J Yeungnam Med Sci.  2023 Nov;40(Suppl):S81-S86. 10.12701/jyms.2023.00801.

Adult height in girls with central precocious puberty without gonadotropin-releasing hormone agonist treatment: a retrospective case-control study

• Jang HJ
• Kwak MJ
• Kim YM
• Choi SH
• Park KH
• Yoo HW
• Park SJ
• Jo YH
• Jo HY

• KMID: 2548346
• DOI: http://doi.org/10.12701/jyms.2023.00801

Abstract

Background
The primary aim of this study was to investigate the final adult height (FAH) of girls diagnosed with central precocious puberty (CPP) who were untreated.
Methods
We retrospectively analyzed the medical records of 36 girls diagnosed with CPP between 8 and 9 years of age who did not receive treatment, and 206 girls diagnosed with CPP within the same age range who received gonadotropin-releasing hormone (GnRH) agonist treatment. Midparental height (MPH), predicted adult height (PAH) obtained using height and bone age (BA) at the time of diagnosis (PAH for BA), and PAH obtained using the Bayley-Pinneau method (PAH by BP) were calculated. Additionally, height at the time of growth completion was compared with the predicted height.
Results
The FAHs were 160.71±4.56 cm in the untreated group and 159.31±4.26 cm in the treated group. In the untreated group, the FAH was 0.99±4.50 cm shorter than the MPH but 4.29±3.33 cm and 3.46±3.93 cm greater than the PAH for BA and PAH by BP, respectively.
Conclusion
In children diagnosed with CPP between 8 and 9 years of age who were untreated, FAH was greater than PAH for BA and PAH by BP at the time of diagnosis, indicating that the prognosis of FAH was not poor. Therefore, for girls diagnosed with CPP, it is recommended to consider various conditions, such as pubertal onset, height at diagnosis, BA, peak luteinizing hormone level, predicted height, and speed of puberty, when deciding whether to administer GnRH agonists.

Keyword

Central precocious puberty; Final adult height; Gonadotropin-releasing hormone agonist

Figure

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  Fig. 1. Height differences in the untreated group. Dif., difference; MPH, midparental height; PAH, predicted adult height; BA, bone age; FAH, final adult height; BP, Bayley-Pinneau. *p<0.05, statistically significant differences between the two groups.

Reference

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