netw.
- 2019 Oct;19(5):e32.
- doi: 10.4110/in.2019.19.e32
Pellino-1 is a ubiquitin (Ub) E3 ligase that plays a role in M1, but not M2a polarization of macrophages. However, it is unknown whether Pellino-1 regulates IL-10-mediated M2c polarization of... -
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- Proteolytic Regulation of Retinoblastoma Family Protein p107 by Ubiquitin - proteasome Pathway
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Jang JS, Park BK, Hwang SG
- KMID: 2175114
- J Korean Cancer Assoc.
- 2000 Apr;32(2):417-421.
PURPOSE: Proteolysis is an important way to regulate cell cycle regulatory proteins. Ubiquitin- proteasome pathway regards as highly selective proteolytic machinary mostly in physiological state. We investigated the role of ubiquitin-proteasome pathway... -
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- Nur77 upregulates HIF-alpha by inhibiting pVHL-mediated degradation
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Kim BY, Kim H, Cho EJ, Youn HD
- KMID: 1103590
- Exp Mol Med.
- 2008 Feb;40(1):71-83.
- doi: 10.3858/emm.2008.40.1.71
In this study, we investigated the role of Nur77, an orphan nuclear receptor, in HIF-alpha transcriptional activity. We found that Nur77 associates and stabilizes HIF-1alpha via indirect interaction. Nur77 was... -
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- The Role of Tripartite Motif Family Proteins in TGF-β Signaling Pathway and Cancer
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Lee HJ
- KMID: 2447447
- J Cancer Prev.
- 2018 Dec;23(4):162-169.
- doi: 10.15430/JCP.2018.23.4.162
TGF-β signaling plays a tumor suppressive role in normal and premalignant cells but promotes tumor progression during the late stages of tumor development. The TGF-β signaling pathway is tightly regulated... -
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- Influence of Polycomb Proteins and Epigenetic Transcriptional Modifiers on the Development and Activation of T Lymphocytes
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Chun T
- KMID: 2168218
- Hanyang Med Rev.
- 2013 Feb;33(1):33-38.
- doi: 10.7599/hmr.2013.33.1.33
Transcriptional regulation of a gene is not always correlated with genetic information inherited from parents because the transcription of specific genes is often governed by the modification of chromatin structure.... -
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- GLP-1 Can Protect Proinflammatory Cytokines Induced Beta Cell Apoptosis through the Ubiquitination
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Lim DM, Kim JY, Lee KW, Park KY, Kim BJ
- KMID: 1497721
- Endocrinol Metab.
- 2011 Jun;26(2):142-149.
- doi: 10.3803/EnM.2011.26.2.142
BACKGROUND: Proinflammatory cytokines are one of the causes of diabetes mellitus. However, the exact molecular mechanism by which proinflammatory cytokines induce beta-cell death remains to be clearly elucidated. Glucagon-like peptide-1... -
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