Korean J Fam Med.  2019 Sep;40(5):289-296. 10.4082/kjfm.19.0087.

Recent Advances in Anti-Aging Medicine

  • 1Department of Family Medicine, Yonsei University College of Medicine, Seoul, Korea. ukyjhome@yuhs.ac
  • 2Department of Internal Medicine, Incheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Incheon, Korea.


A rapidly aging population in Korea has led to increased attention in the field of anti-aging medicine. The purpose of anti-aging medicine is to slow, stop, or reverse the aging process and its associated effects, such as disability and frailty. Anti-aging medicine is emerging as a growing industry, but many supplements or protocols are available that do not have scientific evidence to support their claims. In this review, the mechanisms of action and the clinical implications of anti-aging interventions were examined and explained. Calorie restriction mimetics define compounds that imitate the outcome of calorie restriction, including an activator of AMP protein kinase (metformin), inhibitor of growth hormone/insulin-like growth factor-1 axis (pegvisomant), inhibitor of mammalian target of rapamycin (rapamycin), and activator of the sirtuin pathway (resveratrol). Hormonal replacement has also been widely used in the elderly population to improve their quality of life. Manipulating healthy gut microbiota through prebiotic/probiotics or fecal microbiota transplantation has significant potential in anti-aging medicine. Vitamin D is expected to be a primary anti-aging medicine in the near future due to its numerous positive effects in the elderly population.


Aging; Hormone Replacement Therapy; Calorie Restriction; Vitamin D

MeSH Terms

Fecal Microbiota Transplantation
Gastrointestinal Microbiome
Hormone Replacement Therapy
Protein Kinases
Quality of Life
Vitamin D
Protein Kinases
Vitamin D
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