Psychiatry Investig.  2022 Feb;19(2):100-109. 10.30773/pi.2021.0335.

Baseline Clinical and Biomarker Characteristics of Biobank Innovations for Chronic Cerebrovascular Disease With Alzheimer’s Disease Study: BICWALZS

Affiliations
  • 1Department of Psychiatry, Ajou University School of Medicine, Suwon, Republic of Korea
  • 2Department of Gastroenterology, Ajou University School of Medicine, Suwon, Republic of Korea
  • 3Human Genome Research and Bio-Resource Center, Ajou University Medical Center, Suwon, Republic of Korea
  • 4Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea
  • 5Department of Neurology, Inha University School of Medicine, Incheon, Republic of Korea
  • 6Department of Neurology, Pusan National University Hospital, Pusan National University School of Medicine and Medical Research Institute, Busan, Republic of Korea
  • 7Department of Neurology, Chonnam National University Medical School, Chonnam National University Hospital, Gwangju, Republic of Korea
  • 8Department of Psychiatry, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea
  • 9Department of Brain Science, Ajou University School of Medicine, Suwon, Republic of Korea
  • 10Department of Biomedical Sciences, Ajou University Graduate School of Medicine, Suwon, Republic of Korea
  • 11Department of Biomedical Systems Informatics, Yonsei University College of Medicine, Yongin, Republic of Korea
  • 12Department of Radiology, Ajou University School of Medicine, Seoul, Republic of Korea
  • 13Department of Nuclear Medicine and Molecular Imaging, Ajou University School of Medicine, Suwon, Republic of Korea
  • 14Department of Dermatology, Ajou University School of Medicine, Suwon, Republic of Korea
  • 15Department of Industrial Engineering, Ajou University, Suwon, Republic of Korea
  • 16Department of Artificial Intelligence, Ajou University, Suwon, Republic of Korea
  • 17Department of Biomedical Informatics, Ajou University School of Medicine, Suwon, Republic of Korea
  • 18Office of Biostatistics, Ajou Research Institute for Innovative Medicine, Ajou University Medical Center, Suwon, Republic of Korea

Abstract


Objective
We aimed to present the study design and baseline cross-sectional participant characteristics of biobank innovations for chronic cerebrovascular disease with Alzheimer’s disease study (BICWALZS) participants.
Methods
A total of 1,013 participants were enrolled in BICWALZS from October 2016 to December 2020. All participants underwent clinical assessments, basic blood tests, and standardized neuropsychological tests (n=1,013). We performed brain magnetic resonance imaging (MRI, n=817), brain amyloid positron emission tomography (PET, n=713), single nucleotide polymorphism microarray chip (K-Chip, n=949), locomotor activity assessment (actigraphy, n=200), and patient-derived dermal fibroblast sampling (n=175) on a subset of participants.
Results
The mean age was 72.8 years, and 658 (65.0%) were females. Based on clinical assessments, total of 168, 534, 211, 80, and 20 had subjective cognitive decline, mild cognitive impairment (MCI), Alzheimer’s dementia, vascular dementia, and other types of dementia or not otherwise specified, respectively. Based on neuroimaging biomarkers and cognition, 199, 159, 78, and 204 were cognitively normal (CN), Alzheimer’s disease (AD)-related cognitive impairment, vascular cognitive impairment, and not otherwise specified due to mixed pathology (NOS). Each group exhibited many differences in various clinical, neuropsychological, and neuroimaging results at baseline. Baseline characteristics of BICWALZS participants in the MCI, AD, and vascular dementia groups were generally acceptable and consistent with 26 worldwide dementia cohorts and another independent AD cohort in Korea.
Conclusion
The BICWALZS is a prospective and longitudinal study assessing various clinical and biomarker characteristics in older adults with cognitive complaints. Details of the recruitment process, methodology, and baseline assessment results are described in this paper.

Keyword

Alzheimer’s disease; Vascular dementia; Subcortical vascular cognitive impairment; Mild cognitive impairment; Dementia; Cohort
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