- Treatment of Opioid Withdrawal Syndrome Triggered by Oxycodone/Naloxone with Dexmedetomidine
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Go SI, Kim JH, Kang JH
- KMID: 2540099
- Korean J Hosp Palliat Care.
- 2023 Mar;26(1):18-21.
- doi: 10.14475/jhpc.2023.26.1.18
The combination of oxycodone and naloxone is useful for cancer pain management. Naloxone, as a pure opioid antagonist, cannot be used simultaneously with opioids. However, owing to its low bioavailability,... -
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- Intrathecal dexmedetomidine attenuates mechanical allodynia through the downregulation of brain-derived neurotrophic factor in a mild traumatic brain injury rat model
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Jeon S, Baik J, Kim J, Lee J, Do W, Kim E, Lee HJ, Kim H
- KMID: 2538890
- Korean J Anesthesiol.
- 2023 Feb;76(1):56-66.
- doi: 10.4097/kja.22209
Background: This study evaluated the effects of dexmedetomidine and propofol on brain-derived neurotrophic factor level in the cerebrospinal fluid (c-BDNF) and mechanical allodynia in a mild traumatic brain injury (TBI)... -
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- Comparison of vital sign stability and cost effectiveness between midazolam and dexmedetomidine during third molar extraction under intravenous sedation
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Kim JY, Park SY, Han YS, Lee H
- KMID: 2537560
- J Korean Assoc Oral Maxillofac Surg.
- 2022 Dec;48(6):348-355.
- doi: 10.5125/jkaoms.2022.48.6.348
Objectives: To compare the vital sign stability and cost of two commonly used sedatives, midazolam (MDZ) and dexmedetomidine (DEX). Patients and Methods: This retrospective study targeted patients who underwent mandibular third... -
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- Improved postoperative recovery profile in pediatric oral rehabilitation with low-dose dexmedetomidine as an opioid substitute for general anesthesia: a randomized double-blind clinical trial
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Naveen NB, Jaiswal MK, Ganesh V, Singh A, Meena SC, Amburu V, Soni SL
- KMID: 2533861
- J Dent Anesth Pain Med.
- 2022 Oct;22(5):357-367.
- doi: 10.17245/jdapm.2022.22.5.357
Background: Low-dose dexmedetomidine may be a suitable alternative to opioids for pediatric ambulatory procedures under general anesthesia (GA). However, the recovery profile remains unclear. Herein, we aimed to evaluate the... -
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- Comparison of dexmedetomidine alone with dexmedetomidine and fentanyl during awake fiberoptic intubation in patients with difficult airway: a randomized clinical trial
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Acharya R, Sriramka B, Koushik P
- KMID: 2533860
- J Dent Anesth Pain Med.
- 2022 Oct;22(5):349-356.
- doi: 10.17245/jdapm.2022.22.5.349
Background: Awake fiberoptic intubation (AFOI) is the procedure of choice for securing the airway in patients with a difficult airway when undergoing surgeries under general anesthesia. An ideal drug would... -
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- Dexmedetomidine and LPS co-treatment attenuates inflammatory response on WISH cells via inhibition of p38/NF-kB signaling pathway
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Kim TS, Yoon JY, Kim CH, Choi EJ, Kim YH, Kim EJ
- KMID: 2532221
- J Dent Anesth Pain Med.
- 2022 Aug;22(4):277-287.
- doi: 10.17245/jdapm.2022.22.4.277
Background: Inflammatory dental diseases that occur during pregnancy can cause preterm labor and/or intrauterine growth restriction. Therefore, proactive treatment of dental diseases is necessary during pregnancy. Dexmedetomidine (DEX) is a... -
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- Comparative evaluation of propofol versus dexmedetomidine infusion for hypotensive anesthesia during functional endoscopic sinus surgery: a prospective randomized trial
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Gupta KK, Kumari V, Kaur S, Singh A
- KMID: 2535319
- Anesth Pain Med.
- 2022 Jul;17(3):271-279.
- doi: 10.17085/apm.21118
Background: During functional endoscopic sinus surgery (FESS), intranasal bleeding affects operative field visibility and increases the frequency of complications. Therefore, hypotensive anesthesia is a widely used technique to improve surgical... -
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- Sparing effect of tramadol, lidocaine, dexmedetomidine and their combination on the minimum alveolar concentration of sevoflurane in dogs
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El-Hawari SF, Oyama N, Koyama Y, Tamura J, Itami T, Sano T, Yamashita K
- KMID: 2532287
- J Vet Sci.
- 2022 Jul;23(4):e53.
- doi: 10.4142/jvs.21305
Background: Problems associated with using inhalational anaesthesia are numerous in veterinary anaesthesia practice. Decreasing the amount of used inhalational anaesthetic agents and minimising of cardiorespiratory disorders are the standard goals... -
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- Preoperative dexmedetomidine and intraoperative bradycardia in laparoscopic cholecystectomy: a meta-analysis with trial sequential analysis
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De Cassai A, Sella N, Geraldini F, Zarantonello F, Pettenuzzo T, Pasin L, Iuzzolino M, Rossini N, Pesenti E, Zecchino G, Munari M, Navalesi P, Boscolo A
- KMID: 2530012
- Korean J Anesthesiol.
- 2022 Jun;75(3):245-254.
- doi: 10.4097/kja.21359
Background: While laparoscopic surgical procedures have various advantages over traditional open techniques, artificial pneumoperitoneum is associated with severe bradycardia and cardiac arrest. Dexmedetomidine, an imidazole derivative that selectively binds to... -
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- Does dexmedetomidine combined with levobupivacaine in inferior alveolar nerve blocks among patients undergoing impacted third molar surgery control postoperative morbidity?
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Patil SM, Jadhav A, Bhola N, Hingnikar P, Kshirsagar K, Patil D
- KMID: 2527605
- J Dent Anesth Pain Med.
- 2022 Apr;22(2):145-153.
- doi: 10.17245/jdapm.2022.22.2.145
Background: Postoperative analgesia (POA) is an important determinant of successful treatment. Dexmedetomidine (DEX) has recently gained attention as a promising adjuvant to local anesthetics (LA). The present study aimed to... -
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- Comparison of nebulized dexmedetomidine and ketamine for premedication in pediatric patients undergoing hernia repair surgery: a randomized comparative trial
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Singariya G, Malhotra N, Kamal M, Jaju R, Aggarwal S, Bihani P
- KMID: 2531693
- Anesth Pain Med.
- 2022 Apr;17(2):173-181.
- doi: 10.17085/apm.21081
Background: Allaying anxiety and providing calm children in the operating room is a challenging task for anesthesiologists. This study was designed to compare the use of nebulized dexmedetomidine and ketamine... -
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- Evaluation of the Effect of Continuous Infusion of Dexmedetomidine or a Subanesthetic Dose Ketamine on Transcranial Electrical Motor Evoked Potentials in Adult Patients Undergoing Elective Spine Surgery under Total Intravenous Anesthesia: A Randomized Controlled Exploratory Study
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Andleeb R, Agrawal S, Gupta P
- KMID: 2529528
- Asian Spine J.
- 2022 Apr;16(2):221-230.
- doi: 10.31616/asj.2021.0015
Study Design: Prospective, randomized, placebo-controlled, double-blind exploratory study. Purpose: To compare effects of dexmedetomidine or a subanesthetic dose of ketamine on the amplitude and latency of transcranial electrically generated motor evoked... -
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- Feasibility of non-invasive recording of somatosensory evoked potential in pigs
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Hoareau GL, Peters A, Hilgart D, Iversen M, Clark G, Zabriskie M, Rieke V, Floyd C, Shah L
- KMID: 2527825
- Lab Anim Res.
- 2022 Mar;38(1):61-66.
- doi: 10.1186/s42826-022-00118-3
Background: Non-invasive measurement of somatosensory-evoked potentials (SEP) in a large animal model is important to translational cognitive research. We sought to develop a methodology for neurophysiological recording via a transcranial... -
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- Verification of the performance of the Bispectral Index as a hypnotic depth indicator during dexmedetomidine sedation
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Ki S, Lee D, Lee W, Cho K, Han Y, Lee J
- KMID: 2526526
- Anesth Pain Med.
- 2022 Jan;17(1):44-51.
- doi: 10.17085/apm.21065
Background: Differences in the effects of propofol and dexmedetomidine sedation on electroencephalogram patterns have been reported previously. However, the reliability of the Bispectral Index (BIS) value for assessing the sedation... -
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- Effect of Sedatives on In-hospital and Long-term Mortality of Critically Ill Patients Requiring Extended Mechanical Ventilation for ≥ 48 Hours
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Lee H, Choi S, Jang EJ, Lee J, Kim D, Yoo S, Oh SY, Ryu HG
- KMID: 2519597
- J Korean Med Sci.
- 2021 Aug;36(34):e221.
- doi: 10.3346/jkms.2021.36.e221
Background: The purpose of this study was to assess the correlation between sedatives and mortality in critically ill patients who required mechanical ventilation (MV) for ≥ 48 hours from 2008... -
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- The correlation between the STOP-Bang score and oxygen saturation during spinal anesthesia with dexmedetomidine sedation
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Yun M, Kim J, Ryu S, Han S, Shin Y
- KMID: 2519062
- Anesth Pain Med.
- 2021 Jul;16(3):305-311.
- doi: 10.17085/apm.21011
Background: The STOP-BANG questionnaire is a simple screening tool with high sensitivity for the detection of severe obstructive sleep apnea (OSA). Predicting airway obstruction would allow the safe management of... -
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- Dexmedetomidine as an adjunctive treatment for acute asthma
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Motamed H, Forouzan A, Moezzi M, Alizadeh H
- KMID: 2517604
- Clin Exp Emerg Med.
- 2021 Jun;8(2):89-93.
- doi: 10.15441/ceem.20.038
Objective This study aimed to compare the efficacy of using dexmedetomidine with salbutamol and salbutamol nebulization alone in patients with acute exacerbation of asthma presenting to the emergency department. Methods This... -
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- Influence of Epidural Ropivacaine with or without Dexmedetomidine on Postoperative Analgesia and Patient Satisfaction after Thoraco-Lumbar Spine Instrumentation: A Randomized, Comparative, and Double-Blind Study
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Qureshi F, Meena SC, Kumar V, Jain K, Chauhan R, Luthra A
- KMID: 2516778
- Asian Spine J.
- 2021 Jun;15(3):324-332.
- doi: 10.31616/asj.2020.0072
Study Design This was a prospective, randomized, and double-blind study. Purpose Thoraco-lumbar spine surgery is associated with severe postoperative pain and can cause chronic pain. We aimed to compare the impact of epidural... -
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- Effect of preoperative dexmedetomidine nebulization on the hemodynamic response to laryngoscopy and intubation: a randomized control trial
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Misra S, Behera BK, Mitra JK, Sahoo AK, Jena SS, Srinivasan A
- KMID: 2514498
- Korean J Anesthesiol.
- 2021 Apr;74(2):150-157.
- doi: 10.4097/kja.20153
Background: Dexmedetomidine, an alpha-2 agonist, has been used for attenuation of hemodynamic response to laryngoscopy but not through the nebulized route. We evaluated the effects of preoperative dexmedetomidine nebulization on... -
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- Neuroprotection of the Developing Brain by Dexmedetomidine Is Mediated by Attenuating Single Propofol-induced Hippocampal Apoptosis and Synaptic Plasticity Deficits
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Sun Wc, Wang J, Cai D, Pei L
- KMID: 2508472
- Exp Neurobiol.
- 2020 Oct;29(5):356-375.
- doi: 10.5607/en20032
Dexmedetomidine (DEX) has neuroprotective effects and its efficacy was determined in propofol-treated pups. Postnatal day (P) 7 rats were exposed to propofol and DEX to investigate the induced apoptosis-related gene... -
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