- Characterization of sphere-forming HCT116 clones by whole RNA sequencing
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Chung E, Oh I, Lee KY
- KMID: 2160947
- Ann Surg Treat Res.
- 2016 Apr;90(4):183-193.
- doi: 10.4174/astr.2016.90.4.183
PURPOSE: To determine CD133+ cells defined as cancer stem cells (CSCs) in colon cancer, we examined whether CD133+ clones in HCT116 demonstrate known features of CSCs like sphere-forming ability, chemodrug-resistance,... -
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- Withaferin-A Inhibits Colon Cancer Cell Growth by Blocking STAT3 Transcriptional Activity
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Choi BY, Kim BW
- KMID: 2380869
- J Cancer Prev.
- 2015 Sep;20(3):185-192.
- doi: 10.15430/JCP.2015.20.3.185
BACKGROUND: Withania somnifera (known as Ashwagandha) is a medicinal plant used in the ayurvedic medicines in India. Withaferin-A, a withanolide derived from the leaf extract of W. somnifera, has been... -
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- Role of p21CIP1 as a determinant of SC-560 response in human HCT116 colon carcinoma cells
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Lee E, Choi MK, Han IO, Lim SJ
- KMID: 1094159
- Exp Mol Med.
- 2006 Jun;38(3):325-331.
SC-560, a strucutral analogue of celecoxib, induces growth inhibition in a wide range of human cancer cells in a cyclooxygenase (COX)-independent manner. Since SC-560 suppresses the growth of cancer cells... -
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- Effects of DCA on Cell Cycle Proteins in Colonocytes
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Ha YH, Park DG
- KMID: 2198785
- J Korean Soc Coloproctol.
- 2010 Aug;26(4):254-259.
- doi: 10.3393/jksc.2010.26.4.254
PURPOSE: Evidence that indicates bile acid is a promoter of colon cancer exists. Deoxycholic acid (DCA) modifies apoptosis or proliferation by affecting intracellular signaling and gene expression. However, because previous... -
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- Antichemosensitizing effect of resveratrol in cotreatment with oxaliplatin in HCT116 colon cancer cell
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Park DG
- KMID: 1908500
- Ann Surg Treat Res.
- 2014 Feb;86(2):68-75.
- doi: 10.4174/astr.2014.86.2.68
PURPOSE: Although oxaliplatin is one of the most widely used chemotherapeutic agents for the treatment of advanced stages of colorectal cancers in clinic, cancer cells often develop oxaliplatin drug resistance.... -
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- Sur8 mediates tumorigenesis and metastasis in colorectal cancer
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Lee YM, Kaduwal S, Lee KH, Park JC, Jeong WJ, Choi KY
- KMID: 2361536
- Exp Mol Med.
- 2016 Jul;48(7):e249.
- doi: 10.1038/emm.2016.58
Sur8, a scaffold protein of the Ras pathway, interacts with Ras and Raf and modulates the Ras-extracellular signal-regulated kinase (ERK) pathway. Here we show that Sur8 is overexpressed in established... -
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- Balsalazide Potentiates Parthenolide-Mediated Inhibition of Nuclear Factor-kappaB Signaling in HCT116 Human Colorectal Cancer Cells
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Kim HY, Kim SL, Park YR, Liu YC, Seo SY, Kim SH, Kim IH, Lee SO, Lee ST, Kim SW
- KMID: 2174471
- Intest Res.
- 2015 Jul;13(3):233-241.
- doi: 10.5217/ir.2015.13.3.233
BACKGROUND/AIMS: Balsalazide is an anti-inflammatory drug used in the treatment of inflammatory bowel disease. Balsalazide can reduce inflammatory responses via several mechanisms, including inhibition of nuclear factor-kappaB (NF-kappaB) activity. Parthenolide... -
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- Antioxidant and growth inhibitory activities of Mesembryanthemum crystallinum L. in HCT116 human colon cancer cells
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Seo JA, Ju J
- KMID: 2444939
- J Nutr Health.
- 2019 Apr;52(2):157-167.
- doi: 10.4163/jnh.2019.52.2.157
PURPOSE: This study examined the antioxidant and cancer cell growth inhibitory activities of an ethanol extract and different solvent fractions of Mesembryanthemum crystallinum L. (ice plant). METHODS: The ice plant was... -
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- The oncogenic effects of p53-inducible gene 3 (PIG3) in colon cancer cells
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Park SJ, Kim HB, Kim J, Park S, Kim SW, Lee JH
- KMID: 2371046
- Korean J Physiol Pharmacol.
- 2017 Mar;21(2):267-273.
- doi: 10.4196/kjpp.2017.21.2.267
The p53-inducible gene 3 (PIG3), initially identified as a gene downstream of p53, plays an important role in the apoptotic process triggered by p53-mediated reactive oxygen species (ROS) production. Recently,... -
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- Induction of 90K-specific Cytotoxic T Lymphocytes for Colon Cancer Immunotherapy
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Lee JH, Park MS, Chung IJ
- KMID: 2150676
- Immune Netw.
- 2010 Dec;10(6):206-211.
- doi: 10.4110/in.2010.10.6.206
BACKGROUND: Dendritic cell (DC)-based tumor vaccine is an attractive modality for the treatment of colon cancer because it has been recurred and produced few side effects in patients. Secretory glycoprotein... -
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- 15-Deoxy-Δ(12,14)-prostaglandin J₂ Upregulates the Expression of 15-Hydroxyprostaglandin Dehydrogenase by Inducing AP-1 Activation and Heme Oxygenase-1 Expression in Human Colon Cancer Cells
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Park JM, Na HK
- KMID: 2468800
- J Cancer Prev.
- 2019 Sep;24(3):183-191.
- doi: 10.15430/JCP.2019.24.3.183
BACKGROUND: Abnormal upregulation of prostaglandin Eâ‚‚ (PGEâ‚‚) is considered to be a key oncogenic event in the development and progression of inflammation-associated human colon cancer. It has been reported that... -
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- Involvement of ROS in Curcumin-induced Autophagic Cell Death
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Lee YJ, Kim NY, Suh YA, Lee C
- KMID: 2389102
- Korean J Physiol Pharmacol.
- 2011 Feb;15(1):1-7.
Many anticancer agents as well as ionizing radiation have been shown to induce autophagy which is originally described as a protein recycling process and recently reported to play a crucial... -
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- Dexamethasone Inhibits TGF-β1-Induced Cell Migration by Regulating the ERK and AKT Pathways in Human Colon Cancer Cells Via CYR61
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Han S, Bui NT, Ho MT, Kim YM, Cho M, Shin DB
- KMID: 2344088
- Cancer Res Treat.
- 2016 Jul;48(3):1141-1153.
- doi: 10.4143/crt.2015.209
PURPOSE: One of the features in cancer development is the migration of cancer cells to form metastatic lesions. CYR61 protein promotes migration and the epithelial-mesenchymal transition in several cancer cell... -
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- Silencing the livin gene enhances the cytotoxic effects of anticancer drugs on colon cancer cells
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Oh BY, Kim KH, Chung SS, Lee RA
- KMID: 2360386
- Ann Surg Treat Res.
- 2016 Dec;91(6):273-277.
- doi: 10.4174/astr.2016.91.6.273
PURPOSE: Livin is associated with drug response in several cancers. The aim of this study was to investigate the effect of silencing the livin gene expression on anticancer drug response... -
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- Inhibition of phospholipase D2 induces autophagy in colorectal cancer cells
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Hwang WC, Kim MK, Song JH, Choi KY, Min DS
- KMID: 2155389
- Exp Mol Med.
- 2014 Dec;46(12):e124.
- doi: 10.1038/emm.2014.74
Autophagy is a conserved lysosomal self-digestion process used for the breakdown of long-lived proteins and damaged organelles, and it is associated with a number of pathological processes, including cancer. Phospholipase... -
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- IGF-1 induces expression of zinc-finger protein 143 in colon cancer cells through phosphatidylinositide 3-kinase and reactive oxygen species
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Paek AR, Kim SH, Kim SS, Kim KT, You HJ
- KMID: 964664
- Exp Mol Med.
- 2010 Oct;42(10):696-702.
- doi: 10.3858/emm.2010.42.10.068
Expression of zinc-finger protein 143 (ZNF143), a human homolog of the Xenopus transcriptional activator protein Staf, is induced by various DNA-damaging agents including etoposide, doxorubicin, and gamma-irradiation. ZNF143 binds to... -
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- PIG3 Regulates p53 Stability by Suppressing Its MDM2-Mediated Ubiquitination
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Jin M, Park SJ, Kim SW, Kim HR, Hyun JW, Lee JH
- KMID: 2386906
- Biomol Ther.
- 2017 Jul;25(4):396-403.
- doi: 10.4062/biomolther.2017.086
Under normal, non-stressed conditions, intracellular p53 is continually ubiquitinated by MDM2 and targeted for degradation. However, in response to severe genotoxic stress, p53 protein levels are markedly increased and apoptotic... -
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- Ferroptosis: A Novel Anti-tumor Action for Cisplatin
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Guo J, Xu B, Han Q, Zhou H, Xia Y, Gong C, Dai X, Li Z, Wu G
- KMID: 2411134
- Cancer Res Treat.
- 2018 Apr;50(2):445-460.
- doi: 10.4143/crt.2016.572
PURPOSE: Ferroptosis is a new mode of regulated cell death, which is completely distinct from other cell death modes based on morphological, biochemical, and genetic criteria. This study evaluated the... -
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- Effects of Genistein and Daidzein on the Growth of Human Colon Cancer HCT-116 Cells
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Shin JH, Kang KS, Kim JO, Yoon GS, Kwon TG, Kim JW, Sohn YK
- KMID: 1593161
- Korean J Pathol.
- 2006 Feb;40(1):46-51.
BACKGROUND: Genistein and daidzein are two major soybean isoflavones. They have received increasing attention because of their possible roles for cancer prevention. However, their mechanisms of action and molecular targets... -
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- D. candidum has in vitro anticancer effects in HCT-116 cancer cells and exerts in vivo anti-metastatic effects in mice
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Zhao X, Sun P, Qian Y, Suo H
- KMID: 2313768
- Nutr Res Pract.
- 2014 Oct;8(5):487-493.
- doi: 10.4162/nrp.2014.8.5.487
BACKGROUND/OBJECTIVES: D. candidum is a traditional Chinese food or medicine widely used in Asia. There has been little research into the anticancer effects of D. candidum, particularly the effects in... -
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