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Multifaceted Actions of Succinate as a Signaling Transmitter Vary with Its Cellular Locations

Guo Y, Cho SW, Saxena D, Li X

Since the identification of succinate's receptor in 2004, studies supporting the involvement of succinate signaling through its receptor in various diseases have accumulated and most of these investigations have highlighted...
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Imbalance of Gut Streptococcus, Clostridium, and Akkermansia Determines the Natural Course of Atopic Dermatitis in Infant

Park YM, Lee SY, Kang MJ, Kim BS, Lee MJ, Jung SS, Yoon JS, Cho HJ, Lee E, Yang SI, Seo JH, Kim HB, Suh DI, Shin YH, Kim KW, Ahn K, Hong SJ

PURPOSE: The roles of gut microbiota on the natural course of atopic dermatitis (AD) are not yet fully understood. We investigated whether the composition and function of gut microbiota and...
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The human gastrointestinal microbiota and prostate cancer development and treatment

Sha S, Ni L, Stefil M, Dixon M, Mouraviev

The human gastrointestinal microbiome contains commensal bacteria and other microbiota that have been gaining increasing attention in the context of cancer development and response to treatment. Microbiota play a role...
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Minocycline and Its Impact on Microbial Dysbiosis in the Skin and Gastrointestinal Tract of Acne Patients

Thompson K, Rainer BM, Antonescu , Florea L, Mongodin E, Kang S, Chien AL

BACKGROUND: Associations between acne and gastrointestinal comorbidities suggest that microbial dysbiosis and intestinal permeability may promote inflammatory acne, a condition often managed with oral antibiotics. OBJECTIVE: We performed a case-control study...
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Prebiotics in the Infant Microbiome: The Past, Present, and Future

Miqdady M, Al Mistarihi J, Azaz A, Rawat D

The latest definition of a prebiotic is “a substrate that is selectively utilized by host microorganisms conferring a health benefit”; it now includes non-food elements and is applicable to extra-intestinal...
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Hypervirulent Klebsiella pneumoniae: Liver Abscess Isolates versus Intestinal Flora

Chung DR

No abstract available.
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Sex Differences in Gut Microbiota

Kim YS, Unno T, Kim BY, Park MS

Humans carry numerous symbiotic microorganisms in their body, most of which are present in the gut. Although recent technological advances have produced extensive research data on gut microbiota, there are...
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Antibiotics-Induced Dysbiosis of Intestinal Microbiota Aggravates Atopic Dermatitis in Mice by Altered Short-Chain Fatty Acids

Kim HJ, Lee SH, Hong SJ

PURPOSE: Alterations in the intestinal microbiota in early life affects the development of atopic dermatitis (AD) in humans. This study aimed to further investigate the effects of gut dysbiosis in...
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Effect of Diet on the Gut Microbiota Associated with Obesity

Kim B, Choi HN, Yim JE

Obesity is abnormal or excessive fat accumulation that is associated with progression of metabolic diseases including type 2 diabetes mellitus, cardiovascular disease, nonalcoholic fatty liver disease, and cancer. Gut microbiota...
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Role of Gut Microbiota in Type 2 Diabetes Mellitus and Its Complications: Novel Insights and Potential Intervention Strategies

Woldeamlak B, Yirdaw K, Biadgo B

Type 2 diabetes mellitus has become one of the fastest growing public health problems worldwide. The disease is believed to involve a complex process involving genetic susceptibility and environmental factors....
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Analysis of Intestinal Mucosal Microbiome Changes before and after Chemoradiation in Locally Advanced Rectal Cancer Patients

Seo I, Bae SU, Kim S, Jeong WK, Baek SK

PURPOSE: Dysbiosis of gut microbiota has been reported to participate in the pathogenesis of colorectal cancer, but changes in microbiota due to radiotherapy have not been studied. In this study,...
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Characteristics of Faecal Microbiota in Korean Patients with Clostridioides difficile-associated Diarrhea

Jeon YD, Ann HW, Lee WJ, Kim JH, Seong H, Kim JH, Ahn JY, Jeong SJ, Ku NS, Yeom JS, Yong D, Lee K, Choi JY

BACKGROUND: The intestinal microbiota plays an important role in the pathogenesis of Clostridioides difficile-associated diarrhea, and regional and racial characteristics influence the microbiome composition and diversity. We investigated the intestinal...
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New Perspectives in Pediatric Nonalcoholic Fatty Liver Disease: Epidemiology, Genetics, Diagnosis, and Natural History

Ko JS

Nonalcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease in children. The global prevalence of pediatric NAFLD from general populations is 7.6%. In obese children,...
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Importance of nutritional therapy in the management of intestinal diseases: beyond energy and nutrient supply

Kim SE

The gut is an immune-microbiome-epithelial complex. Gut microbiome-host interactions have widespread biological implications, and the role of this complex system extends beyond the digestion of food and nutrient absorption. Dietary...
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The Role of the Gut Microbiota in Obesity

Kim H, Baeg MK, Kim JH, Diet, Obesity, and Metabolism Research Group of Korean Society of Neurogastroenterology and Motility

Obesity is a critical target for public health interventions worldwide. There are many causes of obesity, and the importance of the gut microbiota in its pathogenesis has recently been recognized....
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Systemic Sclerosis and Microbiota: Overview of Current Research Trends and Future Perspective

Kim S, Chun SH, Park HJ, Lee SI

The commensal microbiota contributes to the maintenance of immune homeostasis in the human body. Autoimmunity can be aggravated or alleviated by the microbiota, which affects both innate and adaptive immune...
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Sex-related Alterations of Gut Microbiota in the C57BL/6 Mouse Model of Inflammatory Bowel Disease

Son HJ, Kim N, Song CH, Nam RH, Choi SI, Kim JS, Lee DH

BACKGROUND: Gut microbiota is closely associated with development and exacerbation of inflammatory bowel diseases (IBD). The aim of this study was to investigate differences in gut microbiota depending on sex...
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Elevation of the Gut Microbiota Metabolite Trimethylamine N-Oxide Predicts Stroke Outcome

Nam HS, Ha J, Ji D, Kwon I, Lee HS, Han M, Kim YD, Heo JH, Lee SG

No abstract available.
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Exercise, the Gut Microbiome, and Frailty

Shin HE, Kwak SE, Lee JH, Zhang D, Bae JH, Song W

The gut microbiome is deeply associated with both skeletal muscle and brain function. In particular, gut microbiome dysbiosis may accelerate age-related diseases by affecting these systems. Although there is increasing...
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The interaction between gut microbiome and nutrients on development of human disease through epigenetic mechanisms

Lee HS

Early environmental exposure is recognized as a key factor for long-term health based on the Developmental Origins of Health and Disease hypothesis. It considers that early-life nutrition is now being...
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