J Korean Med Sci.  1987 Jun;2(2):123-127. 10.3346/jkms.1987.2.2.123.

Disseminated neonatal herpes simplex virus infection with necrotizing encephalitis: an autopsy case

• Suh YL
• Kim H
• Chi JG
• Byun HR
• Lee K

• KMID: 1730658
• DOI: http://doi.org/10.3346/jkms.1987.2.2.123

Abstract

An autopsy case of disseminated HSV type 2 infection occurring in a neonate at 32 weeks' gestation, delivered by cesarean section after premature rupture of membrane of 7 days duration, is presented. Herpes simplex virus type 2 was isolated from the vesicular skin lesion. The mother and patient had specific antibody to type 2 herpes simplex virus. Patient's parents had denied any herpetic orolabial or genital lesion during or before this pregnancy. Cultures from the cervical and vaginal swabs of the mother were negative for HSV. Postmortem examination showed hepatic necrosis, skin vesicle, devastating necrotizing inflammation of the brain, chorioretinitis and interstitial pneumonitis.

Keyword

Herpes simplex; encephalitis; neonatal infection; virus infection

MeSH Terms

Autopsy
Brain/pathology
Encephalitis/*etiology
Herpes Simplex/*congenital/pathology
Humans
Infant, Newborn
Infant, Premature, Diseases/*pathology
Liver/pathology
Male
Necrosis
Skin/pathology