Chonnam Med J.  2012 Apr;48(1):27-31. 10.4068/cmj.2012.48.1.27.

Effects of Gonadotropin-Releasing Hormone Agonist Therapy on Body Mass Index and Height in Girls with Central Precocious Puberty

Affiliations
  • 1Department of Pediatrics, Chonnam National University Medical School, Gwangju, Korea. cjkim@jnu.ac.kr

Abstract

Treatment with gonadotropin-releasing hormone (GnRH) agonist is the treatment of choice for central precocious puberty (CPP). Many of the previous studies concerning the auxological effects of treatment with GnRH agonist in CPP have focused on final height. Much less attention has been paid to changes in body weight. However, concerns have been expressed that CPP may be associated with increased body mass index (BMI) both at initial presentation and during GnRH agonist treatment. We retrospectively reviewed the height and BMI of 38 girls with CPP. All patients were treated with GnRH agonist over 18 months. The height standard deviation score (SDS) for chronological age was significantly decreased during GnRH agonist treatment, whereas the height SDS for bone age was significantly increased. The predicted adult height was increased from 157.78+/-6.45 cm before treatment to 161.41+/-8.97 cm at 12 months after treatment. The BMI SDS for chronological age was significantly increased during treatment. The BMI SDS of normal-weight girls increased more than did the BMI SDS of overweight girls, but the increase was not significant. Preventive measures, such as increased physical activity, can be introduced to minimize possible alterations in body weight, and a long-term follow-up study is required to elucidate whether GnRH agonist treatment in Korean girls with CPP affects adult obesity.

Keyword

Precocious puberty; Obesity; Gonadotropin-releasing hormone

MeSH Terms

Adult
Body Mass Index
Body Weight
Follow-Up Studies
Gonadotropin-Releasing Hormone
Humans
Motor Activity
Obesity
Overweight
Piperazines
Puberty, Precocious
Retrospective Studies
Gonadotropin-Releasing Hormone
Piperazines

Figure

  • FIG. 1 Changes in the height SDS and BMI SDS for chronological age during GnRH agonist treatment. *p< 0.05 compared to before treatment. BMI: body mass index, HT: height, SDS: standard deviation score, CA: chronological age.

  • FIG. 2 Changes in the height SDS and BMI SDS for bone age during GnRH agonist treatment. *p<0.05 compared to before treatment. BMI: body mass index, HT: height, SDS: standard deviation score, BA: bone age.


Cited by  3 articles

Change in body mass index and insulin resistance after 1-year treatment with gonadotropin-releasing hormone agonists in girls with central precocious puberty
Jina Park, Jae Hyun Kim
Ann Pediatr Endocrinol Metab. 2017;22(1):27-35.    doi: 10.6065/apem.2017.22.1.27.

The different effects of gonadotropin-releasing hormone agonist therapy on body mass index and growth between normal-weight and overweight girls with central precocious puberty
Won Jun Yang, Keun Hyeok Ko, Kon Hee Lee, Il Tae Hwang, Yeon Joung Oh
Ann Pediatr Endocrinol Metab. 2017;22(1):49-54.    doi: 10.6065/apem.2017.22.1.49.

Relationship between serum insulin-like growth factor-1, IGF binding protein-3 levels and body height before and after gonadotropin-releasing hormone agonist therapy
Han Sol Song, Won Bok Choi, Joon Sup Song, Il Tae Hwang, Seung Yang
Ann Pediatr Endocrinol Metab. 2014;19(4):208-213.    doi: 10.6065/apem.2014.19.4.208.


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