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Olmsted Syndrome Caused by a Heterozygous p.Gly568Val Missense Mutation in TRPV3 Gene

Choi JY, Kim SE, Lee SE, Kim SC

Olmsted syndrome (OS) is a rare congenital skin disorder characterized by severe palmoplantar and periorificial keratoderma, alopecia, onychodystrophy, and severe pruritus. Recently, pathogenic ‘gain-of-function‘ mutations of the transient receptor potential...
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Development of autoimmune hepatitis in a psoriasis patient without immunosuppressive therapy

Jo W, Suh YS, Lee SI, Cheon YH, Hong J, Lee SS, Kim JE, Ko GH, Kim HO

We present a case of a 65-year-old man with psoriasis who developed autoimmune hepatitis (AIH) without receiving immunosuppressive therapy with either anti-tumor necrosis factor-α or methotrexate. The AIH had completely...
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Intra-Articular Pigmentation of Synovium: An Unusual Cause

Verma S, Hamilton S, Liew SM

An unusual grayish brown discoloration of the synovium was found during a knee arthroscopy of a 72-year-old man. He also had similar pigmentation affecting the skin on the legs, arms,...
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Bilateral Total Hip Arthroplasty in a Rare Case of Multicentric Reticulohistiocytosis

Saibaba B, Sen RK, Das A, Sharma A

Multicentric reticulohistiocytosis (MRH) is a rare systemic disease, which commonly manifests as muco-cutaneous papulonodules and inflammatory erosive polyarthropathy. In this research, we report the clinical manifestations and management of a...
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Snakebite in Korea: A Guideline to Primary Surgical Management

Rha JH, Kwon SM, Oh JR, Han BK, Lee KH, Kim JH

PURPOSE: Snakebite is an emergency which causes local symptoms such as pain and edema around the bite. Systemic symptoms may also develop, such as dizziness or renal failure, and may...
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Identification of Somatic KRAS Mutation in a Korean Baby with Nevus Sebaceus Syndrome

Kim SW, Song JS, Kang MS, Sin JB, Ki CS, Jeon GW

No abstract available.
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Increased Expression of Cathelicidin by Direct Activation of Protease-Activated Receptor 2: Possible Implications on the Pathogenesis of Rosacea

Kim JY, Kim YJ, Lim BJ, Sohn HJ, Shin D, Oh SH

PURPOSE: Recent findings of increased cathelicidin protein and its proteolytic fragments in rosacea suggest a pathogenic role for cathelicidin in this disease. The relationship between cathelicidin and protease-activated receptor 2...
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A Case of Hypersensitivity to Mosquito Bites without Peripheral Natural Killer Cell Lymphocytosis in a 6-Year-Old Korean Boy

Seon HS, Roh JH, Lee SH, Kang EK

Hypersensitivity to mosquito bites (HMB) is a rare disease characterized by intense skin reactions such as bulla and necrotic ulcerations at bite sites, accompanied by general symptoms such as high-grade...
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Leukocytoclastic Vasculitis Associated with Influenza A Virus Infection

Lee HJ, Shin DH, Choi JS, Kim KH

Leukocytoclastic vasculitis (LCV) usually presents palpable purpura characterized by inflammation of vessel walls and fragmentation of nuclei. Various conditions can cause LCV, and it can be induced by influenza A...
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Minocycline-induced Periarticular Black Bones in Inflamed Joints Which Underwent Arthroplastic Reconstruction

Yang S, Takakubo Y, Kobayashi , Asano T, Sasaki A, Sasaki K, Ohki H, Tamaki Y, Takagi M

BACKGROUND: Minocycline-induced pigmentation of bone (black bone) is well described in tooth-bearing intra-oral bone, but is less known in periarticular bone in patients who have undergone total joint arthroplasty. On...
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Methimazole-Induced Bullous Systemic Lupus Erythematosus: A Case Report

Seo JY, Byun HJ, Cho KH, Lee EB

Bullous systemic lupus erythematosus (SLE) is a kind of LE-non-specific bullous skin disease that is rarely induced by a medication. We describe the first case of bullous SLE to develop...
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Liver Cirrhosis Due to Autoimmune Hepatitis Combined with Systemic Sclerosis

You BC, Jeong SW, Jang JY, Goo SM, Kim SG, Kim YS, Jeon CH, Jeen YM

Systemic sclerosis (SSc) is a chronic systemic disease that affects the skin, lungs, heart, gastrointestinal tract, kidneys, and musculoskeletal system. Although up to 90% of patients with scleroderma have been...
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Crohn's Disease Presenting with Erythema Nodosum as an Early Sign: A Case Report

Kang SJ, Moon W, Park MI, Kim KJ, Kim JB, Park MJ, Park SJ, Chang HK

Erythema nodosum is the most common form of septal panniculitis and the most frequent skin manifestation associated with inflammatory bowel disease, affecting up to 15% of Crohn's disease patients. Since...
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A Case of Fabry's Disease with Congenital Agammaglobulinemia

Lee KY, Jeon SY, Hong JW, Kim SE, Song KH, Kim YH, Kim KH

Fabry's disease is an X-linked lysosomal storage disorder caused by abnormalities in the alpha-galactosidase A (GLA) gene, which leads to a GLA deficiency and to the intracellular deposition of globotriaosylceramide...
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Mesenchymal Stem Cells Improve Wound Healing In Vivo via Early Activation of Matrix Metalloproteinase-9 and Vascular Endothelial Growth Factor

Kim CH, Lee JH, Won JH, Cho MK

We investigated the effects of mesenchymal stem cells (MSCs) on wound healing using a three-dimensional (3D) collagen gel scaffold. Three circular full-thickness skin defects were created on the back of...
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Hematological and Serum Biochemical Analyses in Experimental Caprine Besnoitiosis

Nazifi S, Oryan A, Namazi F

This study was undertaken to investigate the hematological and biochemical changes in experimentally infected goats with Besnoitia caprae from the time of infection till 360 days post-infection (PI). Six male...
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Incontinentia Pigmenti in a Newborn with NEMO Mutation

Lee Y, Kim S, Kim K, Chang M

Incontinentia pigmenti (IP) (OMIM #308300) is a rare X-linked dominant neuroectodermal multisystemic syndrome due to mutations in the gene for NF-kappaB essential modulator (NEMO). A term newborn girl who was...
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Hereditary Palmoplantar Keratoderma and Deafness Resulting from Genetic Mutation of Connexin 26

Lee JY, In SI, Kim HJ, Jeong SY, Choung YH, Kim YC

Gap junctions, which mediate rapid intercellular communication, consist of connexins, small transmembrane proteins that belong to a large family of proteins found throughout the species. Mutations in the GJB2 gene,...
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Inflammatory Polyarthritis in a Patient with Psoriasis: Is It Psoriatic Arthritis or Rheumatoid Arthrirtis?

Lee KH, Son MK, Ha YJ, Choi ST, Lee SW, Park YB, Lee SK

Psoriatic arthritis (PsA) is an inflammatory arthritis associated with psoriasis. There are no generally accepted diagnostic criteria for PsA. Indeed, the diagnosis of this inflammatory arthritis is made by exclusion...
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Comparison of the Efficacies of Silver-Containing Dressing Materials for Treating a Full-Thickness Rodent Wound Infected by Methicillin-resistant Staphylococcus aureus

Lee JH, Chae JD, Kim DG, Hong SH, Lee WM, Ki M

BACKGROUND: Methicillin-resistant Staphylococcus aureus (MRSA) may cause infections during wound dressing. We aimed to compare the antibacterial activities and wound-healing effects of commercially available silver-coated or silver-impregnated wound dressings on...
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