- Network pharmacology and molecular docking reveal the mechanism of Qinghua Xiaoyong Formula in Crohn’s disease
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Fang C, Pei Y, Peng Y, Lu H, Qu Y, Luo C, Lu Y, Yang W
- KMID: 2544138
- Korean J Physiol Pharmacol.
- 2023 Jul;27(4):365-374.
- doi: 10.4196/kjpp.2023.27.4.365
Crohn's disease (CD) is a chronic inflammatory illness of the digestive system with unknown etiology, and its incidence is increasing worldwide. However, there are currently no effective treatments or medications... -
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- Experimental model and novel therapeutic targets for non-alcoholic fatty liver disease development
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Jin Y, Heo KS
- KMID: 2544132
- Korean J Physiol Pharmacol.
- 2023 Jul;27(4):299-310.
- doi: 10.4196/kjpp.2023.27.4.299
Non-alcoholic fatty liver disease (NAFLD) is a complex disorder characterized by the accumulation of fat in the liver in the absence of excessive alcohol consumption. It is one of the... -
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- Involvement of α1B -adrenoceptors and Rho kinase in contractions of rat aorta and mouse spleen
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Alsufyani HA, Docherty JR
- KMID: 2544134
- Korean J Physiol Pharmacol.
- 2023 Jul;27(4):325-331.
- doi: 10.4196/kjpp.2023.27.4.325
α 1 -adrenoceptors link via the G-protein Gq/G11 to both Ca2+ entry and release from stores, but may also activate Rho kinase, which causes calcium sensitization. This study aimed to... -
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- Roles of non-coding RNAs in intercellular crosstalk in cardiovascular diseases
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Lim YH, Kim YK
- KMID: 2544131
- Korean J Physiol Pharmacol.
- 2023 Jul;27(4):289-298.
- doi: 10.4196/kjpp.2023.27.4.289
Complex diseases including cardiovascular disease are caused by a combination of the alternation of many genes and the influence of environments. Recently, non-coding RNAs (ncRNAs) have been shown to be involved... -
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- Unveiling the impact of lysosomal ion channels: balancing ion signaling and disease pathogenesis
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Jung Y, Kim W, Shin NK, Bae YM, Wie J
- KMID: 2544133
- Korean J Physiol Pharmacol.
- 2023 Jul;27(4):311-323.
- doi: 10.4196/kjpp.2023.27.4.311
Ion homeostasis, which is regulated by ion channels, is crucial for intracellular signaling. These channels are involved in diverse signaling pathways, including cell proliferation, migration, and intracellular calcium dynamics. Consequently,... -
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- Encainide, a class Ic anti-arrhythmic agent, blocks voltage-dependent potassium channels in coronary artery smooth muscle cells
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Li H, Zhou Y, Yang Y, Zha Y, Ye B, Mun SY, Zhuang W, Liang J, Park WS
- KMID: 2544141
- Korean J Physiol Pharmacol.
- 2023 Jul;27(4):399-406.
- doi: 10.4196/kjpp.2023.27.4.399
Voltage-dependent K + (Kv) channels are widely expressed on vascular smooth muscle cells and regulate vascular tone. Here, we explored the inhibitory effect of encainide, a class Ic anti-arrhythmic agent,... -
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- Shikonin ameliorates salivary gland damage and inflammation in a mouse model of Sjögren’s syndrome by modulating MAPK signaling pathway
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Guo W, Wang X, Sun C, Wang J, Wang T
- KMID: 2544137
- Korean J Physiol Pharmacol.
- 2023 Jul;27(4):357-364.
- doi: 10.4196/kjpp.2023.27.4.357
Sjögren syndrome (SS) is a systemic inflammatory autoimmune disease that involves exocrine glands. Shikonin is extracted from comfrey, which is conventionally used as an anti-tumor, antibacterial, and antiviral drug in... -
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- PSME4 determines mesenchymal stem cell fate towards cardiac commitment through YAP1 degradation
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Kim M, Kim YS, Ahn Y, Eom GH, Yoon S
- KMID: 2544142
- Korean J Physiol Pharmacol.
- 2023 Jul;27(4):407-416.
- doi: 10.4196/kjpp.2023.27.4.407
The regeneration of myocardium following acute circulatory events remains a challenge, despite numerous efforts. Mesenchymal stem cells (MSCs) present a promising cell therapy option, but their differentiation into cardiomyocytes is... -
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- Monitoring trafficking and expression of hemagglutinin-tagged transient receptor potential melastatin 4 channel in mammalian cells
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Hwang EM, Lee BH, Byun EH, Lee S, Kang D, Lee DK, Song MS, Hong SG
- KMID: 2544143
- Korean J Physiol Pharmacol.
- 2023 Jul;27(4):417-426.
- doi: 10.4196/kjpp.2023.27.4.417
The TRPM4 gene encodes a Ca2+ -activated monovalent cation channel called transient receptor potential melastatin 4 (TRPM4) that is expressed in various tissues. Dysregulation or abnormal expression of TRPM4 has... -
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- Rectal cancer-derived exosomes activate the nuclear factor kappa B pathway and lung fibroblasts by delivering integrin beta-1
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Gao Q, An K, Gao Z, Wang Y, Ding C, Niu P, Lei F
- KMID: 2544139
- Korean J Physiol Pharmacol.
- 2023 Jul;27(4):375-381.
- doi: 10.4196/kjpp.2023.27.4.375
Numerous studies have revealed the importance of tumor-derived exosomes in rectal cancer (RC). This study aims to explore the influence of tumor-derived exosomal integrin beta-1 (ITGB1) on lung fibroblasts in... -
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- Hydrogen sulfide ameliorates abdominal aorta coarctationinduced myocardial fibrosis by inhibiting pyroptosis through regulating eukaryotic translation initiation factor 2αα phosphorylation and activating PI3K/AKT1 pathway
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Li Y, Wu Z, Hu J, Liu G, Hu H, Ouyang F, Yang J
- KMID: 2544136
- Korean J Physiol Pharmacol.
- 2023 Jul;27(4):345-356.
- doi: 10.4196/kjpp.2023.27.4.345
This study aimed to assess the effects of exogenous hydrogen sulfide (H2S) on abdominal aorta coarctation (AAC) induced myocardial fibrosis (MF) and autophagy in rats. Forty-four Sprague–Dawley rats were randomly... -
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- Circ-SNX27 sponging miR-375/RPN1 axis contributes to hepatocellular carcinoma progression
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Zheng C, Liang J, Yu S, Xu H, Dai L, Xu D
- KMID: 2544135
- Korean J Physiol Pharmacol.
- 2023 Jul;27(4):333-344.
- doi: 10.4196/kjpp.2023.27.4.333
Hepatocellular carcinoma (HCC) is a prevalent malignant tumor with high fatality. It has yet to be reported whether circ-SNX27 can affect the progression of HCC. This study attempted to analyze... -
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- Dihydroaustrasulfone alcohol induces apoptosis in nasopharyngeal cancer cells by inducing reactive oxygen speciesdependent inactivation of the PI3K/AKT pathway
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Tan KT, Shih YH, Gong JY, Zhang X, Huang CY, Su JH, Sheu JH, Lin CC
- KMID: 2544140
- Korean J Physiol Pharmacol.
- 2023 Jul;27(4):383-398.
- doi: 10.4196/kjpp.2023.27.4.383
Dihydroaustrasulfone alcohol (DA), the synthetic precursor of a natural compound (austrasulfone) isolated from the coral species Cladiella australis, has shown cytotoxic effects against cancer cells. However, it is unknown whether... -
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