J Korean Med Sci.  2011 Feb;26(2):308-311. 10.3346/jkms.2011.26.2.308.

Incontinentia Pigmenti in a Newborn with NEMO Mutation

• Lee Y
• Kim S
• Kim K
• Chang M

• KMID: 1782125
• DOI: http://doi.org/10.3346/jkms.2011.26.2.308

Abstract

Incontinentia pigmenti (IP) (OMIM #308300) is a rare X-linked dominant neuroectodermal multisystemic syndrome due to mutations in the gene for NF-kappaB essential modulator (NEMO). A term newborn girl who was born with erythematous vesicular eruptions developed recurrent seizures during the first and second weeks of her life. The serial MRIs demonstrated diffuse, progressive brain infarctions and subsequent encephalomalacia as well as brain atrophy. Skin biopsy found it was consistent with the vesicular stage of IP. Genetic analysis revealed a deletion exon 4-10 in NEMO gene associated with IP. We hereby report a Korean female baby with IP confirmed by mutation analysis of NEMO gene.

Keyword

Incontinentia Pigmenti; NEMO Protein; Brain Infarction; Seizures; Infant, Newborn

MeSH Terms

Asian Continental Ancestry Group
Brain/pathology
DNA Mutational Analysis
Female
Humans
I-kappa B Kinase/*genetics
Incontinentia Pigmenti/*genetics/pathology
Infant, Newborn
*Mutation
Skin/pathology