J Bacteriol Virol.  2013 Dec;43(4):244-252. 10.4167/jbv.2013.43.4.244.

Herpesvirus-encoded Deubiquitinating Proteases and Their Roles in Regulating Immune Signaling Pathways

• Kwon KM
• Ahn JH

• KMID: 1501992
• DOI: http://doi.org/10.4167/jbv.2013.43.4.244

Abstract

Viruses interact with the host ubiquitination system in a variety of ways. Viral proteins are often a substrate for ubiquitination, which leads to proteasomal degradation. Viruses also have functions to modify the cellular ubiquitination machinery. Recently, deubiquitinating protease (DUB) activity has been found in many viral proteins. In herpesviruses, the DUB domain is found within the large tegument protein, which is conserved in all members of the herpesvirus family. Although a limited number of viral and cellular targets have been identified to date, accumulating evidence shows that herpesviral DUBs may primarily target key cellular regulators of immune signaling pathways to promote viral replication. In this review, we summarize the recent findings on viral DUBs. In particular, we focus on the herpesviral DUBs and their targets, and discuss their potential roles in the regulation of immune signaling pathways.

Keyword

Ubiquitin; Deubiquitinating protease; Herpesvirus; Immune signaling

MeSH Terms

Herpesviridae
Humans
Peptide Hydrolases*
Ubiquitin
Ubiquitination
Viral Proteins
Peptide Hydrolases
Ubiquitin
Viral Proteins