Nat Prod Sci.  2019 Jun;25(2):115-121. 10.20307/nps.2019.25.2.115.

Chemical Constituents from Solenostemma argel and their Cholinesterase Inhibitory Activity

Affiliations
  • 1Laboratoire de Biochimie Appliquée, Département des Sciences de la Nature et de la Vie, Université Frères Mentouri-Constantine 1; 25000 Constantine, Algeria. rym.demmak@umc.edu.dz
  • 2Laboratoire de Pharmacognosie, Univ. Lille, EA 7394 – ICV – Institut Charles Viollette; F-59000 Lille, France.
  • 3Laboratoire d'Obtention des Substances Thérapeutiques (LOST), Campus Chaabet-Ersas, Département de chimie, Université des Frères Mentouri-Constantine; 25000 Constantine, Algeria.

Abstract

Alzheimer's disease is a chronic neurodegenerative disorder with no curative treatment. The commercially available drugs, which target acetylcholinesterase, are not satisfactory. The aim of this study was to investigate the cholinesterase inhibitory activity of Solenostemma argel aerial part. Eight compounds were isolated and identified by NMR: kaempferol-3-O-glucopyranoside (1), kaempferol (2), kaempferol-3-glucopyranosyl(1→6)rhamnopyranose (3) p-hydroxybenzoic acid (4), dehydrovomifoliol (5), 14,15-dihydroxypregn-4-ene-3,20-dione (6), 14,15-dihydroxy-pregn-4-ene-3,20-dione-15β-D-glucopyranoside (7) and solargin I (8). Two of them (compounds 2 and 3) could inhibit over 50 % of butyrylcholinesterase activity at 100 µM. Compound (2) displayed the highest inhibitory effect against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) with a slight selectivity towards the latter. Molecular docking studies supported the in vitro results and revealed that (2) had made several hydrogen and Ï€-Ï€ stacking interactions which could explain the compound potency to inhibit AChE and BChE.

Keyword

Alzheimer's disease; Cholinesterase; Molecular docking; Solenostemma argel

MeSH Terms

Acetylcholinesterase
Alzheimer Disease
Butyrylcholinesterase
Cholinesterases*
Hydrogen
In Vitro Techniques
Neurodegenerative Diseases
Acetylcholinesterase
Butyrylcholinesterase
Cholinesterases
Hydrogen
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