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11 results

Corrigendum to: Dual mechanisms for the regulation of brain-derived neurotrophic factor by valproic acid in neural progenitor cells

Ko HM, Jin Y, Park HH, Lee JH, Jung SH, Choi SY, Lee SH, Shin CY

  • Korean J Physiol Pharmacol.
  • 2019 Jan;23(1):91-91.
  • doi: 10.4196/kjpp.2019.23.1.91
The authors note that on page 685, the acknowledgement of “This study was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MEST) (No....
Erratum to: The treatment effect of novel hGHRH homodimer to male infertility hamster

Zhang XD, Guo XY, Tang JX, Yue LN, Zhang JH, Liu T, Dong YX, Tang SS

  • Korean J Physiol Pharmacol.
  • 2019 Jan;23(1):89-89.
  • doi: 10.4196/kjpp.2019.23.1.89
The authors note that on page 637 (Author Name), author affiliation of Tao Liu “Tao Liu⁶” should instead appear as “Tao Liu⁵.”
Chronic administration of ketamine ameliorates the anxiety- and aggressive-like behavior in adolescent mice induced by neonatal maternal separation

Shin SY, Baek NJ, Han SH, Min SS

  • Korean J Physiol Pharmacol.
  • 2019 Jan;23(1):81-87.
  • doi: 10.4196/kjpp.2019.23.1.81
Ketamine has long been used as an anesthetic agent. However, ketamine use is associated with numerous side effects, including flashbacks, amnesia, delirium, and aggressive or violent behavior. Ketamine has also...
In silico evaluation of the acute occlusion effect of coronary artery on cardiac electrophysiology and the body surface potential map

Ryu AJ, Lee KE, Kwon SS, Shin ES, Shim EB

  • Korean J Physiol Pharmacol.
  • 2019 Jan;23(1):71-79.
  • doi: 10.4196/kjpp.2019.23.1.71
Body surface potential map, an electric potential distribution on the body torso surface, enables us to infer the electrical activities of the heart. Therefore, observing electric potential projected to the...
Computational analysis of the electromechanical performance of mitral valve cerclage annuloplasty using a patient-specific ventricular model

Lee KE, Kim KT, Lee JH, Jung S, Kim JH, Shim EB

  • Korean J Physiol Pharmacol.
  • 2019 Jan;23(1):63-70.
  • doi: 10.4196/kjpp.2019.23.1.63
We aimed to propose a novel computational approach to predict the electromechanical performance of pre- and post-mitral valve cerclage annuloplasty (MVCA). Furthermore, we tested a virtual estimation method to optimize...
Pharmacological evaluation of HM41322, a novel SGLT1/2 dual inhibitor, in vitro and in vivo

Lee KH, Lee SD, Kim N, Suh KH, Kim YH, Sim SS

  • Korean J Physiol Pharmacol.
  • 2019 Jan;23(1):55-62.
  • doi: 10.4196/kjpp.2019.23.1.55
HM41322 is a novel oral sodium-glucose cotransporter (SGLT) 1/2 dual inhibitor. In this study, the in vitro and in vivo pharmacokinetic and pharmacologic profiles of HM41322 were compared to those...
SPA0355 prevents ovariectomy-induced bone loss in mice

Kim SH, Zhang Z, Moon YJ, Park IW, Cho YG, Jeon R, Park BH

  • Korean J Physiol Pharmacol.
  • 2019 Jan;23(1):47-54.
  • doi: 10.4196/kjpp.2019.23.1.47
Estrogen withdrawal in post-menopausal women leads to overactivation of osteoclasts, which contributes to the development of osteoporosis. Inflammatory cytokines are known as one of mechanisms of osteoclast activation after estrogen...
Nicorandil alleviated cardiac hypoxia/reoxygenation-induced cytotoxicity via upregulating ketone body metabolism and ACAT1 activity

Bai YP, Han LS

  • Korean J Physiol Pharmacol.
  • 2019 Jan;23(1):37-45.
  • doi: 10.4196/kjpp.2019.23.1.37
To study the effect of nicorandil pretreatment on ketone body metabolism and Acetyl-CoA acetyltransferase (ACAT1) activity in hypoxia/reoxygenation (H/R)-induced cardiomyocytes. In our study, we applied H9c2 cardiomyocytes cell line to...
Decursin induces apoptosis in glioblastoma cells, but not in glial cells via a mitochondria-related caspase pathway

Oh ST, Lee S, Hua C, Koo BS, Pak SC, Kim DI, Jeon S, Shin BA

  • Korean J Physiol Pharmacol.
  • 2019 Jan;23(1):29-35.
  • doi: 10.4196/kjpp.2019.23.1.29
Decursin is a major biological active component of Angelica gigas Nakai and is known to induce apoptosis of metastatic prostatic cancer cells. Recently, other reports have been commissioned to examine...
Swertiamarin ameliorates carbon tetrachloride-induced hepatic apoptosis via blocking the PI3K/Akt pathway in rats

Zhang Q, Chen K, Wu T, Song H

  • Korean J Physiol Pharmacol.
  • 2019 Jan;23(1):21-28.
  • doi: 10.4196/kjpp.2019.23.1.21
Swertiamarin (STM) is an iridoid compound that is present in the Gentianaceae swertia genus. Here we investigated antiapoptotic effects of STM on carbon tetrachloride (CClâ‚„)-induced liver injury and its possible...
An integrated review on new targets in the treatment of neuropathic pain

Khangura R, Sharma J, Bali A, Singh N, Jaggi AS

  • Korean J Physiol Pharmacol.
  • 2019 Jan;23(1):1-20.
  • doi: 10.4196/kjpp.2019.23.1.1
Neuropathic pain is a complex chronic pain state caused by the dysfunction of somatosensory nervous system, and it affects the millions of people worldwide. At present, there are very few...

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