- Study on the Mitochondrial Dysfunction by p53 Regulation in Ceramide-induced Neuronal Cell Death
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Lee DY, Lee HJ, Noh YH, Yun JY, Han IS, Chung YH, Kim KY, Kim SS, Lee WB
- KMID: 1512990
- Korean J Phys Anthropol.
- 2006 Mar;19(1):49-59.
Ceramide induces cell death in a dose- and time-dependent manner in neuroblastoma SK-N-SH cells. To investigate the mechanism of SK-N-SH cell death by C2-ceramide, morphological features and Hoechst 33258 staining... -
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- miR-27 regulates mitochondrial networks by directly targeting the mitochondrial fission factor
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Tak H, Kim J, Jayabalan , Lee H, Kang H, Cho DH, Ohn T, Nam SW, Kim W, Lee EK
- KMID: 2155388
- Exp Mol Med.
- 2014 Nov;46(11):e123.
- doi: 10.1038/emm.2014.73
Mitochondrial morphology is dynamically regulated by forming small, fragmented units or interconnected networks, and this is a pivotal process that is used to maintain mitochondrial homeostasis. Although dysregulation of mitochondrial... -
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- A Novel Nicotinamide Adenine Dinucleotide Correction Method for Mitochondrial Ca2+ Measurement with FURA-2-FF in Single Permeabilized Ventricular Myocytes of Rat
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Lee JH, Ha JM, Leem CH
- KMID: 2285581
- Korean J Physiol Pharmacol.
- 2015 Jul;19(4):373-382.
- doi: 10.4196/kjpp.2015.19.4.373
Fura-2 analogs are ratiometric fluoroprobes that are widely used for the quantitative measurement of [Ca2+]. However, the dye usage is intrinsically limited, as the dyes require ultraviolet (UV) excitation, which... -
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- Intracellular pH is a Critical Element in Apoptosis Triggered by GM-CSF Deprivation in TF1 Cells
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Yoon SR, Choi IP
- KMID: 2054230
- Immune Netw.
- 2003 Dec;3(4):268-275.
- doi: 10.4110/in.2003.3.4.268
BACKGROUND: Hemopoietic cells require the constant presence of growth factors for survival in vitro and in vivo. Caspases have been known as central executors of apoptotic cell death. We have,... -
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- Glucagon-Like Peptide-1 Increases Mitochondrial Biogenesis and Function in INS-1 Rat Insulinoma Cells
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Kang MY, Oh TJ, Cho YM
- KMID: 2282013
- Endocrinol Metab.
- 2015 Jun;30(2):216-220.
- doi: 10.3803/EnM.2015.30.2.216
Glucagon-like peptide-1 (GLP-1) is a gut-derived incretin hormone that increases glucose-stimulated insulin secretion in pancreatic beta-cells. Since mitochondrial function is crucial to insulin secretion, we hypothesized that GLP-1 may increase... -
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- Studies on Signal Transduction Mechanism of Alcohol-induced Neuronal Cell Death and Protective Effect
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Lee DY, Kim SS, Kim KY, Lee WB, Kim DK, Kim KH, Jung HY, Lee SH
- KMID: 1517132
- Korean J Phys Anthropol.
- 2004 Mar;17(1):31-43.
Excessive use of alcohol is a serious problem in our society and induces various, severe alcohol related diseases. The cytotoxicities of ethanol are still largely unknown. We studied the molecular... -
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- Synthesis of (4-[18F]Fluorophenyl)triphenylphosphonium as a Mitochondrial Voltage Sensor for PET
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Kim DY, Yu KH, Bom HS, Min JJ
- KMID: 1910722
- Nucl Med Mol Imaging.
- 2007 Dec;41(6):561-565.
PURPOSE: Lipophilic cations including tetraphenylphosphonium (TPP) salts penetrate the hydrophobic barriers of the plasma and mitochondrial membranes, resulting in accumulation in mitochondria in response to the negative inner transmembrane potentials.... -
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- Anti-tumor activity and mitochondrial stability of disulfiram in HL-60 cells
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- KMID: 2470118
- Korean J Vet Res.
- 2019 Dec;59(4):195-199.
- doi: 10.14405/kjvr.2019.59.4.195
Disulfiram (DSF) is a member of the dithiocarbamate family that can bind copper. Recent studies have shown that DSF has anti-cancer activities, but the mechanism has not been clarified. Therefore,... -
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- Mitochondrial Permeability Transition Pore and Cardioprotection Against Ischemia-reperfusion Injury
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Lee JW, Shim YH
- KMID: 2188082
- J Korean Med Assoc.
- 2009 Oct;52(10):1007-1019.
- doi: 10.5124/jkma.2009.52.10.1007
Opening of mitochondrial permeability transition pore (mPTP) was found to have a critical role in cell death from ischemia/reperfusion (I/R) injury experimentally in the late 1980's. Thereafter, tremendous efforts have... -
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- Genistein-Induced Apoptosis of p815 Mastocytoma Cell
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Song KH, Song KH, Kim KH
- KMID: 2158724
- Ann Dermatol.
- 2002 Jun;14(2):88-97.
- doi: 10.5021/ad.2002.14.2.88
BACKGROUND: Numerous studies demonstrated that genistein induced the decrease of proliferation and apoptosis in a variety of cells. However, there is no report about the effect of genistein on proliferation... -
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- MiR-484 Protects Rat Myocardial Cells from Ischemia-Reperfusion Injury by Inhibiting Caspase-3 and Caspase-9 during Apoptosis
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Liu H, Li S, Jiang W, Li Y
- KMID: 2470910
- Korean Circ J.
- 2020 Mar;50(3):250-263.
- doi: 10.4070/kcj.2019.0107
BACKGROUND AND OBJECTIVES: To reveal the detail mechanism of miR-484 on myocardial ischemia-reperfusion (MI/R) injury. METHODS: Rats model of MI/R injury was established based on control (Con; sham operate) group, ischemia-reperfusion... -
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- Evaluation of bioenergetic and mitochondrial function in liver transplantation
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Martins RM, Teodoro JS, Furtado E, Rolo AP, Palmeira C, Tralhão J
- KMID: 2451923
- Clin Mol Hepatol.
- 2019 Jun;25(2):190-198.
- doi: 10.3350/cmh.2018.0087
BACKGROUND/AIMS: We measured changes in mitochondrial function and bioenergetics that occur during ischemia/reperfusion in fresh liver samples of patients undergoing liver transplantation. These variations correlated with markers of liver function... -
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- Asiatic Acid Protects Dopaminergic Neurons from Neuroinflammation by Suppressing Mitochondrial ROS Production
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Chen D, Zhang XY, Sun J, Cong QJ, Chen WX, Ahsan HM, Gao J, Qian JJ
- KMID: 2456218
- Biomol Ther.
- 2019 Sep;27(5):442-449.
- doi: 10.4062/biomolther.2018.188
This study sought to evaluate the effects of Asiatic acid in LPS-induced BV2 microglia cells and 1-methyl-4-phenyl-pyridine (MPPâº)-induced SH-SY5Y cells, to investigate the potential anti-inflammatory mechanisms of Asiatic acid in... -
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- The Neuroprotective Potential of Cyanidin-3-glucoside Fraction Extracted from Mulberry Following Oxygen-glucose Deprivation
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Bhuiyan MI, Kim HB, Kim SY, Cho KO
- KMID: 2285422
- Korean J Physiol Pharmacol.
- 2011 Dec;15(6):353-361.
- doi: 10.4196/kjpp.2011.15.6.353
In this study, cyanidin-3-glucoside (C3G) fraction extracted from the mulberry fruit (Morus alba L.) was investigated for its neuroprotective effects against oxygen-glucose deprivation (OGD) and glutamate-induced cell death in rat... -
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- Kinetin inhibits apoptosis of aging spleen cells induced by D-galactose in rats
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Li M, Ouyang W, Wu X, Zheng Y, Wei Y, An L
- KMID: 2155618
- J Vet Sci.
- 2014 Sep;15(3):353-359.
- doi: 10.4142/jvs.2014.15.3.353
Kinetin (Kn) is a cytokinin growth factor that exerts several anti-aging and antioxidant effects on cells and organs. To investigate the mechanism underlying apoptotic events in aging cells induced by... -
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- Nobiletin attenuates neurotoxic mitochondrial calcium overload through K⺠influx and ΔΨ(m) across mitochondrial inner membrane
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Lee JH, Amarsanaa , Wu J, Jeon SC, Cui Y, Jung SC, Park DB, Kim SJ, Han SH, Kim HW, Rhyu IJ, Eun SY
- KMID: 2410095
- Korean J Physiol Pharmacol.
- 2018 May;22(3):311-319.
- doi: 10.4196/kjpp.2018.22.3.311
Mitochondrial calcium overload is a crucial event in determining the fate of neuronal cell survival and death, implicated in pathogenesis of neurodegenerative diseases. One of the driving forces of calcium... -
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- CM1 Ligation Induces Apoptosis via Fas-FasL Interaction in Ramos Cells, but via Down-regulation of Bcl-2 and Subsequent Decrease of Mitochondrial Membrane Potential in Raji Cells
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Lee YS, Kim YS, Kim D, Hur DY, Kang JS, Kim YI, Hahm E, Cho D, Hwang YI, Lee WJ
- KMID: 2150615
- Immune Netw.
- 2006 Jun;6(2):59-66.
- doi: 10.4110/in.2006.6.2.59
BACKGROUND: CM1 (Centrocyte/-blast Marker I) defined by a mAb developed against concanavalin-A activated PBMC, is expressed specifically on a subpopulation of centroblasts and centrocytes of human germinal center (GC) B... -
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- Mitochondrial and DNA damage in bovine somatic cell nuclear transfer embryos
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Hwang IS, Bae HK, Cheong HT
- KMID: 1705552
- J Vet Sci.
- 2013 Sep;14(3):235-240.
- doi: 10.4142/jvs.2013.14.3.235
The generation of reactive oxygen species (ROS) and subsequent mitochondrial and DNA damage in bovine somatic cell nuclear transfer (SCNT) embryos were examined. Bovine enucleated oocytes were electrofused with donor... -
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- Antitumor Effects of Camptothecin Combined with Conventional Anticancer Drugs on the Cervical and Uterine Squamous Cell Carcinoma Cell Line SiHa
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Ha SW, Kim YJ, Kim W, Lee CS
- KMID: 2071660
- Korean J Physiol Pharmacol.
- 2009 Apr;13(2):115-121.
- doi: 10.4196/kjpp.2009.13.2.115
Functional defects in mitochondria are involved in the induction of cell death in cancer cells. We assessed the toxic effect of camptothecin against the human cervical and uterine tumor... -
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- Migration and invasion of drug-resistant lung adenocarcinoma cells are dependent on mitochondrial activity
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Jeon JH, Kim DK, Shin Y, Kim HY, Song B, Lee EY, Kim JK, You HJ, Cheong H, Shin DH, Kim ST, Cheong JH, Kim SY, Jang H
- KMID: 2367553
- Exp Mol Med.
- 2016 Dec;48(12):e277.
- doi: 10.1038/emm.2016.129
A small proportion of cancer cells have stem-cell-like properties, are resistant to standard therapy and are associated with a poor prognosis. The metabolism of such drug-resistant cells differs from that... -
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