Arch Craniofac Surg.  2019 Aug;20(4):260-264. 10.7181/acfs.2019.00283.

A case of malignant melanoma after repeated recurrent dysplastic nevi

  • 1Department of Plastic and Reconstructive Surgery, Pusan National University School of Medicine, Busan, Korea.
  • 2Biomedical Research Institute, Pusan National University Hospital, Busan, Korea.
  • 3Department of Pathology, Pusan National University School of Medicine, Busan, Korea.
  • 4Department of Dermatology, Pusan National University School of Medicine, Busan, Korea.
  • 5Department of Internal Medicine, Pusan National University School of Medicine, Busan, Korea.


Dysplastic nevus is common and affects about 10% of the northern European-descendent population. Studies over the past several decades have identified dysplastic nevi as a risk factor for malignant melanoma. Furthermore, in rare cases, they confirmed that dysplastic nevi have progressed to melanoma. Cases in which dysplastic nevi progressed to malignant melanoma in multiple studies are not uncommon. A 35-year-old woman presented with the major symptom of multiple itchy brown nodules (2.0 cm× 1.3 cm) in the left cheek that had first appeared 20 years earlier. Complete excision was performed at the first visit; subsequent biopsy confirmed that they were dysplastic nevi. They recurred three times over 3 years at the same site, all of which were histologically diagnosed as dysplastic nevi. Five years after the final excision, a brownish nodule developed in the left cheek, with others at the left temporal region, right retroauricular region, and left shoulder at the same time. These lesions were histologically diagnosed as malignant melanoma. We experienced a case of malignant melanoma that occurred at the same site after three recurrences of dysplastic nevi. Although rare, the possibility of malignant melanoma should be considered in follow-ups in cases involving repeatedly recurrent dysplastic nevi.


Dysplastic nevus syndrome; Melanoma; Recurrence

MeSH Terms

Dysplastic Nevus Syndrome*
Follow-Up Studies
Risk Factors
Temporal Lobe
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