- Cisplatin induces primary necrosis through poly(ADP-ribose) polymerase 1 activation in kidney proximal tubular cells
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Park S, Yoon SP, Kim J
- KMID: 2046077
- Anat Cell Biol.
- 2015 Mar;48(1):66-74.
- doi: 10.5115/acb.2015.48.1.66
Treatment with cisplatin for cancer therapy has a major side effect such as nephrotoxicity; however, the role of poly (ADP-ribose) polymerase 1 (PARP1) in necrosis in response to cisplatin nephrotoxicity... -
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- Poly(ADP-ribose) polymerase regulates glycolytic activity in kidney proximal tubule epithelial cells
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Song H, Yoon SP, Kim J
- KMID: 2308914
- Anat Cell Biol.
- 2016 Jun;49(2):79-87.
- doi: 10.5115/acb.2016.49.2.79
After renal injury, selective damage occurs in the proximal tubules as a result of inhibition of glycolysis. The molecular mechanism of damage is not known. Poly(ADP-ribose) polymerase (PARP) activation plays... -
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- Poly(ADP-ribose) polymerase 1 contributes to oxidative stress through downregulation of sirtuin 3 during cisplatin nephrotoxicity
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Yoon SP, Kim J
- KMID: 2353341
- Anat Cell Biol.
- 2016 Sep;49(3):165-176.
- doi: 10.5115/acb.2016.49.3.165
Enhanced oxidative stress is a hallmark of cisplatin nephrotoxicity, and inhibition of poly(ADP-ribose) polymerase 1 (PARP1) attenuates oxidative stress during cisplatin nephrotoxicity; however, the precise mechanisms behind its action remain... -
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- Spermidine is protective against kidney ischemia and reperfusion injury through inhibiting DNA nitration and PARP1 activation
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Kim J
- KMID: 2390481
- Anat Cell Biol.
- 2017 Sep;50(3):200-206.
- doi: 10.5115/acb.2017.50.3.200
Kidney ischemia and reperfusion injury (IRI) is associated with a high mortality rate, which is attributed to tubular oxidative and nitrative stresses; however, an effective approach to limit IRI remains... -
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- Increased Poly (ADP-ribose) Polymerase Activation in the 6-Hydroxydopamine Induced Dopaminergic Neuronal Cell Death
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Kang JH, Kang SY, Park SY, Kang HK, Park DB, Lee YK, Koh JY
- KMID: 2343084
- J Korean Neurol Assoc.
- 2004 Aug;22(4):352-359.
BACKGROUND: The pathological hallmark of Parkinson's disease (PD) is dopaminergic cell death in the substantia nigra (SN), but the cause of cell death is unknown. 6-Hydroxydopamine (6-OHDA) is one of... -
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- Melatonin Induces Apoptotic Cell Death via p53 in LNCaP Cells
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Kim CH, Yoo YM
- KMID: 2071707
- Korean J Physiol Pharmacol.
- 2010 Dec;14(6):365-369.
- doi: 10.4196/kjpp.2010.14.6.365
In this study, we examined whether melatonin promotes apoptotic cell death via p53 in prostate LNCaP cells. Melatonin treatment significantly curtailed the growth of LNCaP cells in a dose- and... -
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- Adaptive Response and Apoptosis Induced by UV Irradiation in Human Keratinocytes and Squamous Cell Carcinomas
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Moon YS
- KMID: 2128897
- Korean J Anat.
- 2007 Dec;40(4):335-345.
The present study was investigated that the effects of suitable ultraviolet (UV) irradiation to the cell viability, apoptosis and expression of poly(ADP-ribose) polymerase (PARP) in HaCaT and KUMA3 cell lines... -
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- Exogenous spermidine ameliorates tubular necrosis during cisplatin nephrotoxicity
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Yoon SP, Kim J
- KMID: 2447012
- Anat Cell Biol.
- 2018 Sep;51(3):189-199.
- doi: 10.5115/acb.2018.51.3.189
The hallmark of cisplatin-induced acute kidney injury is the necrotic cell death in the kidney proximal tubules. However, an effective approach to limit cisplatin nephrotoxicity remains unknown. Spermidine is a... -
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- Targeted therapy of ovarian cancer including immune check point inhibitor
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Kim JY, Cho CH, Song HS
- KMID: 2411480
- Korean J Intern Med.
- 2017 Sep;32(5):798-804.
- doi: 10.3904/kjim.2017.008
Epithelial ovarian cancer is the eighth most common cause of cancer-related deaths in women because most patients present with advanced stage disease at the time of diagnosis. Although cytoreductive surgery... -
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- Apoptotic Effects of 6-Gingerol in LNCaP Human Prostate Cancer Cells
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Kim HW, Oh DH, Jung C, Kwon DD, Lim YC
- KMID: 2317616
- Soonchunhyang Med Sci.
- 2011 Dec;17(2):75-79.
OBJECTIVE: 6-Gingerol, one component of ginger (Zingiber officinale) compound, has been known to possess anti-inflammatory, analgesic, anti-emetic, and anti-cancer effects. In this study, the apoptotic ability of 6-gingerol was investigated... -
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- Schedule-Dependent Effect of Epigallocatechin-3-Gallate (EGCG) with Paclitaxel on H460 Cells
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Park S, Kim JH, Hwang YI, Jung KS, Jang YS, Jang SH
- KMID: 2320492
- Tuberc Respir Dis.
- 2014 Mar;76(3):114-119.
BACKGROUND: Epigallocatechin-3-gallate (EGCG), a major biologically active component of green tea, has anti-cancer activity in human and animal models. We investigated the schedule-dependent effect of EGCG and paclitaxel on growth... -
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- Major clinical research advances in gynecologic cancer in 2017
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Suh DH, Kim M, Lee KH, Eom KY, Kjeldsen M, Mirza MR, Kim JW
- KMID: 2404021
- J Gynecol Oncol.
- 2018 Mar;29(2):e31.
- doi: 10.3802/jgo.2018.29.e31
In 2017, 10 topics were selected as major clinical research advances in gynecologic oncology. For cervical cancer, efficacy and safety analysis results of a 9-valent human papillomavirus (HPV) vaccine and... -
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- Recent Update of Molecular Targeted Therapy in Pancreatic Cancer
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Cho JH
- KMID: 1501637
- Korean J Gastroenterol.
- 2013 Mar;61(3):147-154.
- doi: 10.4166/kjg.2013.61.3.147
Pancreatic ductal adenocarcinoma is one of the most dreaded malignancies and the 5th leading cause of cancer-related death in Korea. Late diagnosis and unfavorable response to both chemotherapy and radiotherapy... -
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- Time Dependent Bladder Apoptosis Induced by Acute Bladder Outlet Obstruction and Subsequent Emptying is Associated with Decreased MnSOD Expression and Bcl-2/Bax Ratio
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Li WJ, Shin MK, Oh SJ
- KMID: 1779237
- J Korean Med Sci.
- 2010 Nov;25(11):1652-1656.
- doi: 10.3346/jkms.2010.25.11.1652
Ischemia/reperfusion (I/R) injury-induced oxidative stress plays an important role in the functional impairment of the bladder following acute bladder outlet obstruction (BOO) via induction of apoptosis. The purpose of this... -
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- Acer okamotoanum Inhibit the Hydrogen Peroxide-Induced Oxidative Stress in C6 Glial Cells
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Choi SY, Kim JH, Quilantang NG, Lee S, Cho EJ
- KMID: 2422005
- Nat Prod Sci.
- 2018 Sep;24(3):148-154.
- doi: 10.20307/nps.2018.24.3.148
Chronic oxidative stress due to the accumulation of reactive oxygen species (ROS) in neuronal cells ultimately leads to neurodegenerative diseases. The use of natural therapies for the prevention of ROS-induced... -
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- Metformin Promotes Apoptosis but Suppresses Autophagy in Glucose-Deprived H4IIE Hepatocellular Carcinoma Cells
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Park DB
- KMID: 2174005
- Diabetes Metab J.
- 2015 Dec;39(6):518-527.
- doi: 10.4093/dmj.2015.39.6.518
BACKGROUND: Metformin, a well-known anti-diabetic drug, has gained interest due to its association with the reduction of the prevalence of cancer in patients with type 2 diabetes and the anti-proliferative... -
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- Integrating a Next Generation Sequencing Panel into Clinical Practice in Ovarian Cancer
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Lee YJ, Kim D, Kim HS, Na K, Lee JY, Nam EJ, Kim SW, Kim S, Kim YT
- KMID: 2459144
- Yonsei Med J.
- 2019 Oct;60(10):914-923.
- doi: 10.3349/ymj.2019.60.10.914
PURPOSE: Few efforts have been made to integrate a next generation sequencing (NGS) panel into standard clinical treatment of ovarian cancer. The aim of this study was to investigate the... -
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- Dual Inhibition of PI3K/Akt/mTOR Pathway and Role of Autophagy in Non-Small Cell Lung Cancer Cells
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Jeong EH, Choi HS, Lee TG, Kim HR, Kim CH
- KMID: 2319806
- Tuberc Respir Dis.
- 2012 Apr;72(4):343-351.
BACKGROUND: The phosphoinositide 3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) signaling axis has emerged as a novel target for cancer therapy. Agents that inhibit this pathway are currently under development for... -
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- Radiation-Induced Autophagy Contributes to Cell Death and Induces Apoptosis Partly in Malignant Glioma Cells
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Jo GH, Bogler O, Chwae YJ, Yoo H, Lee SH, Park JB, Kim YJ, Kim JH, Gwak HS
- KMID: 2132801
- Cancer Res Treat.
- 2015 Apr;47(2):221-241.
- doi: 10.4143/crt.2013.159
PURPOSE: Radiation-induced autophagy has been shown to play two different roles, in malignant glioma (MG) cells, cytocidal or cytoprotective. However, neither the role of radiation-induced autophagy for cell death nor... -
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- A New Neolignan Derivative, Balanophonin Isolated from Firmiana simplex Delays the Progress of Neuronal Cell Death by Inhibiting Microglial Activation
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Lim SY, Subedi L, Shin D, Kim CS, Lee KR, Kim SY
- KMID: 2389384
- Biomol Ther.
- 2017 Sep;25(5):519-527.
- doi: 10.4062/biomolther.2016.224
Excessive activation of microglia causes the continuous production of neurotoxic mediators, which further causes neuron degeneration. Therefore, inhibition of microglial activation is a possible target for the treatment of neurodegenerative... -
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