J Vet Sci.  2020 Jan;21(1):e8. 10.4142/jvs.2020.21.e8.

Sevoflurane with opioid or dexmedetomidine infusions in dogs undergoing intracranial surgery: a retrospective observational study

Affiliations
  • 1Dick White Referrals, Six Mile Bottom, CB8 0UH, UK. felipe.marquez@dwr.co.uk

Abstract

This study reports the clinical use of two sevoflurane-based anesthetic techniques in dogs undergoing craniectomy. Twenty-one animals undergoing elective rostrotentorial or transfrontal craniectomy for brain tumor excision, anesthetized with sevoflurane, were enrolled in this retrospective, observational study. Anesthetic records were allocated to two groups: Sevo-Op (sevoflurane and short acting opioid infusion): 8 dogs and Sevo-Dex (sevoflurane and dexmedetomidine infusion): 13 dogs. Average mean arterial pressure (MAP), heart rate, end-tidal carbon dioxide, end-tidal sevoflurane and intraoperative infusion rates during surgery were calculated. Presence of intra-operative and post-operative bradycardia, tachycardia, hypotension, hypertension, hypothermia, hyperthermia was recorded. Time to endotracheal extubation, intraoperative occurrence of atrioventricular block, postoperative presence of agitation, seizures, use of labetalol and dexmedetomidine infusion were also recorded. Data from the two groups were compared with Fisher's exact test and unpaired t tests with Welch's correction. Odds ratio (OR) and 95% confidence interval (CI) were calculated for categorical variables. Intra-operatively, MAP was lower in Sevo-Op [85 (± 6.54) vs. 97.69 (± 7.8) mmHg, p = 0.0009]. Time to extubation was longer in Sevo-Dex [37.69 (10-70) vs. 19.63 (10-25), p = 0.0033]. No differences were found for the other intra-operative and post-operative variables investigated. Post-operative hypertension and agitation were the most common complications (11 and 12 out of 21 animals, respectively). These results suggest that the infusion of dexmedetomidine provides similar intra-operative conditions and post-operative course to a short acting opioid infusion during sevoflurane anesthesia in dogs undergoing elective rostrotentorial or transfrontal intracranial surgery.

Keyword

Anesthesia; dexmedetomidine; neurosurgery; sevoflurane

MeSH Terms

Airway Extubation
Anesthesia
Animals
Arterial Pressure
Atrioventricular Block
Bradycardia
Brain Neoplasms
Carbon Dioxide
Dexmedetomidine*
Dihydroergotamine
Dogs*
Fever
Heart Rate
Hypertension
Hypotension
Hypothermia
Labetalol
Neurosurgery
Observational Study*
Odds Ratio
Retrospective Studies*
Seizures
Tachycardia
Carbon Dioxide
Dexmedetomidine
Dihydroergotamine
Labetalol
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