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Fecal Calprotectin Levels Significantly Correlate with Polyp Size in Children and Adolescents with Juvenile Colorectal Polyps

Kim YB, Kim JY, Choi S, Lee YM, Choi SY, Kim SC, Jang HJ, Lee Y, Jeong IS, Yi DY, Kang Y, Lee KJ, Choe BH, Kang B

Purpose: We aimed to investigate factors that correlate with fecal calprotectin (FC) levels in children and adolescents with colorectal polyps. Methods: Pediatric patients aged
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Association of Sarcopenia with Heart Rate Variability

Ji JM, Koh HM, Jang JY, Moon JS, Bak HR, Jang HJ, Lee AN, Ko NG

Background: Sarcopenia and decreased heart rate variability (HRV) are reportedly associated with cardiometabolic risk factors. This study aimed to investigate the association between sarcopenia and HRV in patients who visited...
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Group 1 metabotropic glutamate receptor 5 is involved in synaptically-induced Ca2+ -spikes and cell death in cultured rat hippocampal neurons

Yang JS, Jeon S, Jang HJ, Yoon SH

Group 1 metabotropic glutamate receptors (mGluRs) can positively affect postsynaptic neuronal excitability and epileptogenesis. The objective of the present study was to determine whether group 1 mGluRs might be involved...
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Epidemiological Trends of Pediatric Inflammatory Bowel Disease in Korea: A Multicenter Study of the Last 3 Years Including the COVID-19 Era

Choi SY, Choi S, Kang B, Choe BH, Lee YJ, Park JH, Kim YB, Kim JY, Lee K, Lee KJ, Kang KS, Lee YM, Kim HJ, Kang Y, Jang HJ, Yi DY, Hong SJ, Choi YJ, Hong J, Kim SC

Background: Studies on how the coronavirus pandemic has affected pediatric inflammatory bowel disease (PIBD) are lacking. We aimed to investigate the trends in epidemiology, characteristics, initial management, and short-term outcomes...
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Cardiac Complications Associated with Eating Disorders in Children: A Multicenter Retrospective Study

Choi SY, Lee KJ, Kim SC, Lee EH, Lee YM, Kim YB, Yi DY, Kim JY, Kang B, Jang HJ, Hong SJ, Choi YJ, Kim HJ

Purpose: Eating disorders often result in somatic complications, including cardiac abnormalities. Cardiac abnormalities may involve any part of the heart, including the cardiac conduction system, and can lead to sudden...
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Bismuth-Based Quadruple Therapy versus MetronidazoleIntensified Triple Therapy as a First-Line Treatment for Clarithromycin-Resistant Helicobacter pylori Infection: A Multicenter Randomized Controlled Trial

Seo SI, Lim H, Bang CS, Yang YJ, Baik GH, Lee SP, Jang HJ, Kae SH, Kim J, Kim HY, Shin WG

Background/Aims: Clarithromycin resistance is a main factor for treatment failure in the context of Helicobacter pylori infection. However, the treatment regimen for clarithromycin-resistant H. pylori infection has not yet been determined....
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Saccharomyces boulardii and Lactulose for Childhood Functional Constipation: A Multicenter Randomized Controlled Trial

Lee KJ, Ryoo E, Lee YM, Yoon JM, Jang HJ, Choi SY, Choi YJ, Kim HJ, Chung JY, Shim JO

  • KMID: 2531219
  • J Neurogastroenterol Motil.
  • 2022 Jul;28(3):454-462.
  • doi: 10.5056/jnm21130
Background/Aims The effects of probiotics in children vary based on diseases and probiotic strains. We aim to investigate the effectiveness of Saccharomyces boulardii and lactulose for treating childhood functional constipation. Methods This open-label...
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Laboratory information management system for COVID-19 non-clinical efficacy trial data

Yoon S, Noh H, Jin H, Lee S, Han S, Kim SH, Kim J, Seo JS, Kim JJ, Park IH, Oh J, Bae JY, Lee GE, Woo SJ, Seo SM, Kim NW, Lee YW, Jang HJ, Hong SM, An SH, Lyoo KS, Yeom M, Lee H, Jung B, Yoon SW, Kang JA, Seok SH, Lee YJ, Kim SY, Kim YB, Hwang JY, On D, Lim SY, Kim SP, Jang JY, Lee H, Kim K, Lee HJ, Kim HB, Park JW, Jeong DG, Song D, Choi KS, Lee HY, Choi YK, Choi Ja, Song M, Park MS, Seo JY, Nam KT, Shin JS, Won S, Yun JW, Seong JK

Background: As the number of large-scale studies involving multiple organizations producing data has steadily increased, an integrated system for a common interoperable format is needed. In response to the coronavirus...
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Potential Utility of Fecal Calprotectin in Discriminating Colorectal Polyps From Other Major Etiologies in Children Presenting With Isolated Hematochezia

Kim YB, Kim JY, Choi S, Kim HJ, Lee YM, Lee Y, Jang HJ, Lee EH, Lee KJ, Kim SC, Choi SY, Kang Y, Yi DY, Choi YJ, Choe BH, Kang B

Background: Colorectal polyps are the most common cause of isolated hematochezia in children, which requires a colonoscopy for diagnosis. We aimed to investigate the potential utility of fecal calprotectin (FC)...
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Association between Fecal Calprotectin and Mucosal Healing in Pediatric Patients with Crohn’s Disease Who Have Achieved Sustained Clinical Remission with Anti-Tumor Necrosis Factor Agents

Lee YM, Choi S, Choe BH, Jang HJ, Kim S, Koh H, Kim ES, Kim MJ, Choe YH, Kang B

Background/Aims: Although mucosal healing (MH) is acknowledged as the treatment target in the treat-to-target era, there are limitations on repeated endoscopic examinations, especially in pediatric patients. We aimed to investigate...
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Hematometra associated with fetal death in a fennec fox (Vulpes zerda)

Kang HM, Jang HJ, Kim JH, Chang DW, Kang HG, Na KJ

A 5-year-old female fennec fox weighing 1 kg presented to the Veterinary Medical Center, Chungbuk National University with swelling of the mammary glands and hematuria. There were no significant complete...
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Clinical Implication of Hypoxic Liver Injury for Predicting Hypoxic Hepatitis and In-Hospital Mortality in ST Elevation Myocardial Infarction Patients

Choi SH, Jang HJ, Suh YJ, Park SD, Oh PC, Moon J, Lee K, Suh J, Kang W, Kim TH, Kwon SW

Purpose: In this study, we aimed to determine the value of hypoxic liver injury (HLI) in the emergency room (ER) for predicting hypoxic hepatitis (HH) and in-hospital mortality in ST...
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Anticancer Activity of Indeno[1,2-b]-Pyridinol Derivative as a New DNA Minor Groove Binding Catalytic Inhibitor of Topoisomerase IIα

Jeon KH, Shrestha A, Jang HJ, Kim JA, Sheen N, Seo M, Lee ES, Kwon Y

Topoisomerase IIα has been a representative anti-cancer target for decades thanks to its functional necessity in highly proliferative cancer cells. As type of topoisomerase IIα targeting drugs, topoisomerase II poisons...
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Diagnostic Accuracy of Fecal Calprotectin for the Detection of Small Bowel Crohn’s Disease through Capsule Endoscopy: An Updated Meta-Analysis and Systematic Review

Jung ES, Lee SP, Kae SH, Kim JH, Kim HS, Jang HJ

Background/Aims: The diagnosis of small bowel Crohn’s disease with negative ileocolonoscopic findings has been challenging. Fecal calprotectin (FC) has been used to detect colonic inflammation, but its efficacy for detecting...
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Influence of Frailty on Life Expectancy in Octogenarians After Lumbar Spine Surgery

Jang HJ, Chin DK, Park JY, Kuh SU, Kim KS, Cho YE, Kim KH

Objective: Many studies have reported positive surgical outcomes and decreased mortality after spine surgery in the elderly population, including patients between 85 and 90 years of age. Here, in addition...
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Severe Phenotype of Non-alcoholic Fatty Liver Disease in Pediatric Patients with Subclinical Hypothyroidism: a Retrospective Multicenter Study from Korea

Choi SY, Yi DY, Kim SC, Kang B, Choe BH, Lee Y, Lee YM, Lee EH, Jang HJ, Choi YJ, Kim HJ

Background: It is uncertain whether non-alcoholic fatty liver disease (NAFLD) is associated with subclinical hypothyroidism (SH) in pediatric patients. The purpose of this study was to investigated the prevalence and...
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Procedural Sedation for Pediatric Upper Gastrointestinal Endoscopy in Korea

Lee YM, Kang B, Kim YB, Kim HJ, Lee KJ, Lee Y, Choi SY, Lee EH, Yi DY, Jang HJ, Choi YJ, Hong SJ, Kim JY, Kang Y, Kim SC

Background: Sedative upper endoscopy is similar in pediatrics and adults, but it is characteristically more likely to lead to respiratory failure. Although recommended guidelines for pediatric procedural sedation are available...
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The Fate of Proximal Junctional Vertebral Fractures after Long-Segment Spinal Fixation : Are There Predictable Radiologic Characteristics for Revision surgery?

Jang HJ, Park JY, Kuh SU, Chin DK, Kim KS, Cho YE, Hahn BS, Kim KH

Objective : To investigate the radiographic characteristics of the uppermost instrumented vertebrae (UIV) and UIV+1 compression fractures that are predictive of revision surgery following long-segment spinal fixation. Methods : A total...
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The effects of direct hemoperfusion with polymyxin B-immobilized fiber in patients with acute exacerbation of interstitial lung disease

Lee JH, Park JH, Kim HJ, Kim HK, Jang JH, Kim YK, Park BS, Park SH, Kim IH, Kim SH, Heo W, Jang HJ

Background: Acute exacerbation of interstitial lung disease (AE-ILD) causes clinically significant deterioration and has an extremely poor prognosis with high mortality. Recently, several studies reported the effectiveness of direct hemoperfusion...
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Enteroscopy in Crohn’s Disease: Are There Any Changes in Role or Outcomes Over Time? A KASID Multicenter Study

Jeon SR, Kim JO, Byeon JS, Yang DH, Ko BM, Goong HJ, Jang HJ, Park SJ, Kim ER, Hong SN, Im JP, Kim SE, Koo JS, Eun CS, Chang DK, Small Intestine Research Group of the Korean Association for the Study of Intestinal Diseases (KASID)

Background/Aims: Although balloon-assisted enteroscopy (BAE) enables endoscopic visualization of small bowel (SB) involvement in Crohn’s disease (CD), there is no data on the changes in outcomes over time. We therefore...
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