Hanyang Med Rev.  2013 Feb;33(1):33-38. 10.7599/hmr.2013.33.1.33.

Influence of Polycomb Proteins and Epigenetic Transcriptional Modifiers on the Development and Activation of T Lymphocytes

• Chun T

• KMID: 2168218
• DOI: http://doi.org/10.7599/hmr.2013.33.1.33

Abstract

Transcriptional regulation of a gene is not always correlated with genetic information inherited from parents because the transcription of specific genes is often governed by the modification of chromatin structure. The study of transcriptional regulation by modifying chromatin structure is well-known as "epigenetics". Several methods involved in the modification of chromatin structure have been developed in the mammalian species during evolution. Among those methods, methylations of specific DNA region or histone are often used to control specific gene transcription. Therefore, understanding the activity of proteins involved in DNA or histone methylation is an initial step to control the transcriptional activity of a specific gene. Polycomb group (PcG) proteins were known to be repressors of transcription of a specific gene by creating and maintaining methylation or ubiquitination of the specific region of histone. Dependent on the target histone, the activity of PcG proteins effects on the development of specific lineage cells or the activity of specific cell types. In this review, the function, expression and activity of PcG proteins related with the development or activation of T cells are discussed.

Keyword

Chromatin; Epigenomics; Histone Code; Polycomb-Group Proteins; T-Lymphocytes

MeSH Terms

Chromatin
DNA
Epigenomics
Genes, vif
Histone Code
Histones
Humans
Methylation
Parents
Polycomb-Group Proteins
Proteins
T-Lymphocytes
Ubiquitin
Ubiquitination
Chromatin
DNA
Histones
Polycomb-Group Proteins
Proteins
Ubiquitin

Figure

• 

  Fig. 1 Transcriptional inhibition by polycomb proteins [10-17]. (A) Trimethylation of K27 residue on H3 histone by polycomb proteins blocks the transcription of target gene, (B) Ubiquitination of K119 residue on H2A histone by polycomb proteins blocks the transcription of target gene, (C) Either histone deacetylation or DNA methylation by polycomb proteins blocks the transcription of target gene.

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