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Assessment of Meningeal Lymphatics in the Parasagittal Dural Space: A Prospective Feasibility Study Using Dynamic Contrast-Enhanced Magnetic Resonance Imaging

Joo B, Park M, Ahn SJ, Suh SH

Objective: Meningeal lymphatic vessels are predominantly located in the parasagittal dural space (PSD); these vessels drain interstitial fluids out of the brain and contribute to the glymphatic system. We aimed...
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Mitochondrial-Encoded Peptide MOTS-c, Diabetes, and Aging-Related Diseases

Kong BS, Lee C, Cho YM

Mitochondria are complex metabolic organelles with manifold pathophysiological implications in diabetes. Currently published mitochondrial-encoded peptides, which are expressed from the mitochondrial open reading frame of the 12S ribosomal RNA type-c...
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The effects of cement thickness and cement shade on the final color of lithium disilicate crowns

Yamalı Y, Güngör MB, Nemli SK, Bal BT

PURPOSE The aim of this study is to evaluate the effect of resin cement color, cement thickness, and thermocycling on the final color of monolithic lithium disilicate crowns. MATERIALS AND METHODS A total...
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Risk Factors for Various Cognitive Function Decline Trajectories in Adults Over 40 Years of Age: A Retrospective Cohort Study

Han S, Lee JY, Cho Si, Oh DJ, Yoon DH

Objective The aims of our study were to identify distinct trajectories of cognitive function using the group-based trajectory model. We also investigate which demographic factors act as risk factors for...
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The effect of disease-modifying antirheumatic drugs on sleep and quality of life in older patients with rheumatoid arthritis

Azizli A, Sargın G, Senturk T

Objective: The sleep quality is worse in rheumatoid arthritis (RA) patients than in healthy controls and it is more difficult to achieve a satisfactory quality of life after treatment with...
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Effects of Age and Multiple Vaginal Births on Lower Urinary Tract Structure and Function in Nonhuman Primates

Williams JK, Andersson KE, Lankford S, Badlani G

Purpose: The relative roles of urinary sphincter damage, aging, and childbirth in stress urinary incontinence (SUI), have not been established. This study was performed to elucidate the roles of these...
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The Function of Body Mass Index in the Older with Osteosarcopenia: A Systematic Review and Meta-analysis

Du Y, Tao S, Oh C, No J

Background: Due to the aging population worldwide, diseases that frequently attack elderly people, such as sarcopenia and osteoporosis, are major public health issues. Methods: This study used a systematic review and...
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Temporal Change in the Use of Laboratory and Imaging Tests in One Week Before Death, 2006–2015

Kim HA, Cho M, Son DS

Background: To analyze the trends in laboratory and imaging test use 1 week before death among decedents who died in Korean hospitals, tests used per decedents from 2006 to 2015...
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Longitudinal Changes in Physical and Cognitive Functions among Participants with and without Rheumatoid Arthritis in Community-Dwelling Middle-Aged and Older Adults

Yasuoka M, Tange C, Nishita Y, Tomida M, Watanabe R, Shimokata H, Otsuka R, Kojima M

Background: This study evaluated the chronological changes in physical and cognitive functions in middle-aged and older adults with and without rheumatoid arthritis (RA). Methods: This population-based case-control longitudinal study included individuals...
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Knowledge of Sarcopenia and Associated Factors Among the Malaysian General Public: A Cross-sectional Study

Keng SL, Seman NHC, Krishnan K, Bee CJ, Sook JLW, Ismail SF, Boon OP, Cheng PS

Objectives: Sarcopenia has emerged as a significant aging-related disease that affects many facets of societal-level and patient-level public health. This study analysed knowledge of sarcopenia and associated socio-demographic factors among...
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Cortical Thickness and Brain Glucose Metabolism in Healthy Aging

Baik K, Jeon S, Yang SJ, Na Y, Chung SJ, Yoo HS, Yun M, Lee PH, Sohn YH, Ye BS

Background and Purpose We aimed to determine the effect of demographic factors on cortical thickness and brain glucose metabolism in healthy aging subjects. Methods The following tests were performed on 71 subjects with...
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Hypoperfusion Precedes Tau Deposition in the Entorhinal Cortex: A Retrospective Evaluation of ADNI-2 Data

Kapadia A, Billimoria K, Desai P, Grist JT, Heyn C, Maralani P, Symons S, Zaccagna F

Background and Purpose Tau deposition in the entorhinal cortex is the earliest pathological feature of Alzheimer’s disease (AD). However, this feature has also been observed in cognitively normal (CN) individuals and...
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Interventions on Well-being, Occupational Health, and Aging of Healthcare Workers: A Scoping Review of Systematic Reviews

Fadel M, Roquelaure Y, Descatha A

Introduction With recent higher awareness of the necessity of improving healthcare workers’ well-being, we aimed to overview systematic reviews dealing with interventions on well-being, occupational health, and aging of healthcare workers. Methods From...
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Impact of Body Mass Index on Survival Depending on Sex in 14,688 Patients with Gastric Cancer in a Tertiary Hospital in South Korea

Jo HH, Kim N, Jang J, Choi Y, Park J, Park YM, Ahn S, Yoon H, Shin CM, Park YS, Lee DH, Oh HJ, Lee HS, Park YS, Ahn SH, Suh YS, Park DJ, Kim HH, Kim JW, Kim JW, Lee KW, Chang W, Park JH, Lee YJ, Lee KH, Kim YH

Background/Aims: The incidence and prognosis of gastric cancer (GC) shows sex difference. This study aimed to evaluate the effect of body mass index (BMI) on GC survival depending on sex. Methods: The...
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Molecular and Cellular Crosstalk between Bone and Brain: Accessing Bidirectional Neural and Musculoskeletal Signaling during Aging and Disease

Schurman CA, Burton JB, Rose J, Ellerby LM, Alliston T, Schilling B

Molecular omics technologies, including proteomics, have enabled the elucidation of key signaling pathways that mediate bidirectional communication between the brain and bone tissues. Here we provide a brief summary of...
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Correction of Involutional Entropion by Excising Redundant Skin and Pretarsal Orbicularis Muscle without Vertical and Horizontal Tarsal Fixation

Choi EW, Jang SY

Purpose: This study evaluated the effect of the excision of redundant skin and pretarsal orbicularis muscle, without vertical or horizontal tarsal fixation, on the correction of involutional entropion. Methods: This retrospective...
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A Randomized, Prospective, Split-Face Pilot Study to Evaluate the Safety and Efficacy of 532-nm and 1,064-nm Picosecond-Domain Neodymium:Yttrium-Aluminum-Garnet Lasers Using a Diffractive Optical Element for Non-Ablative Skin Rejuvenation: Clinical and Histological Evaluation

Han HS, Hong JK, Park SJ, Park BC, Park KY

Background: The advent of fractionated picosecond (ps) lasers has provided an opportunity to explore new ways of creating microinjuries in the skin to induce skin rejuvenation. Objective: To compare the efficacy...
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Age-dependent expression of ion channel genes in rat

Jung SC, Zhou T, Ko EA

Ion channels regulate a large number of cellular functions and their functional role in many diseases makes them potential therapeutic targets. Given their diverse distribution across multiple organs, the roles...
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Minoxidil Regulates Aging-Like Phenotypes in Rat Cortical Astrocytes In Vitro

Bang M, Yang SJ, Ahn T, Han SH, Shin CY, Kwon KJ

Mainly due to the slanted focus on the mechanism and regulation of neuronal aging, research on astrocyte aging and its modulation during brain aging is scarce. In this study, we...
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Current Updates and Unmet Needs of Brain MRI-Based Artificial Intelligence Software for Patients With Neurodegenerative Diseases in the Republic of Korea

Jeong SY, Suh CH, Heo H, Shim WH, Kim SJ

In aging societies, incidences of neurodegenerative diseases such as Alzheimer’s disease and Parkinson’s disease are increasing. Neurodegenerative diseases are bringing main challenges to the healthcare system in today’s world. Analyzing...
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